Personalized Medicine Podcast
Oleksandr Yagensky
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Top 10 Personalized Medicine Podcast Episodes
Goodpods has curated a list of the 10 best Personalized Medicine Podcast episodes, ranked by the number of listens and likes each episode have garnered from our listeners. If you are listening to Personalized Medicine Podcast for the first time, there's no better place to start than with one of these standout episodes. If you are a fan of the show, vote for your favorite Personalized Medicine Podcast episode by adding your comments to the episode page.
Ep#038: Unleashing the full power of CAR-T cells with Dr. Eric von Hofe
Personalized Medicine Podcast
02/23/22 • 34 min
Please welcome Dr. Eric von Hofe, the Senior Advisor and former President of Affyimmune Therapeutics. Eric’s story is a showcase of a remarkable career in the biotech industry. Eric studied Biology at UC Berkeley and received his PhD from the University of Southern California. HEric continued his career in cancer research doing two PostDocs at ETH Zurich and Harvard and then taking a position of Assistant Professor at the University of Massachusetts Medical School. In 1992 Eric made a transition to the biopharmaceutical industry leading the development of antisense oligonucleotide therapies at Hybridon. Eric subsequently led multidisciplinary drug development programs at Millennium Pharmaceuticals as a Director of Drug Discovery Research. Eric has been fundamental for two prominent immuno-oncology companies: Antigen Express, a company focusing on peptide-based cancer vaccines; and Affyimmune Therapeutics, a biotech startup developing novel approaches for CAR-T cell based therapies. With about 50 articles in peer-reviewed journals and four patents Eric is a true expert in the field of oncology
Together with Eric we discussed:
Differences between career in academia and industry
Evolution of therapeutic landscape in oncology over the last 30 years
Role of immunology in development of novel cancer therapies
CAR-T cells and their role in combating cancer
Affinity tuning of CAR-T cells as mechanism to decrease off-target effect
Cancer vaccines: peptide vs mRNA
The future of immunooncology
Get in touch with Eric:
LinkedIn: https://www.linkedin.com/in/ericvonhofe/
Email: [email protected]
Web: https://affyimmune.com/
Make sure to download the full show notes with our guest's bio, links to their most notable work, and our recommendations for further reads on the topic of the episode at pmedcast.com
Ep#021: Treating Parkinson's Disease Using Patient's Own Stem Cells with Professor Jeanne Loring
Personalized Medicine Podcast
01/13/21 • 53 min
In this episode, we dive deep into the world of stem cells with one of the most influential scientists in the field, Professor Jeanne Loring. Jeanne is a Professor Emeritus and a Director of the Center for Regenerative Medicine at Scripps Research. She made pivotal contributions to the field of stem cell research publishing 120+ papers on the topic. Jeanne is also a true veteran of the biotech industry working for some of the most important companies in the domain of stem cell therapeutics. Jeanne’s most recent venture is Aspen Neuroscience, a pharmaceutical company that develops cell replacement therapies for Parkinson’s disease based on a patient’s own induced pluripotent stem cells (iPSCs).
This episode is full of inspirational moments from Jeanne as she shares her experiences differentiating her own cells into beating cardiomyocytes and witnessing the delivery of organoids prepared in her lab to the International Space Station.
Together with Jeanne we discussed:
° Application of iPSCs in the treatment of Parkinson’s disease
° The founding story of Aspen Neuroscience
° Unexpected cost advantage of autologous vs allogeneic iPSCs
° Delivery systems for stem cell therapies
° Use of next-generation sequencing in quality control of stem cell therapies
° Logistics challenges in making iPSC-based therapies available
° Growing organoids at the International Space Station
° Future applications of iPSCs in drug screening and cell-replacement therapies
Make sure to listen until the very end of the episode, when Jeanne shares some very practical advice for aspiring young scientists.
Get in touch with Jeanne:
° LinkedIn: Jeanne Loring
° Twitter: @jeannefrances, @AspenNeuro
° Web: https://www.aspenneuroscience.com/
Make sure to download the full show notes with our guest's bio, links to their most notable work, and our recommendations for further reads on the topic of the episode at pmedcast.com
Ep#009: Cell-free DNA as a Precise Diagnostic Marker of Infectious Diseases with Dr. Tim Blauwkamp
Personalized Medicine Podcast
04/08/20 • 52 min
Tim did his PhD in Biochemistry at the University of Michigan, where he studied genes involved in nitrogen assimilation in bacteria. He then continued as a PostDoc first in Michigan and then at Stanford researching the mechanisms behind WNT signaling and its role in cell differentiation. He then joined Moleculo as a Head of Molecular biology. Moleculo was acquired by Illumina and Tim was responsible for bringing to life the technologies that made it possible to generate long and accurate sequencing reads. About six years ago, Tim co-founded Karius together with Mickey Kertesz. Tim and his team have achieved enormous progress during the last years, bringing the diagnostic tests to clinics that are already changing the lives of patients.
Together with Tim, we have talked about::
◦ The story behind Karius
◦ Cell-free DNA (cfDNA) as a blood biomarker of infection
◦ Why DNA sequencing has an edge over classical microbiology methods
◦ The challenge of isolating microbial cfDNA from blood
◦ Untangling cfDNA sequencing data with AI
◦ Why Coronavirus (SARS-CoV-2) is hard to detect using NGS
◦ Diagnosing sepsis based on microbial cfDNA
◦ Clinical evidence as a key to healthcare innovation
◦ Working with payers to spread the use of innovative diagnostic tests
◦ How cfDNA screening can become a cornerstone of next-generation medicine
Get in touch with Tim:
◦ LinkedIn: Tim Blauwkamp
◦ Twitter: @timblauwkamp
◦ Web (Karius): http://kariusdx.com/
◦ Email: [email protected]
Make sure to download the full show notes with our guest's bio, links to their most notable work and our recommendations for further reads on the topic of the episode at pmedcast.com
Ep#027: Finding the Best Possible Treatment for Each Cancer Patient with Dr. Dan Rhodes
Personalized Medicine Podcast
06/15/21 • 48 min
◦ Tune into this episode to learn more about:
◦ Dan’s journey from a PhD student to a serial biotech entrepreneur
◦ Differences between working in a small start-up vs large organizations
◦ Strata’s mission to determine best possible treatment for each cancer patient
◦ Role of RNAseq in precision oncology
◦ Approaches for highly-sensitive NGS of solid tumors
◦ Paradigm shift in clinical trials for personalized therapeutics
◦ Reimbursement landscape in cancer genomics
◦ Potential of asymptomatic NGS screening in oncology
◦ Dan’s vision for the future of precision oncology
Make sure to download the full show notes with our guest's bio, links to their most notable work, and our recommendations for further reads on the topic of the episode at pmedcast.com
Ep#45: Applying DNA Nanostructures to Personalized Medicine with Dr. Ali Aghebat Rafat
Personalized Medicine Podcast
07/27/22 • 38 min
Welcome to the next episode of the Personalized Medicine Podcast. In this episode, our host Aradhana sat down for a conversation with Dr Ali Aghebat Rafat, Scientist at Tilibit Nanosystems. Aradhana and Ali discussed DNA nanostructures, DNA self-assembly, barcoding, biochips and their potential applications in Personalized Medicine.
Tune in to this episode to learn more about:
◦ Tilibit Nanosystems and their mission
◦ Application areas of DNA origami in diagnostics
◦ What is DNA Paint
◦ A day in a life of a start-up scientist
◦ Role of nucleic acid nanostructures in Personalized Medicine
◦ The outlook on the future of DNA origami technology
Ep#042: Applying Epigenetics to Personalized Skincare with Dr. Shakiba Kaveh and Dr. Cristiana Banila
Personalized Medicine Podcast
05/18/22 • 32 min
Pharmaceutical and personal care companies have been trying to unlock personalized skincare for decades. Shakiba and Cristiana bring a special key to the table, and it is epigenetics.
Tune in into our interview to learn more about:
◦ The founding story of Mitra Bio
◦ The role of genetic and epigenetic factors in skin health
◦ Cracking epigenetic code
◦ Role of reliable models in understanding skin diseases
◦ Skin aging and personalized approaches to reverse it
◦ The future of personalized skincare
◦ Advice to young biotech entrepreneurs from Shakiba and Cristiana
Ep#044: Applying Nanoparticles and Microfluidics to Personalized Medicine with Martin Rabel
Personalized Medicine Podcast
06/29/22 • 48 min
Tune in to this episode to learn more about:
◦ Precision Nanosystems and their mission
◦ Role of nanoparticles and microfluidics in Personalized Medicine
◦ Next-Gen microfluidics technologies
◦ Application of nanoparticles in pharmaceutical applications
◦ Challenges in developing RNA-based lipid nanoparticles
◦ Role of regulatory bodies in implementation of personalized medicine approaches
◦ The outlook on the future of personalized medicine
Get in touch with Martin:
◦ LinkedIn: Martin Rabel
◦ Twitter: @rabel_martin
Ep#043: Developing Precision Medicines Using Cryo-EM with Dr. Sriram Subramaniam
Personalized Medicine Podcast
06/16/22 • 43 min
Tune into our interview with Sriram to learn more about:
◦ The founding story of Gandeeva Therapeutics
◦ The evolution of Cryo-EM technology
◦ Application of Cryo-EM in drug discovery
◦ Advantages of Cryo-EM over crystallography im mapping protein structures
◦ Making sense of experimental data with AI and machine learning
◦ The future of personalized medicine and role of structural biology in it
◦ Sriram’s advice for budding life science entrepreneurs
Ep#040: Eliminating Cancer Using Invariant Natural Killer T Cells (iNKTs) with Dr. Jennifer Buell
Personalized Medicine Podcast
04/07/22 • 53 min
Our guest today is Dr. Jennifer Buell, the founder, CEO and President of MiNK Therapeutics and the former President and COO of Agenus. Jennifer has over 25 years of experience in the biopharmaceutical space, having held multiple leadership positions at biotech companies. In her tenure at Agenus, she transformed a neoantigen vaccine development startup into a multifaceted company with a strong global footing. She is now leading MiNK therapeutics, the precision oncology company that develops targeted iNKT cells for treatment of various types of cancer and autoimmune diseases.
Together with Jennifer we discussed:
◦ Evolution of immunooncology over the the last two decades
◦ Role of immune system in fighting cancer
◦ Neoantigen vaccines as a tool for personalized cancer treatment
◦ Invariant Natural Killer T Cells (iNKTs) and their role in combating cancer
◦ Advantage of iNKTs over other cancer treatments
◦ Potential of combination therapies in oncology
◦ Challenges in bringing novel cell-based therapies to the market
◦ Advice to budding biotech entrepreneurs
◦ The outlook on the next decade of cancer treatment
Get in touch with Jennifer:
LinkedIn: Jennifer S. Buell
Twitter: @jbuell01
Web: https://minktherapeutics.com/
Special Episode: Ukraine
Personalized Medicine Podcast
03/08/22 • 5 min
Out team has prepared a list of trusted organizations and charitable foundations supporting Ukraine at the moment:
Support Ukrainian military (Official Bank Account of Ukrainian Ministry of Defense): https://bit.ly/35Kl4Gy
Humanitarian aid organizations providing aid for Ukrainians affected by war:
◦ Ukraine Humanitarian Fund managed by United Nations https://crisisrelief.un.org/t/ukraine - The Ukraine Humanitarian Fund is one of the UN's country-based pooled funds. Contributions are collected into a single, unearmarked fund and managed locally under UN leadership. As crises evolve, funds are made directly and immediately available to a wide range of partner organizations at the front lines of response. This way, funding reaches the people most in need when they need it
◦ Voices of Children - https://voices.org.ua/en/ - Charitable Foundation Voices of Children helps children affected by the war in (eastern) Ukraine. They provide psychological and psychosocial support to children. It helps them overcome the consequences of armed conflict
◦ Vostok-SOS - https://vostok-sos.org/en/ - Non-profit organization focused on comprehensive assistance to conflict-affected persons and IDPs, promoting democratic transformation and human rights values in Ukraine
If you would like to host a refugee, you can register at one of the following platforms:
◦ https://www.eu4ua.org/
◦ https://www.unterkunft-ukraine.de/
◦ https://www.ukraineshelter.com/en/
The global list of research groups and labs that are supporting Ukrainian scientists. Feel free to add your group or share this list with fellow Ukrainian scientists in need of help: https://docs.google.com/spreadsheets/d/1HqTKukfJGpmowQnSh4CoFn3T6HXcNS1T1pK-Xx9CknQ/edit?usp=sharing
Thank you very much for your support! You are awesome!
Stay safe
Peace
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FAQ
How many episodes does Personalized Medicine Podcast have?
Personalized Medicine Podcast currently has 48 episodes available.
What topics does Personalized Medicine Podcast cover?
The podcast is about Health & Fitness, Genetics, Biotech, Entrepreneurship, Research, Startup, Medicine, Podcasts, Science, Dna and Healthcare.
What is the most popular episode on Personalized Medicine Podcast?
The episode title 'Ep#46: Improving Healthy Longevity via Transcription Factors with Dr. Victor Bustos' is the most popular.
What is the average episode length on Personalized Medicine Podcast?
The average episode length on Personalized Medicine Podcast is 41 minutes.
How often are episodes of Personalized Medicine Podcast released?
Episodes of Personalized Medicine Podcast are typically released every 20 days, 23 hours.
When was the first episode of Personalized Medicine Podcast?
The first episode of Personalized Medicine Podcast was released on Nov 18, 2019.
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