Working Up ALKP Dominant Liver Conditions: Part 2 with Dr. Tristan Weinkle

Join us for Part 2 of the epic ALKP discussion! Today we conclude our discussion with Dr. Tristan Weinkle, DVM, DACVIM board certified in small animal internal medicine (SAIM), private practice clinician, and owner/founder of Sonant Veterinary Imaging and Education to talk about the mysteries of the liver, focusing on diseases that influence ALKP dominant enzymology.
Episode Resources and References:
Please visit our website for Dr. Weinkle's accompanying slides
Cortright CC, Center SA, Randolph JF, McDonough SP, Fecteau KA, Warner KL, Chiapella AM, Pierce RL, Graham AH, Wall LJ, Heidgerd JH, Degen MA, Lucia PA, Erb HN. Clinical features of progressive vacuolar hepatopathy in Scottish Terriers with and without hepatocellular carcinoma: 114 cases (1980-2013). J Am Vet Med Assoc. 2014 Oct 1;245(7):797-808. doi: 10.2460/javma.245.7.797. PMID: 25229531.
De Marco V, Noronha KSM, Casado TC, Nakandakare ER, Florio JC, Santos EZ, Gilor C.
Therapy of Canine Hyperlipidemia with Bezafibrate. J Vet Intern Med. 2017 May;31(3):717-722. doi: 10.1111/jvim.14701. Epub 2017 Apr 6. PMID: 28382723; PMCID: PMC5435059.
Griebie ER, David FH, Ober CP, Feeney DA, Anderson KL, Wuenschmann A, Jessen CR.
Evaluation of canine hepatic masses by use of triphasic computed tomography and B-mode, color flow, power, and pulsed-wave Doppler ultrasonography and correlation with histopathologic classification. Am J Vet Res. 2017 Nov;78(11):1273-1283. doi:
10.2460/ajvr.78.11.1273. PMID: 29076364.
Hall-Fonte DL, Center SA, McDonough SP, Peters-Kennedy J, Trotter TS, Lucy JM, Berger E, Byers C, Cummings CG, Burke E, Stegemen J, Pintar J, Kantrowitz L, Sharpe K, Weinkle T. Hepatocutaneous syndrome in Shih Tzus: 31 cases (1996-2014). J Am Vet Med Assoc. 2016 Apr 1;248(7):802-13. doi: 10.2460/javma.248.7.802. PMID: 27003022.
Kim C, Loftus JP, Huson HJ. Low alanine aminotransferase activity gene variant in a Siberian Husky with copper-associated hepatopathy. BMC Vet Res. 2023 Aug 7;19(1):111. doi: 10.1186/s12917-023-03681-6. PMID: 37550687; PMCID: PMC10405506. Miceli DD, Guevara JM, Ferraris S, Pignataro OP, Gallelli MF. Therapy for feline secondary hypertriglyceridemia with fenofibrate. J Feline Med Surg. 2022 Aug;24(8):e251-e257. doi: 10.1177/1098612X221104066. Epub 2022 Jun 17. PMID: 35713593.
Munro MJL, Hulsebosch SE, Marks SL, Gilor C. Efficacy of a micronized, nanocrystal
fenofibrate formulation in treatment of hyperlipidemia in dogs. J Vet Intern Med. 2021
Jul;35(4):1733-1742. doi: 10.1111/jvim.16190. Epub 2021 Jun 6. PMID: 34096101; PMCID: PMC8295657.
Sepesy LM, Center SA, Randolph JF, Warner KL, Erb HN. Vacuolar hepatopathy in dogs: 336 cases (1993-2005). J Am Vet Med Assoc. 2006 Jul 15;229(2):246-52. doi:
10.2460/javma.229.2.246. PMID: 16842046.
Steiner JM, Lainesse C, Noshiro Y, Domen Y, Sedlacek H, Bienhoff SE, Doucette KP, Bledsoe DL, Shikama H. Fuzapladib in a randomized controlled multicenter masked study in dogs with presumptive acute onset pancreatitis. J Vet Intern Med. 2023 Nov-Dec;37(6):2084-2092. doi: 10.1111/jvim.16897. Epub 2023 Oct 9. PMID: 37811705; PMCID: PMC10658511.
Xenoulis PG, Cammarata PJ, Walzem RL, Suchodolski JS, Steiner JM. Effect of a low-fat diet on serum triglyceride and cholesterol concentrations and lipoprotein profiles in Miniature Schnauzers with hypertriglyceridemia. J Vet Intern Med