Dominic Denk | Pomegranates, cancer and immunity

Researchers in Germany have found that a compound found in pomegranates may play a key role in fighting cancer.

Human trials are needed to establish whether findings seen in mice and test tubes also apply to people, but early results look promising.

Let's dive into the detail.

Pomegranates and other foods, such as nuts, contain ellagitannins. We use them to produce Urolithin A (UA) which is important for the health of our mitochondria, the energy centers of cells. Scientists say it also improves the function of immune cells in their fight against cancer.

We don't all produce UA at the same rate, but a supplement exists, in a highly pure form, which is used to boost cellular energy and muscle strength. Could it also aid the body's natural defense against cancer?

Dr. Dominic Denk, a physician at Frankfurt University Hospital was part of the team that carried out the latest research with the Frankfurt Cancer Institute.
In this interview we cover:

• The complexities involved in researching and combatting different types of cancer
• The "generous" nature of cancer cells and what drives the disease's progression
• The role of UA and the importance of mitophagy - the renewal of mitochondria
• The different extents to which we produce UA and the impact of aging
• What drives cancer and how the body responds to the disease
• The impact of exposing the immune system to UA and its impact on cancerous cells
• The next step: Clinical trials with healthy people to assess the impact of UA, through supplementation, on T cells.
• The benefit of having already approved forms of UA supplementation to further the research
• Why "cure" is a dangerous word, especially when dealing with cancer
• A cautious approach to supplementation and the importance of tried and testing health interventions such as optimizing sleep and getting enough exercise.

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The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.