Leaky Gut - Concept or Clinical Entity? A Lesson from Dr Eamonn Quigley
11/03/20 • 43 min
In this episode, Nathan had the honour of discussing intestinal permeability and ‘leaky gut’ with renowned gastroenterologist, Dr Eamonn Quigley. He is internationally known for his research on gastrointestinal motility disorders, neurogastroenterology and the gut microbiome and has published more than 800 peer-reviewed articles, reviews, editorials, book chapters and case reports. Quigley is past president of the American College of Gastroenterology and the World Gastroenterology Organisation. His current responsibilities include, but are not limited to, the David M. Underwood Chair of Medicine in Digestive Disorders, Head of Gastroenterology and Hepatology at Houston Methodist Hospital, and Professor of Medicine at both the Institute of Academic Medicine and Weill Cornwell Medical College.
*Highlights *
- Debunking the gut barrier (6:00)
- Evaluating tests to assess gut permeability (12:40)
- Does targeting paracellular permeability improve disease? (22:00)
- The role of the gut microbiome (29:20)
- Maintaining the gut barrier (33:10)
Useful links and resources: e.g:
Follow Metagenics on Instagram here -
https://www.instagram.com/metagenics_anz/
Or on Facebook - https://www.facebook.com/metagenics
Keep up withthe latest industry news and events by joining our private Practitioner Only Facebook Group - https://www.facebook.com/groups/MetagenicsAU
Article: Quigley EMM, 2016 – ‘Leaky gut - concept or clinical entity?’ - https://pubmed.ncbi.nlm.nih.gov/26760399/
Article: Camilleri M, 2019 – ‘Leaky gut: mechanisms, measurement and clinical implications in humans’ - https://pubmed.ncbi.nlm.nih.gov/31076401/
Article: Zuo L, Kuo WT, Turner JR - Tight Junctions as Targets and Effectors of Mucosal Immune Homeostasis - https://pubmed.ncbi.nlm.nih.gov/32304780/
In this episode, Nathan had the honour of discussing intestinal permeability and ‘leaky gut’ with renowned gastroenterologist, Dr Eamonn Quigley. He is internationally known for his research on gastrointestinal motility disorders, neurogastroenterology and the gut microbiome and has published more than 800 peer-reviewed articles, reviews, editorials, book chapters and case reports. Quigley is past president of the American College of Gastroenterology and the World Gastroenterology Organisation. His current responsibilities include, but are not limited to, the David M. Underwood Chair of Medicine in Digestive Disorders, Head of Gastroenterology and Hepatology at Houston Methodist Hospital, and Professor of Medicine at both the Institute of Academic Medicine and Weill Cornwell Medical College.
*Highlights *
- Debunking the gut barrier (6:00)
- Evaluating tests to assess gut permeability (12:40)
- Does targeting paracellular permeability improve disease? (22:00)
- The role of the gut microbiome (29:20)
- Maintaining the gut barrier (33:10)
Useful links and resources: e.g:
Follow Metagenics on Instagram here -
https://www.instagram.com/metagenics_anz/
Or on Facebook - https://www.facebook.com/metagenics
Keep up withthe latest industry news and events by joining our private Practitioner Only Facebook Group - https://www.facebook.com/groups/MetagenicsAU
Article: Quigley EMM, 2016 – ‘Leaky gut - concept or clinical entity?’ - https://pubmed.ncbi.nlm.nih.gov/26760399/
Article: Camilleri M, 2019 – ‘Leaky gut: mechanisms, measurement and clinical implications in humans’ - https://pubmed.ncbi.nlm.nih.gov/31076401/
Article: Zuo L, Kuo WT, Turner JR - Tight Junctions as Targets and Effectors of Mucosal Immune Homeostasis - https://pubmed.ncbi.nlm.nih.gov/32304780/
Previous Episode
New Insights into the Gut-Brain Axis with Scott Anderson
For anyone fascinated by the gut-brain connection, this episode is sure to pique your interest. Scott C Anderson is a scientist, science journalist and co-author of the book, The Psychobiotic Revolution. With great enthusiasm, he brings us up to speed on gut-brain axis centred research – from the relationship between gut health and depression, to the role psychobiotics and diet in the management of mental health conditions.
** Highlights **
- Origins of research on the gut-brain axis (5:20)
- Chronic inflammation at the root of mood disorders (11:00)
- Markers used to assess gut health (14:30)
- The role of the vagus nerve in gut-brain cross-talk (21:20)
- Does poor gut health cause depression? (23:40)
- The relationship between gut health and ASD (28:00)
- Drawing our focus to cognitive health (33:00)
- What role does the small intestine play in disease? (37:00)
- Exploring the use of psychobiotics (42:30)
- Therapies to keep an eye on (57:25)
Useful links and resources: e.g:
Book –The Psychobiotic Revolution: Mood, Food, and the New Science of the Gut-Brain Connection
Amazon link to purchase book - https://www.amazon.com.au/Psychobiotic-Revolution-Scott-C-Anderson/dp/142621846X
Website - http://psychobiotic-revolution.com/
Twitter - https://twitter.com/Psychobiotic
Psychology today link: https://www.psychologytoday.com/au/blog/mood-microbe
Next Episode
The Science of Longevity with Dr Tommy Wood
Dr Tommy Wood earned his medical degree at the University of Oxford, and subsequently completed PhD in physiology and neuroscience at the University of Oslo. Currently, he holds academic positions at the University of Washington and Institute for Human and Machine Cognition. One of Dr Wood’s research interests is developing easily-accessible methods with which to track human health, performance, and longevity. In this episode, Dr Wood shares a plethora of information regarding the science of longevity, including patterns in ageing, determining biological age, and importantly, whether specific ingredients can increase longevity.
*Highlights *
- The fascination with extending the lifespan (5:00)
- Looking to the Blue Zones (8:30)
- The biomarkers of ageing (15:50)
- Determining your biological age (21:00)
- Biological drivers of ageing (31:40)
- Diving into caloric restriction (38:00)
- Macronutrients for health and longevity (55:00)
- Ingredients to improve longevity (75:00)
Useful links and resources: e.g:
For more Metagenics follow us on Instagram https://www.instagram.com/metagenics_anz/
If you're a Healthcare Practitioner in Australia or New Zealand, join our private Facebook group https://www.facebook.com/groups/MetagenicsAU
Follow Dr Tommy Wood on Instagram here - https://www.instagram.com/drtommywood/
Genetic testing providers Tommy Wood mentions:
Elysium - https://www.elysiumhealth.com/en-us/index
Chronomics - https://www.chronomics.com/dna
Paper – Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science. 2017 Mar 24;355(6331):1312-1317. doi: 10.1126/science.aad8242. PMID: 28336669
Link: https://pubmed.ncbi.nlm.nih.gov/28336669/
Paper – Newman S. Supercentenarians and the oldest old are concentrated into regions with no birth certificates and short lifespans. 2019 Jul. doi: 10.1101/704080
If you like this episode you’ll love
Episode Comments
Generate a badge
Get a badge for your website that links back to this episode
<a href="https://goodpods.com/podcasts/metagenics-institute-podcast-521196/leaky-gut-concept-or-clinical-entity-a-lesson-from-dr-eamonn-quigley-67913534"> <img src="https://storage.googleapis.com/goodpods-images-bucket/badges/generic-badge-1.svg" alt="listen to leaky gut - concept or clinical entity? a lesson from dr eamonn quigley on goodpods" style="width: 225px" /> </a>
Copy