PREVIEW Aliquot #43: Protein consumption: Finding the Balance

11/30/21 • 33 min

Protein is essential for maintaining muscle mass as we age. Modulating protein intake via dietary intake or fasting can have variable effects on aging and muscle growth. Whereas fasting turns off multiple pathways associated with aging, such as mTOR, IGF-1, growth hormone, and others, eating for optimal fitness activates these important processes. In this aliquot, we discuss:

(00:00) Introduction
(02:57) Growth-longevity trade-off (Mike Maser discussion)
(11:45) Role of IGF-1 in the aging process (Valter Longo discussion)
(12:55) mTOR and the IGF-1 regulation by amino acids (Peter Attia discussion)
(15:55) Anti-cancer effect of glutamine restriction outweigh the negative effect of glutamine deprivation on the gut and liver (Dominic D’Agostino discussion)
(22:45) The possibility of using selective nutrient restriction as an autophagy-inducer (Guido Kroemer discussion
(26:23) The IGF-1 Trade-Off: Performance vs. Longevity (Rhonda Patrick discussion)

You can see the original full interview with Dr. Kroemer You can see the original full interview with Dr. D'Agostino You can see the original full interview with Dr. Attia You can see the original full interview with Rhonda Patrick (with Mike Maser) You can see the original full interview with Dr. Longo You can see the video featuring Dr. Rhonda Patrick here

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Learn more and sign up at: https://www.foundmyfitness.com/aliquot

(00:00) Introduction
(02:57) Growth-longevity trade-off (Mike Maser discussion)
(11:45) Role of IGF-1 in the aging process (Valter Longo discussion)
(12:55) mTOR and the IGF-1 regulation by amino acids (Peter Attia discussion)
(15:55) Anti-cancer effect of glutamine restriction outweigh the negative effect of glutamine deprivation on the gut and liver (Dominic D’Agostino discussion)
(22:45) The possibility of using selective nutrient restriction as an autophagy-inducer (Guido Kroemer discussion
(26:23) The IGF-1 Trade-Off: Performance vs. Longevity (Rhonda Patrick discussion)

Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, biweekly Science Digest emails, and more.

Learn more and sign up at: https://www.foundmyfitness.com/aliquot

Previous Episode

PREVIEW Aliquot #41: Q&A and Interview Mashup - Blood Tests, Biomarkers, and Lab Work

“If you can not measure it, you can not improve it.” - William Thompson

Getting regular checkups and undergoing blood tests are fundamental to maintaining good health. FMF guests with expertise ranging from lipid metabolism to Alzheimer's disease risk to micronutrient status have shared their recommendations regarding blood tests that a person should consider adding to their yearly checkup. This Aliquot brings many of those conversations together in one place.

(00:00) Introduction
(02:44) Self-experimentation with the ketogenic diet and the biomarkers to measure daily (Tim Ferriss discussion)
(07:28) Longevity markers that are clinically available (Valter Longo discussion)
(14:55) Vitamin D and COVID-19 (Roger Seheult discussion)
(18:24) Getting a particle-focused lipid LDL panel performed requires a medical diagnosis and prescription (Ronald Krauss discussion)
(23:01) The MEND protocol and its successor, the ReCODE protocol for Alzheimer’s disease (Dale Bredesen discussion)
(35:24) How specific micronutrient inadequacies may promote immune dysregulation (Rhonda Patrick discussion)

You can see the original full interview with Tim Ferriss You can see the original full interview with Dr. Longo You can see the original full interview with Dr. Seheult You can see the original full interview with Dr. Krauss You can see the original full interview with Dr. Bredesen You can see the original full interview with Dr. Rhonda Patrick

Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, biweekly Science Digest emails, and more.

Learn more and sign up at: www.foundmyfitness.com/aliquot

Next Episode

PREVIEW Aliquot #51: What's the best omega-3 dosage for maximum benefit?

Early studies of omega-3 fatty acid intake demonstrated dramatic biological effects. Since then, the body of research enumerating the profound anti-inflammatory and multi-system, generalized health-promoting qualities of omega-3s continues to grow; however, some studies fail to show any effects from omega-3 supplementation. This source of consternation may, by and large, boil down to low doses, raising the question: what is the right dose of omega-3 to use? In this Aliquot, Dr. Bill Harris shares his experience administering some of the largest omega-3 doses ever used in human trials and gives his recommendations about optimal dosage taking genes and diet into account.

(00:00) Intro
(01:51) Tolerability of very high doses (25 grams or more)
(14:35) Why dose titration based on the RBC test is better than ball-parking
(15:58) The right dose for 95% of typical Westerner
(16:30) Why 4 grams might be better than 2 grams for some people
(20:00) How the FDA decided on dosage for prescription omega-3
(21:05) Does the omega-6 to omega-3 ratio matter?
(22:49) Concluding thoughts

Watch the full episode featuring Dr. Bill Harris

Get more Aliquots! Become a FMF Premium member and get full access to our members-only podcast, The Aliquot, plus live Q&As with Rhonda, biweekly Science Digest emails, and more.

Learn more and sign up at: https://www.foundmyfitness.com/aliquot