Episode 25 - Alphabet Soup | Overview of Myeloma Treatments

11/26/24 • 47 min

RVd, KTd, CyBorD, DVd, EloRd - Looks like the cat got on the keyboard. Oh wait, this is just the myeloma regimens in day therapy today.
Come on a journey as we attempt (mostly successfully) to avoid drug trade names! Let go of your proteasome inhibitions, phenotype your red cells and let us modulate your understanding of what it is to treat myeloma with an alphabet soups worth of drugs. We sincerely apologise to our endocrinology colleagues for how much dexamethasone we use in this episode but also generally.
Timestamps
4:00 - Overview of the treatment journey
9:49 - Steroids - not the bulking kind
13:54 - Immunomodulators - the IMiDs
19:46 - Proteasome inhibitors - Bortezomib, Carflizomib
24:45 - Monoclonal antibodies - Daratumumab, Elotuzumab
28:31 - SINE Inhibitor - Selinexor
29:27 - Antibody-drug conjugates - Belantamab mafodotin
30:27 - CELMoDs - Iberdomide, mezigdomide
31:06 - Standard chemotherapy
33:15 - Autologous stem cell transplant
38:21 - T-cell directed therapy - BiTes, CAR-T
40:57 - Supportive care

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Previous Episode

Episode 24 - Blue Fried Eggs | Intro to Multiple Myeloma

==
I do not like blue eggs and ham,
I do not like them, Sam I Am.
They crowd and clump, they grow too fast,
Causing troubles that can last.
They make my bones feel weak and sore,
And through my kidneys they gnaw!
I do not like blue eggs, you see,
They're signs of something wrong with me.
==
Timestamps
3:35 - Recap of MGUS + smouldering myeloma
4:42 - Clinical case - Mr. Peter Rotein
8:15 - What is rouleaux?
10:30 - Bone marrow biopsies - what, how, how much ow?
15:29 - Multiple myeloma
16:41 - CRAB Criteria
18:26 - SLiM Criteria
19:24 - Clinical presentations of myeloma
21:48 - Plasmacytomas
22:56 - Causes of myeloma?
24:45 - Prognosis

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Next Episode

Episode 26 - Trip to the Congo | Amyloidosis Overview

MGUS and Myeloma too simple for your tastes? Do you like vague presentations and biopsying many tissues in a sometimes wild goose chase? Why does Congo have all the birefringent apples? Go 'AAaah' as we TTRy to unpack ALl the problems that come with that most protean of disease - Systemic Amyloidosis!
Timestamps
3:04 - Pathophysiology of Amyloid
6:52 - All The Subtypes of Amyloid
7:56 - AA Amyloid
10:08 - ABeta2M Amyloid
11:04 - Age-Related Amyloidosis = wtATTR = WTTA = SSA
14:38 - AL Amyloidosis
16:24 - Diagnosis of Amyloid
22:25 - Clinical Presentation of Amyloid
27:10 - Prognosis
32:17 - Take Home Messages