
CM#1: GLP-1 agonists: Anthony Castore talks with Chris Duffin
09/18/24 • 81 min
In this episode, we're diving deep into GLP-1 agonists, a topic that has sparked considerable debate within the fitness and health communities. Our special guest, Anthony Castor, brings a wealth of knowledge as the first non-physician to earn a fellowship with the Seed Scientific Research and Performance Institute. Together, we'll address controversies, debunk myths, and uncover the multi-faceted benefits of GLP-1 agonists far beyond their well-known role in weight loss and diabetes management.
We'll explore their neuroprotective effects, benefits in managing neurodegenerative diseases like Alzheimer’s and Parkinson’s, and their surprising impact on cognitive decline, addiction, and ADHD. Moreover, we'll break down complex mechanisms, historical context, and real-world applications in an easily digestible format. Stay tuned as we demystify GLP-1 agonists and reveal how they can enhance not only physical but also mental resilience. Anthony Castor, a health advocate and educator, delves into the intricate world of peptides and their multifaceted benefits.
With a passion for making complex biochemical processes understandable, Anthony focuses on the potent impacts of GLP-1 (glucagon-like peptide-1), GIP (gastric inhibitory polypeptide), and myelin, among others. By demystifying how these peptides interact and function together, Anthony aims to shift public perception and drive forward significant improvements in health. Known for his use of analogies to clarify scientific concepts, Anthony is committed to educating people on the transformative potential of these sophisticated biochemical tools. Anthony's
This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by
@naboso_technology : The Foundation of Movement. 🦶🏼Use Code RESILIENCE for 20% off your first order at https://www.naboso.com
@marekhealth : Performance. Longevity. Optimization. 🔬 Use code RESILIENCE for 10% off your first bloodwork at https://marekhealth.com/chrisduffin
Website: https://www.castoremethod.com
Instagram: https://www.instagram.com/anthonycastore/
Join Duffin Community & Education:
https://www.skool.com/endless-evolution-8560/about
www.chrisduffin.com
In this episode, we're diving deep into GLP-1 agonists, a topic that has sparked considerable debate within the fitness and health communities. Our special guest, Anthony Castor, brings a wealth of knowledge as the first non-physician to earn a fellowship with the Seed Scientific Research and Performance Institute. Together, we'll address controversies, debunk myths, and uncover the multi-faceted benefits of GLP-1 agonists far beyond their well-known role in weight loss and diabetes management.
We'll explore their neuroprotective effects, benefits in managing neurodegenerative diseases like Alzheimer’s and Parkinson’s, and their surprising impact on cognitive decline, addiction, and ADHD. Moreover, we'll break down complex mechanisms, historical context, and real-world applications in an easily digestible format. Stay tuned as we demystify GLP-1 agonists and reveal how they can enhance not only physical but also mental resilience. Anthony Castor, a health advocate and educator, delves into the intricate world of peptides and their multifaceted benefits.
With a passion for making complex biochemical processes understandable, Anthony focuses on the potent impacts of GLP-1 (glucagon-like peptide-1), GIP (gastric inhibitory polypeptide), and myelin, among others. By demystifying how these peptides interact and function together, Anthony aims to shift public perception and drive forward significant improvements in health. Known for his use of analogies to clarify scientific concepts, Anthony is committed to educating people on the transformative potential of these sophisticated biochemical tools. Anthony's
This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by
@naboso_technology : The Foundation of Movement. 🦶🏼Use Code RESILIENCE for 20% off your first order at https://www.naboso.com
@marekhealth : Performance. Longevity. Optimization. 🔬 Use code RESILIENCE for 10% off your first bloodwork at https://marekhealth.com/chrisduffin
Website: https://www.castoremethod.com
Instagram: https://www.instagram.com/anthonycastore/
Join Duffin Community & Education:
https://www.skool.com/endless-evolution-8560/about
www.chrisduffin.com
Previous Episode

Architect of Resilience #015: Steven Sashen talks with Chris Duffin
Welcome back to the "Architect of Resilience Podcast!" In today's episode, we're diving into a thought-provoking conversation between our host, Chris Duffin, and special guest, Steven Sashen. Together, they tackle the ongoing debate surrounding specialized footwear in strength sports, fitness, and overall musculoskeletal health.
We'll explore the evolution of footwear in disciplines like powerlifting and Olympic lifting, discussing the shift from traditional weightlifting shoes to minimalist options and even going barefoot. Our speakers will examine how these choices impact performance, agility, flexibility, and injury risk, emphasizing the importance of context and individuality in selecting the right gear.
Chris and Steven will also break down the biomechanics behind weightlifting shoes, the psychological effects of specialized footwear, and the balance between safety and optimal muscle engagement. They'll share personal anecdotes and reference upcoming research on minimalist footwear, foot strength, and its effects on balance and proprioception.
Check out Steven Sashen:
Website: http://www.sashen.com
LinkedIn: https://www.linkedin.com/in/sashen/
Xero Shoes: https://xeroshoes.com/about-us/
This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by
@naboso_technology : The Foundation of Movement. 🦶🏼 Use Code RESILIENCE for 20% off your first order at https://www.naboso.com
This episode is also sponsored by Build Fast Formula @buildfastformula: Build Smart. Build Strong. Build Fast. 💪🏼🧬 Use code RESILIENCE for 10% off your order at https://buildfastformula.com
ChrisDuffin.com Architect of Resilience podcast 🎙
Author | The Eagle & the Dragon 🦅🐉 📚
Award Winning Design Engineer ⚙️
Endless Evolution ♾️ #1000GrandGoals Squat-Dead 🎬
Next Episode

CM#2: Mitochondria As Powerhouse: Anthony Castore talks with Chris Duffin
Chris Duffin is joined by Anthony Castor for an in-depth exploration of mitochondrial health and the revolutionary role of peptides and supplements.
We'll cover the fascinating glucose lactate shuttle and how lactate can be repurposed as an energy source, particularly benefiting muscles and the brain. Discover how elite athletes harness the power of specific bacteria to optimize lactate usage. We’ll also delve into mitochondrial-enhancing peptides like Aicar and Mots-C, examining their impact on endurance, fat metabolism, and overall health.
From the role of carnitine in energy production to the advanced benefits of peptides like SS-31 and humanin, Chris and Anthony discuss practical applications and personal anecdotes to help you maximize your performance and well-being. We’ll touch on innovative peptide stacks for metabolic health, brain protection, and even potential treatments for chronic diseases.
Stay tuned to learn how supporting your mitochondria can transform everything from exercise recovery to cognitive function, and join our community for deeper insights and personalized guidance on your journey to resilience. Get ready to unlock the secrets of your cellular powerhouse with us!
Notable Mentions- Products and Supplements: Explore Mots-C, SS-31, Aicar, Humanin, CB-4211, and SBT-272.
- Exercise and Mitochondrial Health: The value of HIIT and traditional endurance training in boosting mitochondrial functions.
- Supporting Fat Utilization: Enhancing performance through optimized mitochondrial activity.
Anthony Castor developed a fascination with cellular biology after learning a captivating fact about mitochondria—that they are inherited exclusively from our mothers and come with their own unique DNA. This newfound knowledge ignited his interest in the critical functions of these cellular powerhouses. Anthony appreciates the intricate role mitochondria play, especially for individuals who regularly work out, and he is dedicated to sharing this information with others.
This episode of the ARCHITECT of RESILIENCE podcast is available on Apple, Spotify & YouTube, and is sponsored by
@naboso_technology : The Foundation of Movement. 🦶🏼Use Code RESILIENCE for 20% off your first order at https://www.naboso.com
@marekhealth : Performance. Longevity. Optimization. 🔬 Use code RESILIENCE for 10% off your first bloodwork at https://marekhealth.com/chrisduffin
Website: https://www.castoremethod.com
Instagram: https://www.instagram.com/anthonycastore/
Join Duffin Community & Education:
https://www.skool.com/endless-evolution-8560/about
www.chrisduffin.com
Architect of Resilience - CM#1: GLP-1 agonists: Anthony Castore talks with Chris Duffin
Transcript
Welcome to the architect of Resilience podcast, where we explore the secrets of overcoming life's challenges and unlocking unstoppable strength through. Deep personal conversations and expert insights. We have an entirely new series on the architect of Resilience podcast. I'm really excited about it because it's still under the same philosophy and it's about being more resilient through physiologically. And so there's been an area I've been playing in for about 20 yea
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