
What’s really changed after six years of Disrupting Japan
09/14/20 • 20 min
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How this silkworm startup is taking on the pandemic
Bio-tech is messy because life is complicated. A lot of attention is given to computers sequencing genomes, but some of the most advanced and important work is done by studying and using other living things to make our own lives better. Kenta Yamato co-founded Kaico to commercialize a technique that uses silkworms to manufacture small-batch custom proteins. And Kico is involved with everything from veterinary medicine to Japan's search for a coronavirus vaccine. We also talk about the challenges or creating startups based on university technology and the one e-commerce model in Japan that just won't go away. I think you'll enjoy the conversation. Show Notes How to get proteins from a silkworm (It's not fun for the silkworm) Why silkworms, in particular, must be used The importance and uses of small-batch, custom proteins The start of a silkworm startup The most common (and least successful) Japanese e-commerce model Why it's so hard for Japanese universities to spin-out startups How Kaico silkworms are part of the fight against covid-19 How to scale a silkworm startup Links from the Founder Everything you ever wanted to know about Kaico Friend Kenta on Facebook Connect with him on LinkedIn A Kaico video explainer Leave a comment Transcript Welcome to Disrupting Japan, straight talk from Japan's most successful entrepreneurs. I'm Tim Romero and thanks for joining me. Today, we're going to be talking about worms. No, no, wait, don't go, I promise this is going to be really interesting. Today, we're going to sit down and talk with Kenta Yamato of Kaico, a Kyushu-based startup that is using silkworms to rapidly produce custom small-batch innovative proteins that are used for bio-research, medicine, and they play a part in Japan's search for coronavirus vaccine. It's a fascinating process but admittedly one that's not particularly fun for the silkworms themselves. We also talk about the most popular and most unsuccessful e-commerce business model in Japan, the challenges Japanese universities in spinning out startups, and we even cover some practical solutions to that problem. But you know, Kenta tells that story much better than I can, so let's get right to the interview. Interview Tim: So I'm sitting here with Kenta Yamato of Kaico, a company that uses silkworm to produce specific protein used in medical tests and vaccine, and thank you for sitting down with me. Kenta: Yes, thank you for me and I have a very pleasure to explain our company's story. Yeah, thank you very much. Tim: It's great to have you on the show. I tried to explain very briefly what Kaico does, but I think you can explain it a lot better than I can, so at like a high level, what does Kaico do? Kenta: We started Kaico two years ago in 2018. Kaiko means silkworm in English. Maybe you know silkworm can make silk for clothes, but we will use this kaiko silkworm for making proteins. We are a startup company from Kyushu University and our products are many proteins, the protein the other companies cannot make because it is difficult to make it. We make this protein by silkworm. Tim: So if I understand the basic process, you inject the silkworm with a virus containing the target gene, and then it makes the proteins as part of its silk, and then you extract the proteins from the silk? Kenta: No, no. First, we'll incorporate the gene of target protein into baculovirus, so this baculovirus is safe for us humans and animals, but baculovirus damage to only silkworms and we will insert this recombinant baculovirus into silkworm and their body can make the specific protein in their cell, and finally, we'll collect and purify the body liquid from the silkworm. Tim: Okay, so it's not from the silk, it's from the silkworms themselves that you extract the proteins. Kenta: Yes, we don't use silk. Tim: Okay. So why silkworm? Is there something about silkworms that makes it easy to generate protein...
Next Episode

The Dream of Flying Cars meets the Truth of Aviation Startups
Personal aviation is awesome! Aviation has been a source of inspiration and a symbol of innovation since the Wright brothers' first flight at Kitty Hawk, to Neil Armstrong's first steps on the moon, to today's dreams of colonizing Mars. Unfortunately, it's been very hard for startups to make money in aviation. Even the Wright brothers did not do particularly well in business. But things might be changing. Today we sit down and talk with Tasuku Nakai, co-founder of Tetra Aviation, and we discuss how public research incentives, support from the aerospace giants, and the changing infrastructure needs might have just tipped the balance to startups. It's a great conversation, and I think you'll enjoy it. Show Notes How Tetra's eVTOL aircraft came to be and what it might become The steps needed to bring a new aircraft to market Why it's so difficult to innovate in aviation The main hurdle in expanding the personal aviation market Fundraising strategies and exist options for aviation startups When investing is considered "evil" in Japan Links from the Founder Everything you ever wanted to know about Tetra Aviation Friend Tasuku on Facebook Connect with him on LinkedIn Follow Tetra on Twitter @Tetra_Aviation Check out a video of their prototype VTOL aircraft Leave a comment Transcript Welcome to Disrupting Japan, straight talk from Japan's most successful entrepreneurs. I'm Tim Romero and thanks for joining me. Today, we’re going to talk about flying cars. That’s right, flying cars. We sit down with Tasuku Nakai, co-founder of Tetra Aviation and we talk about what it takes to bring a new aircraft, especially a new personal aircraft to market, and it’s not easy. The Tetra Aircraft is an electric vertical take-off and landing, or VTOL aircraft, which they believe will form the backbone of a new aerial intercity transport system. You know, I have a real soft spot for these kinds of startups. I have a private pilot’s license and I love the idea that the age of affordable personal aircraft might almost be here. But as I mentioned, it’s hard, and as Tasuku explains, these kinds of companies don’t fit the traditional VC model for a number of reasons. We also talk about the possible business models open to aircraft startups, the release of Tetra’s new prototype, and the crazy world of experimental aircraft pilots who fly newly designed aircraft as a hobby. But you know, Tasuku tells that story much better than I can, so let’s get right to the interview. Interview Tim: So, I’m sitting here with Tasuku Nakai of Tetra Aviation who makes personal electric aircraft, so thanks for sitting down with me. Tasuku: Thanks for inviting me, Tim, and this is a really great moment to introduce myself and introduce my business. Tim: No, the pleasure’s all mine. I think what you guys are doing is really interesting and I’ve had a passion for, like, aerospace startups for a long time, so actually, I mean, you can probably explain what Tetra Aviation is and what the product is better than I can. So basically, what are you building? Tasuku: We are building personal electrical VTOL aircraft, so vertical take-off and landing, so wherever you want to come, just simply ride on it and fly to the air and arrive on your destination exactly. Tim: And we’ll talk about the history later. This is kind of like the flying cars that startups have been teasing us about since the 1950s, but what you’ve built, is it considered an airplane or a helicopter, or a drone, or how is it classified? Tasuku: Well, a really difficult question about that. There’s no category anymore. There’s a lot of class, almost 50 or 60 classifications, but basically, you think it’s similar for helicopter and the drone, to combine the helicopter and drone, so I mean, the people can ride on it and also, it has a distributed propulsion system as a drone has. Tim: Actually, just today,
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