
Metabolism, Muscle, Hormones, and so much more, with Dr. Zack Roloff
08/07/24 • 176 min
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On this week's episode we have Zack Roloff, PhD - ABD at the University of Minnesota. Zack shares his expertise and ongoing research in muscle physiology and metabolism. DISCLAIMER: we do deeeeep into the molecular biology at the beginning of the episode, so if you aren't interested in those specifics, you can skip forward when we break it down in layman's terms. At around the 53 minute-mark, we summarize the research. Then at around 1 hour and 33 minutes we begin Reid's Reddit Read's and broaden our discussion to apply Zack's research to more concepts in the world of health and wellness.
Zack's is part of a lab that studies skeletal muscle physiology, specifically in terms of aging and sex hormones. Zack, however, is a bit of the black sheep (in a good way) within his lab. His research focuses on the relaxed states of skeletal muscle myosin and how those states are influenced by (or actually do the influencing of) metabolism. This is a very new and exciting area of research, and could change the way we think about metabolic diseases, obesity, type 2 diabetes, and all other areas of metabolism and thermogenesis.
We talk about calorie intake, the influence of biological sex on metabolic function, hormone replacement therapy, cold water immersion, muscle physiology, menopause, aging. There is truly something for everyone in this episode!!!
Follow us on social media @kickbackscience for more content!
Don't forget to visit our website: https://www.kickbackscience.com/ and sign up for the kickback science newsletter!
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Podcast: kickbackscience.buzzsprout.com/share
Send us a text! We'd love to hear what you think of the podcast!
On this week's episode we have Zack Roloff, PhD - ABD at the University of Minnesota. Zack shares his expertise and ongoing research in muscle physiology and metabolism. DISCLAIMER: we do deeeeep into the molecular biology at the beginning of the episode, so if you aren't interested in those specifics, you can skip forward when we break it down in layman's terms. At around the 53 minute-mark, we summarize the research. Then at around 1 hour and 33 minutes we begin Reid's Reddit Read's and broaden our discussion to apply Zack's research to more concepts in the world of health and wellness.
Zack's is part of a lab that studies skeletal muscle physiology, specifically in terms of aging and sex hormones. Zack, however, is a bit of the black sheep (in a good way) within his lab. His research focuses on the relaxed states of skeletal muscle myosin and how those states are influenced by (or actually do the influencing of) metabolism. This is a very new and exciting area of research, and could change the way we think about metabolic diseases, obesity, type 2 diabetes, and all other areas of metabolism and thermogenesis.
We talk about calorie intake, the influence of biological sex on metabolic function, hormone replacement therapy, cold water immersion, muscle physiology, menopause, aging. There is truly something for everyone in this episode!!!
Follow us on social media @kickbackscience for more content!
Don't forget to visit our website: https://www.kickbackscience.com/ and sign up for the kickback science newsletter!
Youtube: https://www.youtube.com/@KickbackScienceWithDrLuke?sub_confirmation=1
Facebook: facebook.com/kickbackscience
Instagram: instagram.com/kickbackscience?fbclid=IwAR1EhSV_iD-HQYpTJ7OFFU4wE0bSYxnaxbwsp1w2sSshuLFhuLvh88ogGTs
tiktok: tiktok.com/@kickbackscience?fbclid=IwAR2VFnxdQYgbRnCrou_nUPvs0-wbWZJUaGsVPTPZWmVBQeDVI1OtNWAyke4
Podcast: kickbackscience.buzzsprout.com/share
Previous Episode

STRENGTH: How to increase it, and why everyone should be doing it
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This week we break down the science related to strength training. We discuss the research on how to optimize your training to increase strength. We talk about the reps, sets, rest, frequency, type of workouts, recovery, progression, intensity, and supplements to get you as strong as possible.
We also talk about the impressive research showing how strength is one of the best metrics for health and longevity. We discuss how to improve strength at any age (even in your 90's), and why everyone should care about how strong they are. You'll be amazed at the impact that strength has on all aspects of your health.
Kick back and listen! If you find the podcast content interesting, please like, share, subscribe, and follow! You can also submit feedback, comments, questions, or request the next podcast topic on our website (www.kickbackscience.com). We will answer submitted questions live during the podcast episodes!
Next Episode

Debunking the "Fat Burning Zone" Myth
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Have you ever been told that exercising at lower intensities will burn more fat? Or that you shouldn't do high intensity exercise if you're stressed out, because the added stress isn't good for your body?
These claims are pretty common in the fitness industry.. BUT THEY ARE SO WRONG!!! In this episode we debunk this common "fat burning zone" myth, and explain why high intensity exercise is awesome! At least according to the science..
Follow us on social media @kickbackscience for more content!
Don't forget to visit our website: https://www.kickbackscience.com/ and sign up for the kickback science newsletter!
Youtube: https://www.youtube.com/@KickbackScienceWithDrLuke?sub_confirmation=1
Facebook: facebook.com/kickbackscience
Instagram: instagram.com/kickbackscience?fbclid=IwAR1EhSV_iD-HQYpTJ7OFFU4wE0bSYxnaxbwsp1w2sSshuLFhuLvh88ogGTs
tiktok: tiktok.com/@kickbackscience?fbclid=IwAR2VFnxdQYgbRnCrou_nUPvs0-wbWZJUaGsVPTPZWmVBQeDVI1OtNWAyke4
Podcast: kickbackscience.buzzsprout.com/share
References:
High intensity resulted in better body composition and glycemic control compared to moderate intensity: https://doi.org/10.1111/dom.13198
High intensity has greater mitochondrial adaptations: https://doi.org/10.1113/JP272570
High intensity results in more fat oxidation ("fat burning"): https://doi.org/10.1007/s00421-020-04409-2
Meta analysis showing the millions of benefits of high intensity exercise compared to moderate: https://pubmed.ncbi.nlm.nih.gov/35859145/
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