Ep. 134: “The Power of Organoids” Featuring Dr. James Wells

Guest: Dr. James Wells is the Director for Research in the Division of Endocrinology at Cincinnati Children's Hospital, as well as the Chief Scientific Officer at the Center for Stem Cell and Organoid Medicine (CuSTOM). His research focuses on understanding the embryonic development of the pancreas and gastrointestinal organs by identifying mechanisms involved in the embryonic development of endocrine cells. His translational projects include generating 3D human tissues from pluripotent stem cells to model diabetes and digestive disease. Resources and Links Creation of 3D Printed Implant for Spinal Cord Injuries - Researchers have succesfully 3D printed a two-millimeter spinal cord implant to repair spinal cord injuries in rats. Researchers Generate Human Naive Induced Pluripotent Stem Cells - A combination of microfluidics and modified RNA have been used to directly reprogram somatic cells into naive, rather than primed, hiPSCs. Cutting Off Melanoma's Escape Routes – Scientists have discovered stem cells which form blood vessels in tumors, and have identified how to switch the cells off, cutting off the blood supply. Endoglin as a Target for Acute Leukemia - A glycoprotein on the cell surface, called endoglin, is a marker for cancer stem cells in acute myeloid leukemia and acute B-lymphoblastic leukemia. Correcting the Genetic Mutation that Causes a Life-Threatening Autoimmune Syndrome - Researchers have developed a method for modifying blood stem cells to reverse the genetic mutation that causes IPEX syndrome. Photo Reference: Courtesy of Dr. James Wells #footable_5807 { font-family: inherit; font-size: 14px; } #footable_parent_5807 thead { display: none; } #footable_parent_5807 a.nt_edit_link { display: none; } #footable_parent_5807 td { border-color: #fff; } #footable_parent_5807 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_5808 { font-family: inherit; font-size: 14px; } thead { display: none; } #footable_parent_5808 a.nt_edit_link { display: none; } #footable_parent_5808 td { border-color: #fff; } #footable_parent_5808 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_7873 { font-family: inherit; font-size: 14px; } #footable_parent_7873 thead { display: none; } #footable_parent_7873 a.nt_edit_link { display: none; } #footable_parent_7873 td { border-color: #fff; } #footable_parent_7873 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_7874 { font-family: inherit; font-size: 14px; } #footable_parent_7874 thead { display: none; } #footable_parent_7874 a.nt_edit_link { display: none; } #footable_parent_7874 td { border-color: #fff; } #footable_parent_7874 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_5807 { font-family: inherit; font-size: 14px; } #footable_parent_5807 thead { display: none; } #footable_parent_5807 a.nt_edit_link { display: none; }