Bloody Minded
Bloody Minded Crew
Baffled by blood? Confused by coags? Traumatised by TTP? Planning on quitting medical school because you've just finished haem block? Join the registrars of the Bloody Minded Crew as they tour the world of haematology one topic at at a time while procrastinating from their day jobs.
Your time is precious, so to maximise your return we look at each topic at a variety of levels so you can tailor your learning. Check out more at www.bloodyminded.com.au
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Top 10 Bloody Minded Episodes
Goodpods has curated a list of the 10 best Bloody Minded episodes, ranked by the number of listens and likes each episode have garnered from our listeners. If you are listening to Bloody Minded for the first time, there's no better place to start than with one of these standout episodes. If you are a fan of the show, vote for your favorite Bloody Minded episode by adding your comments to the episode page.
07/09/24 • 36 min
Echis carinatus, Daboia russelii, Uxyuranus scullatellas. Never has so much been owed by so many humans to so few... snakes. For the first time the Bloody Minded Crew is delighted to welcome guests! Join consultant haematologist Dr Maeve Crowley and senior hospital scientist Kent Chapman for a tour of the wonderful world of exotic clotting times.
This episode was so big we had to split it in two! In this first half of the episode we interview Kent Chapman, senior hospital scientist in haemostasis at John Hunter Hospital in Newcastle regarding the variety of snake venom testing available in the lab.
Kent has over 20 years of experience in laboratory haemostasis and coagulation with a special interest in von Willbrand factor, ADAMTS13 testing and complement interactions with the coagulation cascade
Timestamps:
00:59 - Interview Overview
03:46 - Introductions
08:12 - What's in the snake drawer?
10:39 - Dilute Russell Viper Venom Time
15:05 - DOAC interference
19:20 - Echis Time
24:02 - Taipan Time
26:14 - Pathological Envenomation
33:15 - Sandflies?!
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
06/11/24 • 36 min
To infinXa and beyond! Let go of your veXation and eXalt our eXacting approach to coagulation testing. You'll know eXactly what you need for your eXams as long as they ask you about anti-Xa testing, thrombin times, fibrinogen and absolutely nothing else.
Timestamps
0:00 - Introductions
2:40 - Thombin Time - Lab
5:45 - Thrombin Time - Clinical
9:24 - Thrombin Time - Variants
11:06 - Anti-Xa Intro
14:53 - Anti-Xa - Lab
19:04 - Anti-Xa - Clinical
25:21 - Santa-Clauss (Fibrinogen)
30:20 - Cases
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
05/28/24 • 47 min
“Have you not done tormenting me with your accursed time?“ Senior scientists Vladimir and Estragon are waiting quite a while for a clot to form in their tube. How should you react to prolonged clotting times? We cover an approach to prolonged PT and aPTT, as well as discuss the mechanism of common anticoagulants and their impact on these basic tests.
Timestamps
00:00 - Intro
01:22 - Episode 2 Recap
03:13 - Why clotting times prolong
05:38 - Short clotting times
07:00 - Platelets and clotting times
08:00 - Introduction to Anticoagulants
10:25 - Unfractionated Heparin
17:04 - Low Molecular Weight Heparins
20:20 - Fondaparinux
21:37 - Vitamin K "Inhibitors"
27:55 - Direct Oral Anticoagulants
33:04 - Anticoagulants Recap
34:10 - An approach to long clotting times
35:58 - Cases
45:45 - Takehomes
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
08/20/24 • 30 min
“It’s Test. Coombs Test. And I like my erythrocytes shaken, not stirred.” Return the lab (where some of the Bloody Minded Crew truly belong) and uncover the secrets of the most important test in haemolysis - the Direct Antiglobulin Test. Learn to whisper its secrets and it can guide you to identifying the true culprit behind these broken red cells.
Timestamps:
0:57 - Coombs Noir
2:05 - Naming History
4:32 - DAT in the Lab
11:52 - Doing a DAT - Exam Version
14:35 - Eluates (Briefly)
15:45 - False Positives & Negatives
18:24 - When to DAT?
21:55 - Distilling the DAT - Interpretation
25:38 - DAT-Vanced Topics
29:24 - Takehome Points
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
09/17/24 • 36 min
MAHA TMA Gandhi once said a cell for a cell makes the whole body anaemic, or something along those lines. There’s so much more to DAT negative haemolysis than just DIC. Get out those buckets and put your sorting hats on - it’s time to go where detective Coombs never dared to and look over the DAT negative haemolytic processes.
Timestamps
2:42 - Approach to DAT negatives - main categories
4:53 - Intrinsic Bucket 1: Membrane disorders
16:16 - Intrinsic Bucket 2: Enzyme disorders
18:51 - Intrinsic Bucket 3: Haemoglobin disorders
24:05 - Extrinsic Bucket 1: Microangiopathies
26:54 - Extrinsic Bucket 2: Infections
28:07 - Extrinsic Bucket 3: "Macroangiopathies"
30:58 - Extrinsic Bucket 4: Liver stuff
34:07 - Take home messages
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
Episode 22 - B is for B-Cell | Immunology 101
Bloody Minded
11/05/24 • 35 min
A is for Antibody. B is for B-cell. C is for Cryoglobul... wait no we’ve covered that already. If you struggle to tell your thymus from an isthmus, can’t see the humour in humoural immunity and think a bursa is just some fancy elbow cushion then THIS is the episode for you. Join the Bloody Minded Crew as they dust off their undergraduate immunology degrees, get back to the classroom and cover the foundations of the immune system in preparation for tackling our upcoming malignant diseases.
Timestamps
3:43 - The Immune System
4:50 - The Spleen
5:36 - The Thymus
6:19 - The Lymph Nodes
8:19 - The Innate Immune System
13:16 - The Adaptive Immune System
16:56 - VDJ recombination
21:21 - MHC/HLA
24:54 - Antibodies!
27:42 - Class switching
28:58 - The purpose of Plasma Cells
30:33 - An immune response - start to finish
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
Episode 23 - Help I found a paraprotein | MGUS + The Spectrum of Plasma Cell Dyscrasias
Bloody Minded
11/12/24 • 31 min
Ordered something you shouldn’t have and accidentally found a paraprotein again? Shame on you, but now you have to do something with it. Maybe you were genuinely suspicious for myeloma. If incidentally discovered lab findings are leaving you smouldering, this is the episode for you!
Join Nick, Cale and Bashar as they chat about the spectrum of plasma cell dyscrasias, and cover the precursor conditions MGUS and Smouldering Myeloma.
Timestamps
2:53 - What is a paraprotein?
5:56 - The heavy chain component
9:40 - The spectrum of plasma cell disorders
10:12 - MGUS
11:33 - How common is MGUS?
15:24 - You've found a paraprotein - what next?
17:38 - IMWG MGUS Criteria
19:47 - Mayo Score for Risk Stratification
22:25 - Serum free light chain ratio
24:25 - Bence Jones proteins
26:21 - Smouldering myeloma
27:30 - IMWG Smouldering myeloma criteria
29:16 - Risk of progression to MM
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
11/26/24 • 47 min
RVd, KTd, CyBorD, DVd, EloRd - Looks like the cat got on the keyboard. Oh wait, this is just the myeloma regimens in day therapy today.
Come on a journey as we attempt (mostly successfully) to avoid drug trade names! Let go of your proteasome inhibitions, phenotype your red cells and let us modulate your understanding of what it is to treat myeloma with an alphabet soups worth of drugs. We sincerely apologise to our endocrinology colleagues for how much dexamethasone we use in this episode but also generally.
Timestamps
4:00 - Overview of the treatment journey
9:49 - Steroids - not the bulking kind
13:54 - Immunomodulators - the IMiDs
19:46 - Proteasome inhibitors - Bortezomib, Carflizomib
24:45 - Monoclonal antibodies - Daratumumab, Elotuzumab
28:31 - SINE Inhibitor - Selinexor
29:27 - Antibody-drug conjugates - Belantamab mafodotin
30:27 - CELMoDs - Iberdomide, mezigdomide
31:06 - Standard chemotherapy
33:15 - Autologous stem cell transplant
38:21 - T-cell directed therapy - BiTes, CAR-T
40:57 - Supportive care
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
12/03/24 • 35 min
MGUS and Myeloma too simple for your tastes? Do you like vague presentations and biopsying many tissues in a sometimes wild goose chase? Why does Congo have all the birefringent apples? Go 'AAaah' as we TTRy to unpack ALl the problems that come with that most protean of disease - Systemic Amyloidosis!
Timestamps
3:04 - Pathophysiology of Amyloid
6:52 - All The Subtypes of Amyloid
7:56 - AA Amyloid
10:08 - ABeta2M Amyloid
11:04 - Age-Related Amyloidosis = wtATTR = WTTA = SSA
14:38 - AL Amyloidosis
16:24 - Diagnosis of Amyloid
22:25 - Clinical Presentation of Amyloid
27:10 - Prognosis
32:17 - Take Home Messages
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
07/16/24 • 35 min
Echis carinatus, Daboia russelii, Uxyuranus scullatellas. Never has so much been owed by so many humans to so few... snakes. In this split episode, For the first time the Bloody Minded Crew is delighted to welcome guests! Join our coagulation experts Dr Maeve Crowley and Kent Chapman for a tour of the wonderful world of exotic clotting times.
This episode was so big we split it in half! In Part 2 of this episode we step out of the lab and chat with consultant haematologist Dr Maeve Crowley about the clinical uses of snake based testing and the subtleties of lupus anticoagulant testing.
Timestamps
1:43 - Introductions
05:07 - The DRVVT
06:57 - LA Testing in Practice
09:00 - Mixing Studies
13:33 - Testing and Anticoagulation
19:27 - Significant LAs
21:20 - RAPS, TRAPS and Decision Making in LA
27:20 - Taipan and Echis Times
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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FAQ
How many episodes does Bloody Minded have?
Bloody Minded currently has 47 episodes available.
What topics does Bloody Minded cover?
The podcast is about Life Sciences, Med School, Medicine, Podcasts, Education, Science and Foam.
What is the most popular episode on Bloody Minded?
The episode title 'Episode 11 - What is Blood ft. Erythrocytes | Haematopoiesis & Haematinics Overview' is the most popular.
What is the average episode length on Bloody Minded?
The average episode length on Bloody Minded is 38 minutes.
How often are episodes of Bloody Minded released?
Episodes of Bloody Minded are typically released every 7 days.
When was the first episode of Bloody Minded?
The first episode of Bloody Minded was released on May 14, 2024.
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