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Ketogeek's Podcast - 49. The Bottom-Up Approach Towards Health & Nutrition | Gabor Erdosi

49. The Bottom-Up Approach Towards Health & Nutrition | Gabor Erdosi

Explicit content warning

10/04/18 • 84 min

Ketogeek's Podcast

While the mainstream news is focused primarily on a top-down approach towards food and health aimlessly tossing around observational studies, Gabor Erdosi and even us at Ketogeek are more focused on a bottom up approach starting from mechanistic ways in which food is metabolized and impacts the body as a whole.

Bio: Gabor Erdosi has a masters in molecular biology and is the brains behind the Facebook group "Lower Insulin". Nicknamed the "Adipose Jedi", Gabor has a unique approach of delving into complexity and understanding the inner workings of the human body.

Time Stamps:

7:32 – Background, weight loss & introduction into low carb

15:18 – Learning from thousands of scientific papers & moving beyond macro and micronutrients?

18:21 – Evolutionarily appropriate foods & finding recurring themes in successful diets

22:43 – Lowering Insulin Facebook group & focusing on high quality research

26:24 – Calorie-in Calorie-Out Model, Carbohydrate-Insulin Hypothesis and leveraging various models to troubleshoot health and address root causes

32:33 – Is it ketones or foods that promote ketosis that suppress appetite?

35:45 – How food processing can impact the body at a biochemical level

43:42 – Is Insulin Resistance a bad signaling problem?

51:10 – Feedback loops and how food processing can impact its metabolic response

55:49 – Why underfeeding and overfeeding studies may have impractical implications

58:37 – Thinking of fat gain as a protective mechanism

1:07:05 – “Compartmental Storage of Fat” and fat storage hierarchy in the body

1:012:13 – How is fat burning prioritized?

1:15:48 – Mechanistic role of intestinal barrier and gut permeability

1:20:08 – Why many conditions are acute processes going south

1:20:55 – Research you would like to see

1:22:28 – Final Plugs

Guest Links

Ketogeek Links:

Citations:

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While the mainstream news is focused primarily on a top-down approach towards food and health aimlessly tossing around observational studies, Gabor Erdosi and even us at Ketogeek are more focused on a bottom up approach starting from mechanistic ways in which food is metabolized and impacts the body as a whole.

Bio: Gabor Erdosi has a masters in molecular biology and is the brains behind the Facebook group "Lower Insulin". Nicknamed the "Adipose Jedi", Gabor has a unique approach of delving into complexity and understanding the inner workings of the human body.

Time Stamps:

7:32 – Background, weight loss & introduction into low carb

15:18 – Learning from thousands of scientific papers & moving beyond macro and micronutrients?

18:21 – Evolutionarily appropriate foods & finding recurring themes in successful diets

22:43 – Lowering Insulin Facebook group & focusing on high quality research

26:24 – Calorie-in Calorie-Out Model, Carbohydrate-Insulin Hypothesis and leveraging various models to troubleshoot health and address root causes

32:33 – Is it ketones or foods that promote ketosis that suppress appetite?

35:45 – How food processing can impact the body at a biochemical level

43:42 – Is Insulin Resistance a bad signaling problem?

51:10 – Feedback loops and how food processing can impact its metabolic response

55:49 – Why underfeeding and overfeeding studies may have impractical implications

58:37 – Thinking of fat gain as a protective mechanism

1:07:05 – “Compartmental Storage of Fat” and fat storage hierarchy in the body

1:012:13 – How is fat burning prioritized?

1:15:48 – Mechanistic role of intestinal barrier and gut permeability

1:20:08 – Why many conditions are acute processes going south

1:20:55 – Research you would like to see

1:22:28 – Final Plugs

Guest Links

Ketogeek Links:

Citations:

Previous Episode

undefined - 48. Finding Resources & Inspiration While Battling Cancer | Miriam Kalamian

48. Finding Resources & Inspiration While Battling Cancer | Miriam Kalamian

Miriam encountered cancer when her son was diagnosed in 2007 and now uses her experience and knowledge through this tough time to help others while providing inspiration and guidance to find what works for them individually in this battle.

Bio:

Miriam Kalamian is a nutrition educator, author, and consultant specializing in the ketogenic diet for cancer. In her work with hundreds of people, she has personally witnessed the life-changing effects of this powerful diet therapy, starting with her son's journey in 2007.

Time Stamps:

8:41 – Miriam’s story and her son’s encounter with brain tumor

11:09 – Her conversation with Dr. Thomas Seyfried & Ketogenic Diet

16:34 – Coming across Charlie Foundation

19:52 – Orchestrating cancer treatment and factors that could impact tumor growth

22:42 – Care oncology and repurposing drugs

25:13 – Press-Pulse strategy of cancer cell annihilation

28:20 – How do you prioritize and add healthy routines and intervention?

34:22 – Where do you find reliable resources for cancer and keto?

42:56 – Concerns with standard of care guidelines

50:31 – Modern companies that are using alternative methods towards health goals

54:31 – Protein Intake and challenges with veganism and Keto

1:07:16 – Why aren’t we getting a grip on cancer?

1:16:34 – Why do cancers return later?

1:21:22 – What kind of research do we need more for cancer?

1:22:24 – What potential technologies or research are coming out for cancer?

1:26:19 – Message for people who are fighting cancer

1:29:53 – Final Plugs

Guest Links

Ketogeek Links:

Next Episode

undefined - 50. The Controversy Behind Cholesterol, Processed Foods & a Bag of Wisdom | Nick Mailer

50. The Controversy Behind Cholesterol, Processed Foods & a Bag of Wisdom | Nick Mailer

Our long awaited special 50th episode where we delve into the bigger picture while discussing many topics including the biochemistry of cholesterol & statins, the scientific method, philosophy, processed foods and top it off with a dose of what we can learn from evolution and how to lead a fulfilling life. This one is a GREAT episode!

Bio:

After obtaining a degree from the University of Leeds in English and Philosophy, Nick Mailer co-authored the first book in the UK on the education possibilities of the Internet. He co-founded The Positive Internet Company, UK's premier open-source managed services organisation. He also founded the Campaign for Unmetered Telecommunications. He has spoken at conferences, including the Ancestral Health Symposium and Ketofest, on the nexus of culture, technology and semiotics. Since 2010, he has adopted a paleo-ish LCHF lifestyle, to which he nevertheless applies a multidisciplinary scepticism! He lives in London with his wife, daughter and cat.

Time Stamps:

0:15 - Epic Superhero Intro

9:13 - How did you get into Low Carb?

14:23 - A philosophical perspective, paradoxes and the impracticality of certain scientific models

18:40 - How different people handle paradoxes to their knowledge

20:55 - Will we get the next Galileo or Einstein in the world of science and research?

24:38 - Paradigm shifts in modern science and repeating human patterns when confronted with conflicting knowledge

29:26 - Meaning of a statement may be a method of of its verification

32:25 - What is a "Black Swan", Cholesterol and the narrative of the Kitavans

37:15 - PURE study and what knowledge you can obtain from observational studies

39:09 - Mevalonate pathway, statins and the importance of simplifying and understanding science

44:30 - The role of cholesterol, how statins disrupt the body's mechanisms and the impact of statins on a cellular level

47:51 - Why anyone can now obtain knowledge and should embrace complexity and details

52:00 - Concerns when people outsource critical thinking on social media forums and groups

55:42 - Pros and cons of deferring to an authority and how to ground yourself in a sea of too much information

1:06:05 - Difference between the pleasure of eating and the pain of eating

1:12:08 - Human adaptations, homeostatic mechanisms, hormones and brain rewards

1:16:15 - Thinking of & troubleshooting the body as a slowly self-learning software

1:21:20 - Why using food processing in a negative connotation is a limited way of thinking

1:24:35 - A discussion about sweeteners: erythritol and aspartame

1:28:33 - The benefit of not nuking your palate with sweeteners

1:34:46 - The bigger picture, living a happy life and lessons we can obtain from evolution

1:45:44 - Final Plugs

Guest Links

Ketogeek Links:

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