
Leading the Anti-Aging Revolution
11/28/18 • 44 min
Our guest today needs no introduction. It is the one and only Aubrey de Grey, a leading biomedical gerontologist, computer scientist, author, and entrepreneur whose work in longevity research is widely known and regularly referenced by many in the industry. He is the Chief Science Officer of the SENS Research Foundation and VP of New Technology Discovery at AgeX Therapeutics, Inc. In many respects, Aubrey is one of the most prominent, if not provocative figures in longevity science.
What makes Aubrey so provocative? Well, aside from his exceptionally long beard, he is the leading advocate of the controversial view that technology may one day enable humans to control the aging process and live well into our hundreds, or even thousands. As much as he believes this, he also knows that there are two main obstacles to achieving this utopia: money and time. While Aubrey’s research is funded by some of the biggest investors, he notes that the “pro-aging trance” has historically held them back. This conversation with Aubrey uncovers the theory of his pro-aging trance phenomena and many incredibly insightful details, including:
- How to remove senescent cells from our body
- What investments are at the top of his list
- Why investor Peter Thiel gave him $6M in funding
- What locations are hot spots for longevity research and innovation
- Where he’s seen the biggest breakthroughs
- When we can expect to benefit from his research
- What is the “pro-aging trance” and why it’s holding us back
This was a really exciting episode that gave the team a chance to hear a unique perspective. We hope you enjoy the episode and share it with your friends, family, and colleagues.
About Aubrey Show LinksOur guest today needs no introduction. It is the one and only Aubrey de Grey, a leading biomedical gerontologist, computer scientist, author, and entrepreneur whose work in longevity research is widely known and regularly referenced by many in the industry. He is the Chief Science Officer of the SENS Research Foundation and VP of New Technology Discovery at AgeX Therapeutics, Inc. In many respects, Aubrey is one of the most prominent, if not provocative figures in longevity science.
What makes Aubrey so provocative? Well, aside from his exceptionally long beard, he is the leading advocate of the controversial view that technology may one day enable humans to control the aging process and live well into our hundreds, or even thousands. As much as he believes this, he also knows that there are two main obstacles to achieving this utopia: money and time. While Aubrey’s research is funded by some of the biggest investors, he notes that the “pro-aging trance” has historically held them back. This conversation with Aubrey uncovers the theory of his pro-aging trance phenomena and many incredibly insightful details, including:
- How to remove senescent cells from our body
- What investments are at the top of his list
- Why investor Peter Thiel gave him $6M in funding
- What locations are hot spots for longevity research and innovation
- Where he’s seen the biggest breakthroughs
- When we can expect to benefit from his research
- What is the “pro-aging trance” and why it’s holding us back
This was a really exciting episode that gave the team a chance to hear a unique perspective. We hope you enjoy the episode and share it with your friends, family, and colleagues.
About Aubrey Show LinksPrevious Episode

Investing in the Future of Human Longevity
Sonia Arrison – Author and Founder of 100 Plus Capital
Most of us watch reality TV shows to escape our responsibilities and indulge in something less than wholesome. Today's guest found something interesting nestled in her indulgence. While watching the Fox reality TV show The Swan, famed author and investor Sonia Arrison detected the pending human longevity revolution that was just around the corner. She began investigating the effects that increased human longevity would have on society, culminating in her book 100 Plus: How the Coming Age of Longevity Will Change Everything, From Careers and Relationships to Family and Faith.
While we at L200 are still wondering what it looks like to live to 200, Sonia literally wrote the book on what it means to live past 100. Sonia's interest in human longevity started long before her encounter with The Swan. As a young girl, she noticed that while her grandparents were aging quite well, others did not fare so well. This sparked her curiosity and set her on a lifelong journey in longevity science.
Today, Sonia and her team at 100 Plus Capital invest in some of the most innovative companies positively impacting human longevity. As an active investor, Board Member at the Thiel Foundation, and a Senior Fellow at the Fraser Institute, Sonia’s research and intuition delivers a unique perspective that proved highly-engaging in our conversation. During this podcast, we explore Sonia's investment focus, her diverse background, and her view on a number of interesting topics, including:
- What has changed since Sonia wrote her book
- Why longevity is good for economic growth
- What are the hot longevity topics at Silicon Valley cocktail parties
- What investment categories are interesting for Sonia
- Where she sees the most innovation
- How 911 changed her perspective on human health
- What Sonia thinks of the latest trends/fads (e.g. Keto, fasting)
This was an incredible episode that left our team feeling optimistic and energized. Be sure to catch the (new) lightning round at the end of the episode for Sonia’s take on the latest and greatest trends in healthy living!
About Sonia Show Links- Senolytics
- Daniel Kraft, MD
- Gerry Becker, The Economic Way of Looking at Life
- Implications of Population Aging for Economic Growth - David canning and David Bloom
- CIA longevity factbook
- The Ocean Cleanup
- L- nutra, ProLon
- Blumio
- 5-2 diet
- Parabiosis
- Aubrey de Grey
- UCSF Memory and Aging Center
- Johnson & Johnson Anti-Aging
- Calico
- Unity Biotechnology
Next Episode

Unlocking the Longevity Secrets of Man’s Best Friend
Matt Kaeberlein – Longevity Expert
Our guest today is Matt Kaeberlein, Ph.D., a globally recognized researcher and expert in the biology of aging. Dr. Kaeberlein’s research is based around the premise that understanding the molecular mechanisms of aging will lead to interventions that slow the onset and progression of age-related chronic conditions, such as cancer, diabetes, kidney disease, heart disease, Alzheimer’s and others. Dr. Kaeberlein received his Ph.D. from the Massachusetts Institute of Technology in 2002 advised by Leonard Guarente, and did his post-doctoral work with Stanley Fields in the Department of Genome Sciences at the University of Washington.
Dr. Kaeberlein’s expertise in dietary restriction, longevity genes for therapeutics, aging in dogs, and Rapamycin really shines in this conversation. We were lucky enough to really explore his background while sharing our collective love of dogs. The conversation explores many areas, including:
- What is the difference between calories restriction and dietary restriction
- What are the biggest challenges with the science
- How Matt thinks about tailored dietary advice
- Why Matt launched the Dog Aging Project
- What we can learn from his research with dogs
- What is Rapamycin and why he’s so interested in its effects
This conversation was incredibly illuminating and really fun. We hope you enjoy the episode and share it with your friends, family, and colleagues.
About Matt Show LinksIf you like this episode you’ll love
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