Episode #153: Leslie Kenny: The Hallmarks of Aging and Polyamines
05/16/23 • 74 min
While you may be familiar with the nine hallmarks of aging, over the past several years there have been an additional five added to that list. It might seem overwhelming to have 14 aging processes to keep up with, but it's important to understand that many of them, if not all of them, are essentially interrelated.
One thing we’ve learned about these processes that drive aging are that they are done at a cellular and systemic level. This gives us the opportunity to try and intercept and correct them so that we can live longer, healthier lives.
I’m joined by Leslie Kenny, Founder of Oxford Healthspan and Co-Founder of the Oxford Longevity Project. We’re talking all about the hallmarks of aging, including how the processes are interconnected, and what we can do to slow these processes down. We also dive into polyamines, specifically spermidine, and how it can boost autophagy.
Leslie Kenny is an autoimmune survivor/thriver, certified health coach and Founder and CEO of Oxford Healthspan, bringing to consumers the latest scientifically based molecules proven to slow aging.
She is also the Co-Founder of the non-profit Oxford Longevity Project which aims to bring the latest scientific breakthroughs on healthy aging to the general public. Leslie holds degrees from Berkeley and Harvard.
What we discuss:
00:01:38 - The symposiums and organizations Leslie is connected to
00:11:21 - The first nine hallmarks of aging
00:15:25 - Inflammation, gut dysbiosis, and autophagy
00:22:22 - The effects of fasting on the body
00:30:09 - The dysregulated RNA process
00:36:03 - What are polyamines?
00:44:42 - How do people get polyamines into their diet?
00:51:40 - Synthetics vs. food derived
00:57:17 - The benefits of spermidine supplements
Key Takeaways:
- Polyamines are derived from amino acids, and they play a role in slowing down the process of aging. The most well known polyamine is spermidine, and it helps to boost autophagy.
- There are many other molecules in foods and whole food sources, so it is important to consume nutrients through eating whole foods.
- The body is able to regenerate and self renew itself if we're able to remove the obstacles and facilitate those processes.
- Leslie’s top suggestions for longevity include eating intentionally, joyful movement, sleep, and early morning sunlight.
Find more from Nathalie:
YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ
Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance
Instagram: https://www.instagram.com/nathalieniddam/
Website: NatNiddam.com
Join Nat’s Membership Community: https://www.natniddam.com/bsp-community
Work with Nat: Book Your 20 MInute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08
Find more from Leslie Kenny:
Website: www.oxfordhealthspan.com
Instagram: @oxfordhealthspan, @lesliesnewprime, @oxfordlongevityproject
LinkedIn: https://www.linkedin.com/company/68855978
https://www.linkedin.com/company/oxford-longevity-project/
https://www.linkedin.com/in/leslie-k-28435a/
Thank you to our sponsors for making this episode possible:
Primeadine: Use promo code BIONAT15 to save 15% off your first purchase at https://oxfordhealthspan.com/products/best-spermidine-supplement
Berkeley Life: Use my code NIDDBL for 10% off at berkeleylife.com
While you may be familiar with the nine hallmarks of aging, over the past several years there have been an additional five added to that list. It might seem overwhelming to have 14 aging processes to keep up with, but it's important to understand that many of them, if not all of them, are essentially interrelated.
One thing we’ve learned about these processes that drive aging are that they are done at a cellular and systemic level. This gives us the opportunity to try and intercept and correct them so that we can live longer, healthier lives.
I’m joined by Leslie Kenny, Founder of Oxford Healthspan and Co-Founder of the Oxford Longevity Project. We’re talking all about the hallmarks of aging, including how the processes are interconnected, and what we can do to slow these processes down. We also dive into polyamines, specifically spermidine, and how it can boost autophagy.
Leslie Kenny is an autoimmune survivor/thriver, certified health coach and Founder and CEO of Oxford Healthspan, bringing to consumers the latest scientifically based molecules proven to slow aging.
She is also the Co-Founder of the non-profit Oxford Longevity Project which aims to bring the latest scientific breakthroughs on healthy aging to the general public. Leslie holds degrees from Berkeley and Harvard.
What we discuss:
00:01:38 - The symposiums and organizations Leslie is connected to
00:11:21 - The first nine hallmarks of aging
00:15:25 - Inflammation, gut dysbiosis, and autophagy
00:22:22 - The effects of fasting on the body
00:30:09 - The dysregulated RNA process
00:36:03 - What are polyamines?
00:44:42 - How do people get polyamines into their diet?
00:51:40 - Synthetics vs. food derived
00:57:17 - The benefits of spermidine supplements
Key Takeaways:
- Polyamines are derived from amino acids, and they play a role in slowing down the process of aging. The most well known polyamine is spermidine, and it helps to boost autophagy.
- There are many other molecules in foods and whole food sources, so it is important to consume nutrients through eating whole foods.
- The body is able to regenerate and self renew itself if we're able to remove the obstacles and facilitate those processes.
- Leslie’s top suggestions for longevity include eating intentionally, joyful movement, sleep, and early morning sunlight.
Find more from Nathalie:
YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ
Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance
Instagram: https://www.instagram.com/nathalieniddam/
Website: NatNiddam.com
Join Nat’s Membership Community: https://www.natniddam.com/bsp-community
Work with Nat: Book Your 20 MInute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08
Find more from Leslie Kenny:
Website: www.oxfordhealthspan.com
Instagram: @oxfordhealthspan, @lesliesnewprime, @oxfordlongevityproject
LinkedIn: https://www.linkedin.com/company/68855978
https://www.linkedin.com/company/oxford-longevity-project/
https://www.linkedin.com/in/leslie-k-28435a/
Thank you to our sponsors for making this episode possible:
Primeadine: Use promo code BIONAT15 to save 15% off your first purchase at https://oxfordhealthspan.com/products/best-spermidine-supplement
Berkeley Life: Use my code NIDDBL for 10% off at berkeleylife.com
Previous Episode
Episode #152: Lauren Berlingeri: Infrared Saunas & Red Light Therapy
What if there was a way to help detox your body, boost your mood, burn calories, and get glowing skin in just under 45 minutes a day? The good news is that there is, and my guest today is sharing the secret to elevating your at-home wellness routine.
Today we’re diving into the world of infrared, PEMF, and red light and discussing the many benefits of infrared saunas.
I’m joined by Lauren Berlingeri, one of the founders of HigherDOSE. Lauren is discussing her background and what inspired her to start HigherDOSE, and explaining some of the differences between infrared saunas and traditional heat saunas. She shares everything you need to know about when and how to use an infrared sauna, plus some of the benefits of detoxing daily.
As a female biohacker, Lauren is passionate about inviting more people into the biohacking world and reimagining these tools for all bodies — so you can reconnect with your intuition and elevate to your highest state. She is making it sexy to sweat it out and even hotter to know the science behind what’s happening. She is harnessing the healing power of nature and fitting it into busy, overstressed schedules. And, she is changing the way you think about beauty and wellness by building tools that ignite vitality from the inside out.
What we discuss:
00:00:50 - What inspired Lauren to start Higher Dose
00:06:53 - Infrared vs. regular heat
00:13:09 - How to prepare your body before going into an infrared sauna
00:20:46 - Why you should detox daily
00:25:04 - Lauren’s favorite three biohacks
00:33:00 - The best time to use an infrared sauna
00:38:14 - Research around menopausal women and red light
00:44:10 - Pros and cons of the sauna blanket
00:53:47 - How long should you use the sauna blanket?
01:00:30 - Other HigherDOSE products
Key Takeaways:
- Infrared saunas heat the body at a much lower temperature, so it's much more gentle on the body.
- The four main happy chemicals are dopamine, oxytocin, serotonin, and endorphins, and they are released with the use of infrared saunas.
- Before using an infrared sauna, it’s important to prepare your body by opening up your detox pathways.
Find more from Nathalie:
YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 MInute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08
Find more from Lauren Berlingeri:
Website: https://higherdose.com/
Instagram: @laurenberlingeri, @higherdose
Thank you to our sponsors for making this episode possible:
HigherDose: To save 15% sitewide on any of the great HigherDose products just go to bit.ly/HDNAT15 and use code NAT15.
Mitopure: Use code NAT10 for 10% off your order at https://www.timelinenutrition.com/shop/nutrition.
LMNT: Use Drinklmnt.com/NAT to get 8 free single serves with any order to try different flavors.
Profound Health: You can purchase Bioregulator Peptides and other great supplements at Profound-health.com and use promo code Longevity15 to save 15% on your first order.
Next Episode
Episode #154: Danielle LaPorte: Nervous System Regulation, Spirituality, and the Pursuit of Longevity
Did you know there is a connection between spirituality, a balanced nervous system and longevity? When it comes to biohacking, we focus primarily on the supplements we can take, the peptides we can use, and the different technology we can implement into our daily life. But, what many of us forget, is that our mental wellbeing plays a huge role in our health. We can do all the biohacks we want, but if our mental health is not balanced, we’ll struggle to optimize our health and longevity...plus, the brain-gut connection is a real thing!
My guest today is here to discuss why there’s more to the pursuit of longevity than just biohacks and supplements.
I’m joined by Danielle LaPorte, and we’re diving into the spiritual side of longevity and covering the corollary between the spiritual striving and the physical striving. We also discuss why a person's health history can be the key to healing, things you can do to eliminate any obstacles within your body, and how to balance your sympathetic nervous system with your parasympathetic nervous system.
Danielle LaPorte is a member of Oprah’s SuperSoul 100 a group who, in Oprah Winfrey’s words, “is uniquely connecting the world together with a spiritual energy that matters.” Danielle is the creator of the Heart Centered Membership and the Heart Centered Leadership Program with 400+ leaders in 30 countries hosting conversation circles, retreats, and workshops in all kinds of communities and businesses.
What we discuss:
00:03:18: The light side and the shadow side of our obsession and pursuit of longevity
00:09:43: The corollary between the spiritual striving and the physical striving
00:14:36: The metaphors of the body
00:19:24: The correlation between pain and fear
00:26:01: The misperception that spiritual people are healthy all the time
00:35:16: Why going through a person's health history can be the key to healing
00:41:19: Why your entire life needs to revolve around regulating your nervous system
00:49:35: When we start to think differently, we will attract the right kind of healthcare providers
00:55:22: By accessing the energetic force within yourself, you can eliminate any obstacles within your body
Thank you to our sponsors for making this episode possible:
Primeadine: Use promo code BIONAT15 to save 15% on your first order at https://oxfordhealthspan.com/products/best-spermidine-supplement
Sensate: Use code NAT to get 10% off at https://bit.ly/NatNiddam
LVLUP: Use code NAT10 to save 10% off at https://lvluphealth.com/
Find more from Nathalie:
YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 MInute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08
Find more from Danielle LaPorte:
Website: https://daniellelaporte.com/
Instagram: @daniellelaporte
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