Beyond Heartburn: Probing the Association Between Proton Pump Inhibitor and Dementia

In this episode In this illuminating episode, we dive deep into the world of proton pump inhibitors (PPIs), commonly prescribed medications for heartburn and acid reflux. While these drugs have brought relief to millions worldwide, recent studies have begun to uncover potential links between PPI use and an increased risk of dementia. We explore the mechanisms that might underlie this association, the clinical implications for patients, and the broader question of how seemingly unrelated conditions might be connected at a molecular level. Whether you're a healthcare professional, a patient on PPIs, or simply someone curious about the intricate web of human health, this episode promises to offer fresh insights into a hotly debated area of medicine.

References:

Main papers disucssed in this episode:

Northuis, Carin, et al. "Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study." Neurology (2023).

https://n.neurology.org/content/early/2023/08/09/WNL.0000000000207747?utm_source=twitter&utm_medium=organic

Gomm, Willy, et al. "Association of proton pump inhibitors with risk of dementia: a pharmacoepidemiological claims data analysis." JAMA neurology 73.4 (2016): 410-416.

https://jamanetwork.com/journals/jamaneurology/article-abstract/2487379

Li, Min, et al. "Proton pump inhibitor use and risk of dementia: systematic review and meta-analysis." Medicine 98.7 (2019).

Ortiz-Guerrero, Gloria, et al. "Proton pump inhibitors and dementia: physiopathological mechanisms and clinical consequences." Neural plasticity 2018 (2018).

Wijarnpreecha, Karn, et al. "Proton pump inhibitors and risk of dementia." Annals of translational medicine 4.12 (2016).

Haenisch, Britta, et al. "Risk of dementia in elderly patients with the use of proton pump inhibitors." European archives of psychiatry and clinical neuroscience 265 (2015): 419-428.

Batchelor, Riley, et al. "Dementia, cognitive impairment and proton pump inhibitor therapy: a systematic review." Journal of gastroenterology and hepatology 32.8 (2017): 1426-1435.

Gray, Shelly L., et al. "Proton pump inhibitor use and dementia risk: Prospective population‐based study." Journal of the American Geriatrics Society 66.2 (2018): 247-253.

Ahn, Nayeon, et al. "Do proton pump inhibitors increase the risk of dementia? A systematic review, meta‐analysis and bias analysis." British Journal of Clinical Pharmacology 89.2 (2023): 602-616.

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