Circulating Tumor Cells | Dr. Dan Rubin | Ryan Sternagel
01/21/21 • 57 min
show notes @ https://thesternmethod.com/circulatingtumorcells/
KEY TAKEAWAYS
1.
What are CTCs and what do they mean?
- Cells from a collection of cancer cells, tumor or metastatic deposit
- Sometime seen on scans but not always
- Circulate in the blood or lymphatic tissues
- Can only test for the CTC in blood. Need biopsy to detect in lymphatic tissue
- The presence of CTCs doesn’t necessarily indicate metastatic cancer
- CTCs don’t live very long in the blood – persistent CTC is cause for concern Cancer spreads in two ways
- Metastasize (means “evil spread”) - cells travel via blood vessels
- Direct invasion - cells invade the tissues and then access lymphatic system or blood stream What to look for in CTC testing
- Only available for certain cancers – ovarian, pancreatic, colon, lung, breast, prostate
- Looking for two different populations of CTCs- cytokeratin(CK)-positive and CK-negative
- ➔ CK is an anchor molecule for cells
- ➔ CK-negative cells are cells that have down regulated their CK and can leave the tissue space to ‘circulate’ as a CTC
- ➔ CK-positive cells are rarely found in CTC tests unless through trauma or if the tumor is invasive
- ➔ CK-negative cells can revert back to CK-positive and “anchor in” to a new tissue site
- Test results provide highly individual information about that person’s specific tumor
- Can also see some markers you’d see on pathology specimens - things that sit on the surface of cells such as androgen and estrogen receptors Hosted By:
2.
3.
29
- When to test for CTCs
- At diagnosis and before treatment, when cancer is the highest
- During treatment to gauge therapeutic response
- Post treatment testing to determine if cancer is still present or to identify recurrences
- What to do with CTC test results
- Depends on the patient – their history, the cancer, how aggressive, treatment proto- cols undertaken. Every situation/person is different
- Run other lab tests to look at supporting factors in the blood and fix those: ➔ Inflammatory markers ➔ Cell markers ➔ Immune markers ➔ Tissue markers ➔ Hormones ➔ Tissues at risk – liver, lung, bones ➔ Nutrient levels ➔ Vitamin D – 25-Hydroxy and 1,25-Dihydroxy ➔ Look at lifestyle – diet, toxins, air, water
- Goal is to shut down the flow of CTC into the blood CASE STUDIES / CLINICAL EXAMPLES / DIAGNOSES REFERENCED Breast cancer Colon cancer Lung cancer Ovarian cancer Pancreatic cancer Prostate cancer STUDIES / ARTICLES / CLINICAL TRIALS REFERENCED
N/A
BOOKS REFERENCED
N/A
Hosted By:
30
SUPPLEMENTS REFERENCED
N/A
THERAPIES REFERENCED
IV Vitamin C IV Quercetin Mistletoe therapy
OTHER RESOURCES
Biocept
FOLLOW DR RUBIN
Listenandcare.com Aspenmedcenter.com PH: 480.990.1111 Remote consultations available
show notes @ https://thesternmethod.com/circulatingtumorcells/
KEY TAKEAWAYS
1.
What are CTCs and what do they mean?
- Cells from a collection of cancer cells, tumor or metastatic deposit
- Sometime seen on scans but not always
- Circulate in the blood or lymphatic tissues
- Can only test for the CTC in blood. Need biopsy to detect in lymphatic tissue
- The presence of CTCs doesn’t necessarily indicate metastatic cancer
- CTCs don’t live very long in the blood – persistent CTC is cause for concern Cancer spreads in two ways
- Metastasize (means “evil spread”) - cells travel via blood vessels
- Direct invasion - cells invade the tissues and then access lymphatic system or blood stream What to look for in CTC testing
- Only available for certain cancers – ovarian, pancreatic, colon, lung, breast, prostate
- Looking for two different populations of CTCs- cytokeratin(CK)-positive and CK-negative
- ➔ CK is an anchor molecule for cells
- ➔ CK-negative cells are cells that have down regulated their CK and can leave the tissue space to ‘circulate’ as a CTC
- ➔ CK-positive cells are rarely found in CTC tests unless through trauma or if the tumor is invasive
- ➔ CK-negative cells can revert back to CK-positive and “anchor in” to a new tissue site
- Test results provide highly individual information about that person’s specific tumor
- Can also see some markers you’d see on pathology specimens - things that sit on the surface of cells such as androgen and estrogen receptors Hosted By:
2.
3.
29
- When to test for CTCs
- At diagnosis and before treatment, when cancer is the highest
- During treatment to gauge therapeutic response
- Post treatment testing to determine if cancer is still present or to identify recurrences
- What to do with CTC test results
- Depends on the patient – their history, the cancer, how aggressive, treatment proto- cols undertaken. Every situation/person is different
- Run other lab tests to look at supporting factors in the blood and fix those: ➔ Inflammatory markers ➔ Cell markers ➔ Immune markers ➔ Tissue markers ➔ Hormones ➔ Tissues at risk – liver, lung, bones ➔ Nutrient levels ➔ Vitamin D – 25-Hydroxy and 1,25-Dihydroxy ➔ Look at lifestyle – diet, toxins, air, water
- Goal is to shut down the flow of CTC into the blood CASE STUDIES / CLINICAL EXAMPLES / DIAGNOSES REFERENCED Breast cancer Colon cancer Lung cancer Ovarian cancer Pancreatic cancer Prostate cancer STUDIES / ARTICLES / CLINICAL TRIALS REFERENCED
N/A
BOOKS REFERENCED
N/A
Hosted By:
30
SUPPLEMENTS REFERENCED
N/A
THERAPIES REFERENCED
IV Vitamin C IV Quercetin Mistletoe therapy
OTHER RESOURCES
Biocept
FOLLOW DR RUBIN
Listenandcare.com Aspenmedcenter.com PH: 480.990.1111 Remote consultations available
Previous Episode
Pancreatic & Protelytic Enzymes, Metabolic Typing & Coffee Enemas | Mary Swander, Author: The Maverick M.D.: Dr. Nicholas Gonzalez & Ryan Sternagel
Show notes at https://thesternmethod.com/mary-swander
Mary Swander is an award-winning American author, dramatist, performer, speaker, and teacher. She is the former Poet Laureate of Iowa and a professor emerita Distinguished Professor of Iowa State University.
Mary is the Artistic Director of Swander Woman Productions, a theatre troupe that performs dramas about food, farming, and the wider rural environment. She is also the Executive Director of AgArts, a nonprofit designed to imagine and promote healthy food systems through the arts. Her latest book is The Maverick M.D.: Dr. Nicholas Gonzalez and His Fight for a New Treatment for Cancer (New Spring Press).
The Maverick M.D. is the story of how Dr. Nick Gonzalez perfected the scientific theory behind Dr. William Kelley's work and put the protocol into practice in New York City. Gonzalez drew courage from his Christian faith, from Mexican-Italian-American family, and from key loved ones, colleagues and mentors.
He spent years treating patients with the most serious conditions--from cancer to diabetes to lupus. But he wasn't satisfied as an outlier in the medical community. He wanted his work put to the test with a clinical trial.
This book portrays a man who fought for the acceptance of a nutritional cancer treatment in the halls of some of the most established U.S. medical institutions. Against intense opposition, Nick Gonzalez's determination held up until the end--a scientist who developed a therapy that saves lives and promotes the healing of the human mind, body and spirit.
***Resources Mentioned***Agarts: Imagine a healthy food system
Nutricology Pancreas Pork Natural Glandular Capsules
Nutricology ImmoPlex Natural Glandulars
The Nicholas Gonzalez Foundation
***
In This Episode:Ryan takes a candid look at Dr. Nicholas Gonzalez’s life and “the man behind the suit” in the discussion with his biographer, Mary Swander. You’ll learn about why Ryan thinks so highly of Dr. Gonzalez, his life and personality, the Gonzalez Protocol and the results it produced. Ryan and Mary delve into Dr. Gonzalez’s attempts to take his enzyme therapy protocol to clinical trials in the conventional medical arena. They also discuss Mary’s experience as a patient of Dr. Gonzalez for over 20 years. You’ll gain insight into the brilliant mind of Dr. Gonzalez, his spiritual life, his concept of balance, and his mysterious death. And speaking of brilliant minds...at the end, you’ll be treated to a special creation by Ryan’s son, Ryder!
Timestamps:
2:35 How Ryan learned about Dr. Nicholas Gonzalez
- Dr. Gonzalez was speaking at The Truth About Cancer conference
- Smartest guy in the whole field - genius
- Didn’t consider himself an integrative medical practitioner
- Helping people with cancer and other degenerative diseases
- Ivy-league doctor, traditional medical training
5:15 What was the paradigm shift which caused Dr. Gonzalez to go into the realm of unconventional medicine?
- His two loves : literature/arts and medicine
- Accomplished investigative journalist - worked for Time, Inc.
- Linus Pauling encouraged him to go to medical school after an interview
- Sloan Kettering Medical School
- When Dr. Gonzalez’s father got cancer, he stood beside his father’s death-bed and vowed he would find a cure for cancer.
- Met dentist William Kelley who had cured himself from pancreatic cancer
- Dr. Gonzalez wanted to know how Dr. Kelley cured himself and his patients - went to Texas to investigate how
- Came back to Sloan Kettering and tried to prove Dr. Kelley’s method in the conventional setting
- Wanted clinic trials but conventional medicine wasn’t cooperative
- Dr. Gonzalez had family in Mexico and could have gone there to practice alternative medicine but wanted to stay in the US.
11:45 Mary Swander’s experience as a patient of Dr. Gonzalez
- Dr. Gonzalez passed away in 2015
- MaryBeth Gonzalez (widow) has worked hard to keep his legacy alive
- Mary Swander was patient of Dr. Gonzalez for 20 years
- Group of scientists with breast cancer wanted to work with Dr. Gonzalez to heal metastasis <...
Next Episode
Methionine restricted diet | Sodium selenite | NORI Protocol | Mark Simon & Ryan Sternagel
Full show notes @ https://thesternmethod.com/mark-simon/ Mark Simon, CN, CHCC, CPBN
Mark Simon established the Nutritional Oncology Research Institute (NORI) in 2011 as an organization focused on advancing cancer care through optimization of diet and application of targeted nutraceuticals. Mark Simon's background and interests are in diverse fields including clinical nutrition, biomedical engineering, plant-based nutrition, naturopathic medicine and neuroscience.
***Resources Mentioned***
Nutritional Oncology Research Institute
NORI PROTOCOL - methionine video by Dr. Mark Gregor
Fruit, The Lymphatic System & Cancer: Dr. Robert Morse
Book: Fit for Life by Harvey Diamond
Scientific papers on Methionine, Sodium Selenite, Vit E, Melatonin
Nutritional Oncology Research Institute - Cbd, Hemp CBD, Hemp
NORI CBD - Cbd, Cbd, Alternative Health Products, Cbd Oil
Nutritional Oncology Research Institute - Home
Pure Organic Super-Greens Powder
Algae Omega-3 Oil, 400 mg DHA per ml
https://norinutraceuticals.com/shop/ols/products/selenium
Zinc Chelate, 15 mg, 90 tablets
Vitamin D3, 2,000 IU, 360 tablets
Sublingual Vitamin B12, 500 micrograms Methylcobalamin, 120 Tablets
1 oz. Organic Broccoli and Radish Sprout Powder (High Sulforaphane Content)
Vitamin E Delta, Gamma Tocotrienols, Annatto Derived (DeltaGold), 60 ml, 21,000 mg
Glucosamine HCl Powder, 8 oz., 227 grams
Sodium Selenite, 2 mg, 180 Slow Release Tablets
*Use code STERN at checkout to receive a discount
The Stern Method Website - What We Use:
Essential Oils We Use Including Our Targeted Blends
Cancer Fighting Tools for Detox and Cancer Fighting My Kid Cures Cancer
Anti-Cancer, Non-Toxic, Healthy Lifestyle Products We Use
***
In This Episode:Our guest today, Mark Simon, talks about how eating a low methionine diet can lead to better health and cancer cell death (apoptosis).
In this episode, Mark and Ryan discuss the benefits of a plant-based diet which is high in fruits a...
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