The Stem Cell Podcast

Guest: Dr. Clive Svendsen is the Director of the Board of Governors Regenerative Medicine Institute and Professor of Biomedical Sciences at Cedar Sinai Medical Center. One focus of his current research is to derive cells from patients with specific disorders, which can then be “reprogrammed” to a primitive state and used as powerful models of human disease. The other side of his research involves cutting edge clinical trials. Featured Resource: iCell® Human iPSC-Derived Products Resources and Links New Administration Budget Would Bludgeon Science Funding – Under President Donald Trump’s 2018 budget proposal, federal research spending would decline abruptly. Mouse Sperm Survive Trip to Space – Sperm freeze-dried and sent into space for months of exposure to high levels of solar radiation later produced healthy baby mice. 40 More Intelligence Genes Identified – By sifting through the genetics of nearly 80,000 people, researchers have uncovered 40 genes that may make certain people smarter which brings the total number of suspected “intelligence genes” to 52. Statin Drugs May Not Benefit Older Adults – This article reveals that statins did not cause a meaningful reduction in heart attacks, coronary heart disease deaths or deaths from any cause in people age 65 and older. Bookmarks on Stem Cells – Stem cells preserve their identities after cell division by using a series of protein “bookmarks” on their genes, according to new research published by scientists at Weill Cornell Medicine. High-Throughput Protocol for Deriving Microglia from Human Stem Cells – Scientists from the New York Stem Cell Foundation Research Institute have developed a robust, efficient method for deriving microglia, the immune cells of the brain, from human stem cells according to a paper published in Stem Cell Reports. HIV May Cause Emphysema by Taking Over Stem Cells – HIV may cause emphysema by reprogramming the stem cells, called basal cells, to produce enzymes that can destroy lung tissue. A Cure for Baldness? – Scientists have found that immune system cells that control inflammation play a key role in hair growth. Photo Reference: Courtesy of Dr. Clive Svendsen #footable_5807 { font-family: inherit; font-size: 14px; } #footable_parent_5807 thead { display: none; } #footable_parent_5807 a.nt_edit_link { display: none; } #footable_parent_5807 td { border-color: #fff; } #footable_parent_5807 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_5808 { font-family: inherit; font-size: 14px; } thead { display: none; } #footable_parent_5808 a.nt_edit_link { display: none; } #footable_parent_5808 td { border-color: #fff; } #footable_parent_5808 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_7873 { font-family: inherit; font-size: 14px; } #footable_parent_7873 thead { display: none; } #footable_parent_7873 a.nt_edit_link { display: none; } #footable_parent_7873 td { border-color: #fff; } #footable_parent_7873 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_7874 { font-family: inherit; font-size: 14px; } #footable_parent_7874 thead { display: none; } #footable_parent_7874 a.nt_edit_link { display: none; } #footable_parent_7874 td {

Guest: We bring on writer and researcher Dr. Aubrey de Grey to discuss his work on anti-aging. We talk with Dr. de Grey on his latest findings and his ultimate goal of eliminating aging so we call can one day celebrate our 1000th birthday. Resources and Links Sex-Specific Mechanisms of Stress Susceptibility – According to this article, stress-related mental illnesses are twice as prevalent in women as in men. Global Divergence of the Human Follicle Mite Demodex folliculorum: Persistent Associations between Host Ancestry and Mite Lineages – Researchers found that hosts with different regional ancestries harbor distinct lineages of mites and that these associations can persist despite generations spent in a new geographic region. Pain Produces Memory Gain – This article reveals that physical pain can make memories last longer. Integrated, Multi-Cohort Analysis Identifies Conserved Transcriptional Signatures across Multiple Respiratory Viruses – Researchers performed two integrated, multi-cohort analyses of publicly available transcriptional data of viral infections. Human Parasites in the Roman World – This article presents the archeological evidence for parasites in the Roman era in order to demonstrate the species present at that time, and highlight the health consequences for people living under Roman rule. Key Elements of Healthy Eating Patterns – This article provides guidelines and key recommendations for individuals to enhance eating and physical activity patterns. 9 Science-Backed Steps to Have the Best Sleep of Your Life – Tonight – This article shares nine simple, science-backed strategies you can do today that'll increase your odds of sleeping better tonight and waking up refreshed tomorrow. StemCells (STEM) Names New CEO – StemCells Inc. announced that Dr. Ian Massey, its President and Chief Operating Officer, has been appointed by the Board of Directors to succeed Martin McGlynn as the company’s Chief Executive Officer. A Protein Biomarker Confirms the Presence of Stem Cells that Maintain Ovaries – Stem cell activity in the outer lining of the ovary, now identified in mice by A*STAR researchers, will elucidate normal ovarian activity and offer insights into the origins of disease. Defined Three-Dimensional Microenvironments Boost Induction of Pluripotency – Researchers find that the physical cell confinement imposed by the 3D microenvironment boosts reprogramming through an accelerated mesenchymal-to-epithelial transition and increased epigenetic remodeling. Engineered Stem Cells May Help in ALS – Stem cells engineered to secrete neurotrophic growth factors may slow progression of amyotrophic lateral sclerosis (ALS). Slow Stem Cell Division May Cause Small Brains – Duke University researchers have figured out how a developmental disease called microcephaly produces a much smaller brain than normal: some cells are simply too slow as they proceed through the neuron production process. Genetically Engineering Self-Organization of Human Pluripotent Stem Cells into a Liver Bud-Like Tissue Using Gata6 – Scientists present a novel approach for generating and then co-differentiating human induced pluripotent stem cell-derived progenitors through a genetically engineered pulse of GATA-binding protein 6 (GATA6) expression. Photo Reference: Courtesy of Dr. Aubrey de Grey #footable_5807 { font-family: inherit; font-size: 14px; } #footable_parent_5807 thead { display: none; } #footable_parent_5807 a.nt_edit_link { display: none; } #footable_parent_5807 td { border-color: #fff; } #footable_parent_5807 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; }

Guest: Dr. David Mooney, Professor of Bioengineering at the Harvard School of Engineering and Applied Sciences discusses his work using biomaterials to help stem cells more efficiently integrate after transplantation. Resources and Links Gene-Editing Record Smashed in Pigs – Researchers modify more than 60 genes using CRISPR/Cas9 gene-editing technology in effort to enable organ transplants into humans. NASA Discovers Evidence for Liquid Water on Mars – NASA scientists have found compelling evidence that liquid water exists on Mars based on the “recurring slope lineae,” patches of precipitated salt that appear to dribble down Mars’ steep slopes like tears rolling gently down a cheek. Stem Cell Fraud: A 60 Minutes Investigation – Scott Pelley confronts one disgraced doctor offering false hope to a family with a disabled child using unproven stem cell treatment. Photo Reference: Courtesy of Dr. David Mooney #footable_5807 { font-family: inherit; font-size: 14px; } #footable_parent_5807 thead { display: none; } #footable_parent_5807 a.nt_edit_link { display: none; } #footable_parent_5807 td { border-color: #fff; } #footable_parent_5807 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_5808 { font-family: inherit; font-size: 14px; } thead { display: none; } #footable_parent_5808 a.nt_edit_link { display: none; } #footable_parent_5808 td { border-color: #fff; } #footable_parent_5808 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_7873 { font-family: inherit; font-size: 14px; } #footable_parent_7873 thead { display: none; } #footable_parent_7873 a.nt_edit_link { display: none; } #footable_parent_7873 td { border-color: #fff; } #footable_parent_7873 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_7874 { font-family: inherit; font-size: 14px; } #footable_parent_7874 thead { display: none; } #footable_parent_7874 a.nt_edit_link { display: none; } #footable_parent_7874 td { border-color: #fff; } #footable_parent_7874 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_5807 { font-family: inherit; font-size: 14px; } #footable_parent_5807 thead { display: none; } #footable_parent_5807 a.nt_edit_link { display: none; } #footable_parent_5807 td { border-color: #fff; } #footable_parent_5807 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_5808 { font-family: inherit; font-size: 14px; } thead { display: none; } #footable_parent_5808 a.nt_edit_link { display: none; } #footable_parent_5808 td { border-color: #fff; } #footable_parent_5808 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em;

Guest: Dr. Paul Knoepfler joins us to recap the STAP cell story in the light of the tragic death of Dr. Yoshiki Sasai. We also discuss a wide variety of topics related to publishing in science. Resources and Links Thousand-Strong Robot Swarm Throws Shapes, Slowly SAGE Publications Busts “Peer Review And Citation Ring,” 60 Papers Retracted Could a Dissolvable, Drug-Loaded Tampon Protect against HIV? Why Living in the Moment Is Impossible Our Brains Judge a Face’s Trustworthiness – Even When We Can’t See It Growing Human GI Cells May Lead to Personalized Treatments The Alzheimer's Cure That Worked on Mice Clues To Curbing Obesity Found in Neuronal ‘Sweet Spot’ Breast Cancer's BRCA1 and BRCA2 Not the Only Gene Mutations to Worry About: Who Should Care about PALB2 Stanford Scientists Create Remote-Controlled Nanoscale Protein Motors Stanford Bioengineering Team Builds Molecular Motors Pepper and Halt: Spicy Chemical May Inhibit Gut Tumors Study of Twins Discovers Gene Mutation Linked to Short Sleep Duration Deletion of the Mitochondrial Chaperone TRAP-1 Uncovers Global Reprogramming of Metabolic Networks Otzi Iceman Had Genetic Predisposition for Atherosclerosis: Much the Same in Ancient Peoples as It Is Today Potential 'Universal' Blood Test For Cancer Discovered Japanese Researcher, an Author of a Discredited Stem Cell Study, Is Dead Brigham Researcher in Flawed Stem Cell Study Will Step Down Transparency Promised for Vilified Impact Factor A Stem Cell Study Shows Promising Results for Severe Stroke Patients Stem Cell Research Gets Huge Boost from Australian Zebrafish Discovery Stem Cells Reveal How Illness-Linked Genetic Variation Affects Neurons A Simple And Efficient Method for Transfecting Mouse Embryonic Stem Cells Using Polyethylenimine Seamless Gene Correction of Beta-Thalassemia Mutations in Patient-Specific Cells Effect of Human Donor Cell Source on Differentiation and Function of Cardiac Induced Pluripotent Stem Cells Generation of Rat-Induced Pluripotent Stem Cells from a New Model of Metabolic Syndrome Photo Reference: Courtesy of Dr. Paul Knoepfler #footable_5807 { font-family: inherit; font-size: 14px; } #footable_parent_5807 thead { display: none; } #footable_parent_5807 a.nt_edit_link { display: none; } #footable_parent_5807 td { border-color: #fff; } #footable_parent_5807 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_5808 { font-family: inherit; font-size: 14px; } thead { display: none; } #footable_parent_5808 a.nt_edit_link { display: none; } #footable_parent_5808 td { border-color: #fff; } #footable_parent_5808 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_7873 { font-family: inherit; font-size: 14px; } #footable_parent_7873 thead { display: none; } #footable_parent_7873 a.nt_edit_link { display: none; } #footable_parent_7873 td { border-color: #fff; } #footable_parent_7873 img { margin-top: 0px; } .semantic_ui .ui.table { border: 0px solid !important; } .semantic_ui .ui.table td { padding: 0em; } #footable_7874 { font-family: inherit; font-size: 14px; } #footable_parent_7874 thead { display: none; } #footable_parent_7874 a.nt_edit_link { display: none; } #footable_parent_7874 td { border-color: #fff; } #footable_parent_7874 img { margin-top: 0px;

Guest:

Drs. Dina Radenkovic and Bruna Paulsen are Co-Founder & CEO and VP of Manufacturing and Therapeutic development at Gameto, a biotech company developing treatment solutions to improve women’s reproductive health. Their lead platform, Fertilo, uses ovarian support cells to mature oocytes outside of the body with the goal of making IVF and egg freezing shorter, safer, and more effective.

Featured Products and Resources:

• Learn more about organoid applications for studying human health with STEMCELL’s “Dynamic Modeling in Organoids” Wallchart.
• Generate functional fallopian tube organoids in 10 days with GyneCultTM.

The Stem Cell Science Round Up:

Sleep Speeds Healing – Immune cells that promote sleep are recruited to the brain after myocardial infarction.

Epigenetic Regulators of iPSC-T Cell Differentiation – CAR iPSC-T cells derived via G9a/GLP inhibition display enhanced antitumor activity.

Minimizing Off-Target Toxicity – Researchers identified carbonic anhydrase 12 as a druggable target for doxorubicin-induced cardiotoxicity.

Cell Division in Differentiation – Researchers have shown that cell state transitions are decoupled from cell division during early embryo development.

Images courtesy of Drs. Dina Radenkovic and Bruna Paulsen

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