Cannabis and Tolerance Refresh!

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04/05/23 • 30 min

Cannabis and Tolerance Refresh!

THANK you for your support! We love when you guys reach out. We do this for one reason only, that’s for YOU! Please rate, subscribe, tell us what you like, THANK YOU for coming back!

I love this topic, as usual, this is one that’s near-and-dear to me, and is why I like to share with you all.

Are you feeling sometimes that you’re not getting the same “umph” from your cannabis? Are you getting frustrated? We’ll not for long!

We’ll provide tips in this episode to assist with that and any of these pesky tolerance issues moving forward!

Why is this topic important?

Developing a tolerance can affect your overall experience with cannabis and potentially lead to increased use and dependence.

For me, I think it’s the risk of looking elsewhere for your medicine...for something “stronger@ when you don’t need that...especially when you can just take a day or two, reset, and get efficacy from your cannabis again.

So tune in as we talk about tolerance, what it is, why it happens, and how you can keep your cannabis Always feeling good!

References:

"Cannabis Tolerance: What It Is and How to Manage It" by Leafly (2019) - https://www.leafly.com/learn/cannabis-tolerance
"Cannabis Tolerance: Everything You Need to Know" by Verywell Mind (2021) -https://www.leafly.com/learn/cannabis-tolerance
"Marijuana Tolerance: A Comprehensive Review of the Phenomenon" by Gorelick et al. (2012) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570572/

The Science of Tolerance:

"The Endocannabinoid System and Cannabinoid Receptors in the Brain: Signaling Through CB1 and CB2 Receptors" by Howlett et al. (2010) - https://pubmed.ncbi.nlm.nih.gov/20590555/
"Toward a Comprehensive Understanding of Cannabinoid Tolerance and Dependence" by Lichtman and Martin (2005) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562334/
"Effect of Oral THC and Smoked Cannabis on Subjective and Physiological Effects" by Hunault et al. (2014) - https://pubmed.ncbi.nlm.nih.gov/24160757/
"CB1 Cannabinoid Receptor-Mediated Signaling: A Key Target for Interventions in CNS Diseases" by Howlett et al. (2002) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366186/
"Differential Effects of Cannabis Strains and Dabbing on Tolerance and Cannabinoid Receptor Expression in Adolescent Mice" by Renard et al. (2017) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379124/
"Cannabis, Cannabinoids, and Sleep: a Review of the Literature" by Babson et al. (2017) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312634
"Cannabis and Cannabinoids in Pain Management: An Overview" by Whiting et al. (2015) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569620/
"Cannabidiol Attenuates Tolerance to Delta-9-Tetrahydrocannabinol and Reverses Chemically Induced Amygdala Fear Responses" by Pamplona et al. (2018) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877694/
"Cannabidiol Interferes with the Effects of Delta-9-Tetrahydrocannabinol in Human Saliva" by Hartman et al. (2015) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714465/
"Pharmacokinetics of Cannabidiol in Dogs" by Samara et al. (2020) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318252/

Info:

Cannabis Connoisseur Podcast Info:

E-mail us at: [email protected]

Youtube: https://www.youtube.com/watch?v=7BRwpUrBg...

Cannabis and Tolerance Refresh!

THANK you for your support! We love when you guys reach out. We do this for one reason only, that’s for YOU! Please rate, subscribe, tell us what you like, THANK YOU for coming back!

I love this topic, as usual, this is one that’s near-and-dear to me, and is why I like to share with you all.

Are you feeling sometimes that you’re not getting the same “umph” from your cannabis? Are you getting frustrated? We’ll not for long!

We’ll provide tips in this episode to assist with that and any of these pesky tolerance issues moving forward!

Why is this topic important?

Developing a tolerance can affect your overall experience with cannabis and potentially lead to increased use and dependence.

So tune in as we talk about tolerance, what it is, why it happens, and how you can keep your cannabis Always feeling good!

References:

"Cannabis Tolerance: What It Is and How to Manage It" by Leafly (2019) - https://www.leafly.com/learn/cannabis-tolerance
"Cannabis Tolerance: Everything You Need to Know" by Verywell Mind (2021) -https://www.leafly.com/learn/cannabis-tolerance
"Marijuana Tolerance: A Comprehensive Review of the Phenomenon" by Gorelick et al. (2012) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570572/

The Science of Tolerance:

"The Endocannabinoid System and Cannabinoid Receptors in the Brain: Signaling Through CB1 and CB2 Receptors" by Howlett et al. (2010) - https://pubmed.ncbi.nlm.nih.gov/20590555/
"Toward a Comprehensive Understanding of Cannabinoid Tolerance and Dependence" by Lichtman and Martin (2005) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562334/
"Effect of Oral THC and Smoked Cannabis on Subjective and Physiological Effects" by Hunault et al. (2014) - https://pubmed.ncbi.nlm.nih.gov/24160757/
"CB1 Cannabinoid Receptor-Mediated Signaling: A Key Target for Interventions in CNS Diseases" by Howlett et al. (2002) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366186/
"Differential Effects of Cannabis Strains and Dabbing on Tolerance and Cannabinoid Receptor Expression in Adolescent Mice" by Renard et al. (2017) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5379124/
"Cannabis, Cannabinoids, and Sleep: a Review of the Literature" by Babson et al. (2017) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312634
"Cannabis and Cannabinoids in Pain Management: An Overview" by Whiting et al. (2015) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569620/
"Cannabidiol Attenuates Tolerance to Delta-9-Tetrahydrocannabinol and Reverses Chemically Induced Amygdala Fear Responses" by Pamplona et al. (2018) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877694/
"Cannabidiol Interferes with the Effects of Delta-9-Tetrahydrocannabinol in Human Saliva" by Hartman et al. (2015) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714465/
"Pharmacokinetics of Cannabidiol in Dogs" by Samara et al. (2020) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318252/

Info:

Cannabis Connoisseur Podcast Info:

E-mail us at: [email protected]

Youtube: https://www.youtube.com/watch?v=7BRwpUrBg...

Previous Episode

Cannabis and Jet Lag: 10 Ways Cannabis Can Assist!

Welcome back! We have a familiar episode for you all! Not too heavy, and maybe a bit of fun as well!

Jack and I have been traveling recently, it’s spring break season, so we’re going to talk about that pesky ailment you may get when you’re zipping around the world in and out of different times zones...

To begin, let’s ask the big question: What is Jet Lag and How Does It Occur?

Answer? Jet lag is a temporary sleep disorder that occurs when a person travels across multiple time zones, causing a disruption in their internal clock, or circadian rhythm.

Circadian Rhythm- The circadian rhythm is a 24-hour internal clock that regulates various physiological processes, including the sleep-wake cycle.

When a person travels through different time zones, the body's internal clock becomes misaligned with the destination's local time, resulting in a range of symptoms.

This disruption in the circadian rhythm can lead to symptoms such as insomnia, fatigue, irritability, difficulty concentrating, and gastrointestinal issues.

Info:

Cannabis Connoisseur Podcast Info:

E-mail us at: [email protected]

Youtube: https://www.youtube.com/watch?v=7BRwpUrBgQM&t=5s

References:

Sleep regulation: Journal of Clinical Sleep Medicine - "Effectiveness of Cannabinoids for Treatment of Sleep Disorders - A Systematic Review and Meta-Analysis of Controlled Studies" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326553/

Anxiety reduction: Journal of Psychopharmacology - "Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients" - https://pubmed.ncbi.nlm.nih.gov/21307846/

Pain relief: Cannabis and Cannabinoid Research - "Cannabis and Pain: A Clinical Review" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849726/

Appetite stimulation: Current Opinion in Clinical Nutrition and Metabolic Care - "Cannabinoids in the Treatment of Cancer Cachexia and Anorexia: A Systematic Review and Meta-Analysis" - https://journals.lww.com/co-clinicalnutrition/Abstract/2016/11000/Cannabinoids_in_the_treatment_of_cancer_cachexia.7.aspx

Anti-inflammatory effects: European Journal of Pain - "Cannabis-based medicines for chronic neuropathic pain in adults" - https://pubmed.ncbi.nlm.nih.gov/29134767/

Improved mood: Journal of Affective Disorders - "Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors" - https://pubmed.ncbi.nlm.nih.gov/29885468/

Relaxation: Current Psychiatry Reports - "Potential Benefits of CBD Oil: A Review of the Emerging Evidence" - https://pubmed.ncbi.nlm.nih.gov/29633088/

Increased focus: Journal of Psychopharmacology - "Cannabis, a complex plant: different compounds and different effects on individuals" - https://journals.sagepub.com/doi/10.1177/0269881113491531

Gastrointestinal relief: Cannabis and Cannabinoid Research - "Cannabinoids for treating inflammatory bowel diseases: where are we and where do we go?" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844026/

Neuroprotection: Neural Regeneration Research - "Cannabidiol: A Promising Drug for Neurodegenerative Disorders?" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938896/

Adjust your sleep schedule before your trip: Harvard Health Publishing - "How to minimize jet lag" - https://www.health.harvard.edu/staying-healthy/how-to-minimize-jet-lag

Stay hydrated: Mayo Clinic - "Jet lag disorder" - https://www.mayoclinic.org/diseases-conditions/jet-lag/symptoms-causes/syc-20374027

Get natural light: American Academy of Sleep Medicine - "Jet lag: Strategies for minimizing its effects" - https://aasm.org/resources/factsheets/jetlag.pdf

Take naps: National Sleep Foundation - "How to Beat Jet Lag: Tips for Successful Time Zone Adjustment" - https://www.sleepfoundation.org/articles/how-beat-jet-lag-tips-successful-time-zone-adjustment

Avoid alcohol and caffeine: National Sleep Foundation - "How to Beat Jet Lag: Tips for Successful Time Zone Adjustment" - https://www.sleepfoundation.org/articles/how-beat-jet-lag-tips-successful-time-zone-adjustment

Exercise: Harvard Health Publishing - "How to minimize jet lag" - https://www.health.harvard.edu/staying-healthy/how-to-minimize-jet-lag

Use sleep aids wisely: Mayo Clinic - "Jet lag disorder" - https://www.mayoclinic.org/diseases-conditions/jet-lag/diagnosis-treatment/drc-20374032

Be patient: American Academy of Sleep Medicine - "Jet lag: Strategies for minimizing its effects" - https://aasm.org/resources/factsheets/jetlag.pdf

Next Episode

Cannabis and Seasonal Allergies in 2023: Top 4 ways cannabis can assist!

Cannabis and Seasonal Allergies in 2023- 4 Ways Cannabis Can Assist!

Why is this topic important?

I’ve compiled a few thoughts on this, including:

Seasonal allergies affect a large portion of the population and can have a negative impact on quality of life.

Traditional treatments for seasonal allergies may not work for everyone or may come with unwanted side effects.

Cannabis offers a potential alternative or complementary treatment option for seasonal allergies.

Cannabis may have anti-inflammatory and antihistamine properties, pain relief, etc, which can help alleviate some of the symptoms associated with allergies.

Research on the potential benefits and risks of cannabis for seasonal allergies can help inform healthcare professionals and patients in making informed decisions about treatment options....let your doctors know!!

References:

Hammell DC, Zhang LP, Ma F, Abshire SM, McIlwrath SL, Stinchcomb AL, Westlund KN. Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. European Journal of Pain. 2016;20(6):936-948. doi:10.1002/ejp.818

Ribeiro A, Almeida VI, Costola-de-Souza C, et al. Cannabidiol improves lung function and inflammation in mice submitted to LPS-induced acute lung injury. Immunopharmacol Immunotoxicol. 2015;37(1):35-41. doi:10.3109/08923973.2014.976794

Costa MA, Fonseca BM, Keating JE, et al. Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of the G-protein-coupled receptor for leukotriene B4. J Immunol. 1999;163(2):979-988. PMID: 10395701

ElSohly MA, Radwan MM, Gul W, Chandra S, Galal A. Phytochemistry of Cannabis sativa L. In: Pertwee RG, ed. Handbook of Cannabis. Oxford University Press; 2014:3-22.

Malfait AM, Gallily R, Sumariwalla PF, et al. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci U S A. 2000;97(17):9561-9566. doi:10.1073/pnas.160105897

Rog DJ, Nurmikko TJ, Friede T, Young CA. Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis. Neurology. 2005;65(6):812-819. doi:10.1212/01.wnl.0000176753.45410.8b

D’Souza DC, Perry E, MacDougall L, et al. The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for psychosis. Neuropsychopharmacology. 2004;29(8):1558-1572. doi:10.1038/sj.npp.1300496

Gertsch J, Leonti M, Raduner S, et al. Beta-caryophyllene is a dietary cannabinoid. Proc Natl Acad Sci U S A. 2008;105(26):9099-9104. doi:10.1073/pnas.0803601105

Info:

Cannabis Connoisseur Podcast Info:

E-mail us at: [email protected]

Youtube: https://www.youtube.com/watch?v=7BRwpUrBgQM&t=5s

DISCLAIMER

***Please note that the information provided in this podcast is for educational and informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have heard in this podcast. The use of cannabis for medical purposes should be discussed with a healthcare professional and in compliance with local laws and regulations.***