14 Dan “Grassroots” Goldman (MJToday), Bhangini, and the CBD Slingshot Effect

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05/19/19 • 95 min

This weeks cannabis bonanza features Greer Barnes (actor/comedian), the unapologetic farmer Randy Cameron Jr., Jahan Marcu, Ph.D, and special guest Dan “Grassroots” Goldman from the MJToday podcast. While our resident Clinical Social Worker is at the beach, she does call us to Check In!

Segments:

• The Check In - How are we doing?

• Our word of the day is: Bhangini

• Research Focus/High Science: 1975 The Effects of Cannabinoids in Man

• CannaBusting - Finding or Fiction We will test your knowledge of recent cannabis news and science

• Mind Munchies

PLEASE support us on patreon - for as little as $1 per episode: https://www.patreon.com/newhemptimes

WORD OF THE DAY:

Bhangini : an ancient sanskrit and hindi word for cannabis translating to "breaks three kinds of misery”.

HIGH SCIENCE/RESEARCH FINDINGS:

The article for today’s High Science, is a trip through the wayback machine to 1975 and covers a foundational study documenting the so-called "slingshot effect”, a term used to describe the effects of taking THC and CBD together, which has been described on social media and other anecdotal reports.

Science Article Title:

Interactions in Man of delta-9-tetrahydrocannabinol - Cannabinol and Cannabidiol

• When taken orally CBD can delay onset, increase duration and intensity of THC

• This occurs because CBD can block the liver metabolism of drugs

• The effect appears slight in this study

Source:https://www.ncbi.nlm.nih.gov/pubmed/1097148

More Notes on the 75’ study:

Oral doses of delta-9-tetrahydrocannabinol (THC) 20 mg, combined with placebo or with 40 mg doses of cannabinol (CBN) and cannabidiol (CBD), were given to volunteers. The combination of THC with CBN produced no detectable changes in the quality, intensity, or duration of the effects of THC alone. The THC-CBD combination tended to delay onset and prolong effects of THC, while making them somewhat more intense. Even this interactive effect was slight, providing no reason to abandon the current practice of basing doses of marihuana for clinical studies solely on THC content. At the very most, the presence of comparatively large amounts of CBD in combination with THC may have increased slightly its clinical effects. CBD has been reported to be a potent inhibitor of hydroxylating enzymes. Such an action could delay formation of the Il-hydroxymetabolite, one which is known to be somewhat more potent than the parent substance. This action might also delay formation of dihydroxymetabolites, which are generally assumed to be inactive. Thus, the clinically observed slower onset and longer duration of the THC-CBD combination might possibly be explained by this mechanism.

Link to recent post on the subject:https://merryjane.com/culture/can-you-get-high-from-too-much-cbd

CANNABUSTING: Finding or Fiction?

When you hear strange things about Marijuana...Who you gonna Call?! CANNABUSTERS!

To warm us up, let’s start simply, a news report stated that in all, 31,075 people are registered with the program. Fewer than half of registered Ohio medical marijuana patients buying product: marijuana news

https://www.cleveland.com/open/2019/05/fewer-than-half-of-registered-ohio-medical-marijuana-patients-buying-product-marijuana-news.html

This story is out of florida, the Grandmother (or great-grandmother) that was arrested for CBD oil at Disney World, detained again this week after returning to the park and got caught using a vape pen. After some very serious comments about how she was treated, She quipped to the media, appearing with her lawyer, in an interview, that “I thought that chipmunk was following me but I kept telling myself not to be so paranoid.”BUT WHAT IS TRUE...is that the Grandmother, Hester Burkhalter, is threatening to sue Disney and Orange county police of Florida, represented by Civil rights attorney Benjamin Crump. Charges were dropped, but she is suing over things like spending 12 hours in jail while waiting to post bail...

https://www.clickorlando.com/news/great-grandmother-to-file-lawsuit-after-being-detained-at-disney-for-cbd-oil

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“You stole my schedule 1 drug recipe!” THC and CB...

Segments:

• The Check In - How are we doing?

• Our word of the day is: Bhangini

• Research Focus/High Science: 1975 The Effects of Cannabinoids in Man

• CannaBusting - Finding or Fiction We will test your knowledge of recent cannabis news and science

• Mind Munchies

PLEASE support us on patreon - for as little as $1 per episode: https://www.patreon.com/newhemptimes

WORD OF THE DAY:

Bhangini : an ancient sanskrit and hindi word for cannabis translating to "breaks three kinds of misery”.

HIGH SCIENCE/RESEARCH FINDINGS:

Science Article Title:

Interactions in Man of delta-9-tetrahydrocannabinol - Cannabinol and Cannabidiol

• When taken orally CBD can delay onset, increase duration and intensity of THC

• This occurs because CBD can block the liver metabolism of drugs

• The effect appears slight in this study

Source:https://www.ncbi.nlm.nih.gov/pubmed/1097148

More Notes on the 75’ study:

Link to recent post on the subject:https://merryjane.com/culture/can-you-get-high-from-too-much-cbd

CANNABUSTING: Finding or Fiction?

When you hear strange things about Marijuana...Who you gonna Call?! CANNABUSTERS!

https://www.cleveland.com/open/2019/05/fewer-than-half-of-registered-ohio-medical-marijuana-patients-buying-product-marijuana-news.html

https://www.clickorlando.com/news/great-grandmother-to-file-lawsuit-after-being-detained-at-disney-for-cbd-oil

---

“You stole my schedule 1 drug recipe!” THC and CB...

Previous Episode

13 Drug Testing Horses, Cannabis and Exercise Research NHT Episode 13

Hello my fellow Hemp nuts! Are you ready for the cannabis bonanza?!

Welcome to the New Hemp Times show recorded at Gotham Studio, the sweetest smelling podcast studio in the world. Today’s episode features Jahan Marcu, Ph.D, the unapologetic farmer Randy Cameron Jr, and Greer Barnes AND our resident clinical social worker, Jan Roberts, LCSW, DSW.

We have a fun show for you today!

Segments:

The Check In
Our word of the day is: Shivbooty = Shiva’s plant
Segment: "No, THC does that"
Research Focus/High Science:

Given popular stereotypes that cannabis use is associated with a lack of motivation and, indeed, extreme sedentary behavior (c.f., “couch lock”), increased cannabis use could worsen the sedentary lifestyle epidemic that the US is currently facing. On the other hand, cannabis use is banned by the World Anti-Doping Agency because of its potential to improve sports performance, and numerous reports in the popular press suggest that endurance athletes utilize cannabis in their training. Such conflicting ideas about the relationship between cannabis use and physical activity necessitate further investigation into how cannabis use may affect factors associated with regular physical activity participation.

5. CannaBusting - Finding or Fiction We will test your knowledge of recent cannabis news and science

World’s Longest Serving Marijuana Prisoner Finally Freed

https://www.freedomleaf.com/marijuana-prisoner-antonio-bascaro-freed/

What TSA Would Do If You Got Caught With Marijuana

https://thefreshtoast.com/cannabis/what-tsa-would-do-if-you-got-caught-with-marijuana/

Grandmother arrested for having CBD oil at Disney checkpoint | WDBO 965

https://www.news965.com/news/local/grandmother-arrested-for-having-cbd-oil-disney-checkpoint/6fQ1YUZIHzFSI7bLs6sLuN/

MS patients taking cannabis were able to reduce intake of opioids and benzodiazepines

According to a retrospective chart review of 77 patients diagnosed with multiple sclerosis treatment with cannabis allowed one third to reduce the intake of other medications, including opioids. Scientists of Dent Neurologic Institute Amherst in New York, USA, published their study results In the Journal Neurology.

Subjective improvement endorsed by patients was extensive, with alleviation of pain (71%), spasticity (43%), and sleep (42%). In addition, 34% of patients were able to decrease or discontinue other medications including opioids, stimulants, and benzodiazepines. A low rate of discontinuation (14%) was observed, most frequently due to cost (36%) and lack of efficacy (36%).

McCormack K, Lewandowski e, Rainka M, Aladeen T, Westphal E, Mazhari A, Mechtler L. Multiple Sclerosis and Use of Medical Cannabis: A Retrospective Review Evaluating Symptom Outcomes. Neurology Apr 2019, 92 (15 Supplement) P5.2-106;

Open Cannabis Project Dissolves In Response to Controversy Over Ag-Science Company Phylos Bioscience’s Breeding Program

https://www.wweek.com/news/business/2019/05/06/open-cannabis-project-dissolves-in-response-to-controversy-over-ag-science-company-phylos-biosciences-breeding-program/

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Next Episode

15 Back from the Beach, CBD and Opioids, President Kennedy and Marijuana? - New Hemp Times Episode 14, May 22nd, 2019.

Hello my fellow Hemp nuts! Are you ready for the cannabis bonanza?!Today in the studio we have Dr. Jan Roberts, LCSW, The illustrious actor/comedian, performing and being creative every week in Manhattan - Greer Barnes! And thank you to Miles who is keeping our sounds and video running smoothly. The unapologetic farmer, oddly enough apologizes for not making it today. And of course, I’m cannabis researcher, Jahan Marcu!Segments:

The Check In - How are we doing?
Our word of the day is: gatra-bhanga - ancient sanskrit or hindi word meaning “body disintegrator.
Research Focus/High Science: CBD and Morphine-seeking behavior
CannaBusting Finding or Fiction We will test your knowledge of recent cannabis news and science
Listener Q&A
Mind Munchies

WORD OF THE DAY:

Gatra-bhanga ancient sanskrit or hindi word meaning “body disintegrator.

HIGH SCIENCE/RESEARCH FINDINGS: Thank you to Sarah Russo and Dan Goldman for both texting me about this article and bringing it to my attention.https://www.leafly.com/news/health/cbd-can-help-with-heroin-addiction-study-findsResearchers in NYC (Shout to Mount Sinai) teamed up with a team in Spain. Dr. Yasmin Hurd is one of the authors of the paper, she is a colleague of mine. I have hosted panels that she has been on. She’s one of the enlightened drug abuse researchers. And someone I am hoping to work with on some of the institutes work. The work was published in the journal of neuroscience this week.TAKE HOME MESSAGE: The study in rats, translated into its human potential could mean that after abstaining from opioid use for a time, CBD could prevent relapse. But may have no effect on first wave of opioid addiction, CBD may not prevent the development of addiction but may help break the cycle or relapse after abstinence.

Cannabis and its benefits remain controversial Reports exist showing THC can both help or hurt regarding opioid use

Little research exists on CBD’s effect on opioid or heroin use Rats were trained to self- administer heroin, they learned very quickly Rats

were trained using environment cues Rats were given CBD during different phases of drug abuse cycle drug addiction cycle involves maintenance, extinction, and relapse CBD has no effect on any part of opioid use during first part of experiment After two weeks off of heroin, rats were challenged in “treatment tank” CBD protected rats from seeking out morphine when placed back in the “treatment tank” The effect lasted two weeks- which is amazing

Ren, Y., Whittard, J., Higuera-Matas, A., Morris, C. V., & Hurd, Y. L. (2009). Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances. Journal of Neuroscience, 29(47), 14764–14769.http://doi.org/10.1523/JNEUROSCI.4291-09.2009CANNABUSTING: Finding or Fiction?When you hear strange things about Marijuana...Who you gonna Call?! CANNABUSTERS1.Newsweek reports arrests are up at LAX for flying with cannabis. https://www.newsweek.com/can-i-fly-marijuana-lax-california-laws-arrest-plane-air-travel-weed-14232932. Did you know JFK smoked pot in the white house?While in the white house he suffered from severe back pain and addison’s disease, some claim Kennedy used cannabis to treat his conditions but there is no supporting evidence for this myth. He was taking several medications to help him function.“On the evening of July 16, 1962, according to [Washington Post executive] Jim Truitt, Kennedy and Mary Meyer smoked marijuana together. ... The president smoked three of the six joints Mary brought to him. At first he felt no effects. ”According to Mr. Truitt, “They smoked three of the joints before he (J.F.K.) told her: ‘No more. Suppose the Russians did something now.'”The most widely referenced account of Kennedy’s supposed marijuana use was not primarily linked with his health or with medical treatment. Rather, it was an anecdotal account of JFK’s supposedly being introduced to recreational pot use by one of his mistresses that was published in the National Enquirer tabloid in 1976 and referenced in the 1984 book The Kennedys: An American Drama by Peter Collier and David Horowitz. That latter work drew the following criticism in the aforementioned New York Times lette...