Episode 9 - Snakes on the (Laboratory) Brain | Venoms in the Coagulation Lab
07/09/24 • 36 min
Echis carinatus, Daboia russelii, Uxyuranus scullatellas. Never has so much been owed by so many humans to so few... snakes. For the first time the Bloody Minded Crew is delighted to welcome guests! Join consultant haematologist Dr Maeve Crowley and senior hospital scientist Kent Chapman for a tour of the wonderful world of exotic clotting times.
This episode was so big we had to split it in two! In this first half of the episode we interview Kent Chapman, senior hospital scientist in haemostasis at John Hunter Hospital in Newcastle regarding the variety of snake venom testing available in the lab.
Kent has over 20 years of experience in laboratory haemostasis and coagulation with a special interest in von Willbrand factor, ADAMTS13 testing and complement interactions with the coagulation cascade
Timestamps:
00:59 - Interview Overview
03:46 - Introductions
08:12 - What's in the snake drawer?
10:39 - Dilute Russell Viper Venom Time
15:05 - DOAC interference
19:20 - Echis Time
24:02 - Taipan Time
26:14 - Pathological Envenomation
33:15 - Sandflies?!
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
Echis carinatus, Daboia russelii, Uxyuranus scullatellas. Never has so much been owed by so many humans to so few... snakes. For the first time the Bloody Minded Crew is delighted to welcome guests! Join consultant haematologist Dr Maeve Crowley and senior hospital scientist Kent Chapman for a tour of the wonderful world of exotic clotting times.
This episode was so big we had to split it in two! In this first half of the episode we interview Kent Chapman, senior hospital scientist in haemostasis at John Hunter Hospital in Newcastle regarding the variety of snake venom testing available in the lab.
Kent has over 20 years of experience in laboratory haemostasis and coagulation with a special interest in von Willbrand factor, ADAMTS13 testing and complement interactions with the coagulation cascade
Timestamps:
00:59 - Interview Overview
03:46 - Introductions
08:12 - What's in the snake drawer?
10:39 - Dilute Russell Viper Venom Time
15:05 - DOAC interference
19:20 - Echis Time
24:02 - Taipan Time
26:14 - Pathological Envenomation
33:15 - Sandflies?!
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
Previous Episode
Episode 8 - In the Lab: The Bethesda Assay
The Bethesda Assay has been tormenting haematology trainees since well before Fallout or Skyrim. Uncover its secrets in this episode and you'll be sorting acquired haemophilia faster than you can say Fus Ro Dah
Timestamps:
01:50 - Bethesda Assay Intro
05:17 - How it works (and Bethesda Units)
10:25 - Nijmegen modification & dealing with Emicizumab
13:48 - Bethesda Assay summary for Exams
18:55 - Clinical Relevance
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
Next Episode
Episode 10 - Snakes on the (Clinical) Brain | Venoms in Clinical Use with Dr Maeve Crowley
Echis carinatus, Daboia russelii, Uxyuranus scullatellas. Never has so much been owed by so many humans to so few... snakes. In this split episode, For the first time the Bloody Minded Crew is delighted to welcome guests! Join our coagulation experts Dr Maeve Crowley and Kent Chapman for a tour of the wonderful world of exotic clotting times.
This episode was so big we split it in half! In Part 2 of this episode we step out of the lab and chat with consultant haematologist Dr Maeve Crowley about the clinical uses of snake based testing and the subtleties of lupus anticoagulant testing.
Timestamps
1:43 - Introductions
05:07 - The DRVVT
06:57 - LA Testing in Practice
09:00 - Mixing Studies
13:33 - Testing and Anticoagulation
19:27 - Significant LAs
21:20 - RAPS, TRAPS and Decision Making in LA
27:20 - Taipan and Echis Times
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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