31 - Healing the Gut

06/03/21 • 31 min

Is Crohn's passed on from family members? Does diet have anything to do with it?

In the first installment of our Cedars-Sinai series, hosts Dr. Steven Taback and Bill Curtis are joined by Gastroenterologist Dr. Stephan Targan, where they discuss the ins and outs of IBD and Crohn's disease. Dr. Targan shares some key insight on symptoms and techniques used in the fight against this widespread disease that is thought to affect almost 3 million Americans. Dr. Targan also enlightens us on the efficacy of probiotics and whether gluten plays much of a roll in IBD.

In this dedicated series, we're showcasing the medical breakthroughs and innovations from one of the world's most preeminent hospitals: Cedars-Sinai. Cedars-Sinai is dedicated to improving the health of the community and the world by setting the standard of excellence in medical education, research, and clinical care.
Episode Timestamps:
2:20 What is Crohn's Disease?
3:23 Is there a definitive cause for IBD (inflammatory bowel disease)?
4:29 What are the techniques used to test for Crohn's Disease?
5:01 How do we treat Crohn's Disease?
5:50 How important is diet’s impact on IBD?
7:06 What is the efficacy of probiotics in general and in regards to IBD?
8:35 Does eating vegetarian ease symptoms of Crohn's Disease?
10:34 Targeted Therapeutic Selection? What is it and how is it used with IBD?
14:22 What is a TNF inhibitor?
16:23 Does family history play into getting IBD?
17:11 At what age can you develop IBD?
18:14 Is each case of IBD trial and error, or are there some already established practices?
19:55 Immunotherapy and IBD?
20:36 What is fibrosis?
21:35 Has COVID had any impact of IBD?
22:59 Whats the distribution of Crohn's Disease geographically?
24:23 What is the population of those infected with IBD?
25:50 Genetic mapping and Crohn's Disease?
26:23 Does the consumption of gluten have any relation to Crohn's Disease?
27:55 Dr. Targan shares his main focus moving forward in his research
29:24 What are the symptoms the general public should be aware of when it’s time to go see a doctor because of IBD?

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Learn More: Medicine, We’re Still Practicing

Hosted by: Dr. Steven Taback & Bill Curtis

Produced and Edited by: AJ Moseley

Sound Engineering by: Steve Reickeberg

Theme Music by: Celleste and Eric Dick

A CurtCo Media Production

See omnystudio.com/listener for privacy information.

Is Crohn's passed on from family members? Does diet have anything to do with it?

-----------------

Learn More: Medicine, We’re Still Practicing

Hosted by: Dr. Steven Taback & Bill Curtis

Produced and Edited by: AJ Moseley

Sound Engineering by: Steve Reickeberg

Theme Music by: Celleste and Eric Dick

A CurtCo Media Production

See omnystudio.com/listener for privacy information.

Previous Episode

30 - Killing Cancer with Mice

On this episode, Bill and Dr. Steve are joined by three members of the Certis Oncology team: CEO Peter Ellman, Dr. Arun Singh M.D., and Surgical Oncologist Dr. Fritz Eilber M.D.

Certis is an early stage biotech company with a focus on advancing translational oncology through the O-PDX technique. O-PDX standing for “patient derived xenografts” are models of cancer where the tissue or cells from a patient's tumor are implanted into an immunodeficient or humanized mouse. Certis acquires intimate knowledge about the biology, chemistry and evolution of individual cancers to empower patients, inform treatment strategies and advance the next generation of oncology therapeutics. We think you’ll be just as inspired by this episode as we are.
Episode Timestamps:
3:40 Why is treating cancer still such a mystery?
4:30 What is cancer?
5:24 What is the Certis Oncology all about?
6:54 Petri Dish vs Mouse Model
7:39 The novelty of using immunosuppressive mice
9:35 How does Certis scale this model to the whole world
10:57 Can you start your oncology treatment with the mouse method via Certis?
12:08 Do insurance companies play ball with mouse model research?
13:15 What should general surgeons outside of Certis be doing with biopsy specimens?
14:32 What is the turnaround time on the mouse model research?
16:27 What is the dynamic with Certis and an individuals specific oncologist?
21:33 Peter Ellman shares how Certis got started
26:00 Does a tumor that is implanted in a mouse have the same likelihood of traveling to other organs as it would in a human?
28:22 Can patients request having work done with Certis?
30:13 Where is Certis getting it’s funding from, and what is the future dynamic with insurance companies?
33:00 Can the model work for other diseases outside cancer?

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Learn More: Medicine, We’re Still Practicing

Hosted by: Dr. Steven Taback & Bill Curtis

Produced and Edited by: AJ Moseley

Sound Engineering by: Steve Reickeberg

Theme Music by: Celleste and Eric Dick

A CurtCo Media Production

See omnystudio.com/listener for privacy information.

Next Episode

32 - Shortness of Breath

In the second installment for our Cedars-Sinai series, hosts Dr. Steven Taback and Bill Curtis are joined by pulmonary and Critical Care Director Dr. Victor Tapson, where they discuss all things pulmonary embolism and hypertension related. Pulmonary hypertension is known as the silent killer because more often than not, you’re only diagnosed after it’s too late. The panel discuses some of the causes for pulmonary embolism, how COVID has played a role in the disease, as well as signs and symptoms for both patients and physicians to look out for when treating the pulmonary embolism and hypertension.
In this dedicated series, we're showcasing the medical breakthroughs & innovations from one of the world's most preeminent hospitals: Cedars-Sinai. Cedars-Sinai is dedicated to improving the health of the community and the world by setting the standard of excellence in medical education, research, and clinical care.

Episode Timestamps:

2:30 How has COVID played a role in blood clots?

3:53 Dealing with the social devastation of COVID as a physician.

5:36 Are blood clots in COVID patients different than those who get clots without COVID?

8:30 Does anti-inflammatory agents or immunotherapy have any effect on blood clots?

9:49 What got Dr. Tapson originally interested in studying Pulmonary Embolism?

10:58 Why do DBT and PE consistently get missed on diagnosis?

12:00 What are the best tests to diagnosis PE?

13:53 Young physicians and the conundrum of minimizing the amount of testing with a disease that’s diagnosis relies mostly on “suspicion.”

16:00 Minimizing CT scans because of the dye/contrast’s effects on kidneys.

17:53 How do blood thinners work?

22:07 Pulmonary hypertension vs. high blood pressure.