Live Long and Master Aging

If the coronavirus pandemic has reminded us of anything, it is that there is nothing more important than our health and wellbeing. Now that the vaccine is a reality for people in the UK - and the rest of the world soon - there is real hope that the disease will be brought under control during the first part of next year.
"People in robust good health are massively less vulnerable to bad outcomes during the pandemic and more vital in general," says Dr. David Katz, a physician and co-author of the new book, How to Eat. Highlighting the importance of lifestyles and nutritional interventions, to promote health and vitality, Dr Katz says, there is much to be done tackling the "neglected scourges” of modern living, as we move on from the pandemic.
A renowned public health commentator and prolific writer, Dr Katz serves on the Scientific Advisory Board of Amazentis, a Swiss life science company and co-producer of this LLAMA podcast episode. In this interview, with Peter Bowes, he analyzes the current state of Covid-19; the challenge of sorting fact from fiction; the prospect of “herd immunity” and life after the virus. He also delves into the infinitely fascinating world of the microbiome and nutritional products that promote enhanced muscle mass and function as we age.
Recorded: December 1st, 2020 | Read a transcript and show notes at the LLAMA podcast website.
This episode of the LLAMA podcast was brought to you in association with Amazentis, a Swiss life science company, which is pioneering cutting edge, clinically validated cellular nutrition, under its Timeline brand.

Topics covered in this interview include

• How a rambunctious kid chose a career in medicine and developed a passion for preventing chronic disease, and promoting health.
• Analyzing the lifestyle practices that determine our state of health.
• Drama over data and the Covid-19 pandemic.
• What does herd immunity mean?
• Pandemic fatigue, opening up society and phasing back to normalcy.
• The "acute case for chronic health" as we emerge from the pandemic.
• Mitochondrial health, the microbiome, pomegranates and urolithin A.
• Amazentis' nutritional product Mitopure and clinical trials suggesting a positive impact on physical stamina and endurance.
• Can rejuvenation of mitochondria mimic the health of the world's fittest communities?
• Sleep, diet and exercise.

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• Anurag Singh: Pomegranates, muscle mass and healthy aging

The Live Long and Master Aging podcast shares ideas but does not

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The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Researchers in Germany have found that a compound found in pomegranates may play a key role in fighting cancer.

Human trials are needed to establish whether findings seen in mice and test tubes also apply to people, but early results look promising.

Let's dive into the detail.

Pomegranates and other foods, such as nuts, contain ellagitannins. We use them to produce Urolithin A (UA) which is important for the health of our mitochondria, the energy centers of cells. Scientists say it also improves the function of immune cells in their fight against cancer.

We don't all produce UA at the same rate, but a supplement exists, in a highly pure form, which is used to boost cellular energy and muscle strength. Could it also aid the body's natural defense against cancer?

Dr. Dominic Denk, a physician at Frankfurt University Hospital was part of the team that carried out the latest research with the Frankfurt Cancer Institute.
In this interview we cover:

• The complexities involved in researching and combatting different types of cancer
• The "generous" nature of cancer cells and what drives the disease's progression
• The role of UA and the importance of mitophagy - the renewal of mitochondria
• The different extents to which we produce UA and the impact of aging
• What drives cancer and how the body responds to the disease
• The impact of exposing the immune system to UA and its impact on cancerous cells
• The next step: Clinical trials with healthy people to assess the impact of UA, through supplementation, on T cells.
• The benefit of having already approved forms of UA supplementation to further the research
• Why "cure" is a dangerous word, especially when dealing with cancer
• A cautious approach to supplementation and the importance of tried and testing health interventions such as optimizing sleep and getting enough exercise.

Support the show

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

The science of aging is so infinitely fascinating that Dr. Sandra Kaufmann decided to immerse herself in the field, as a hobby. A pediatric anesthesiologist from Florida, Dr. Kaufmann, is also an athlete who manages to fit swimming, running and rock climbing around her busy hospital schedule. Determined to enjoy physical activity for as long as possible, she decided to carry out an extensive review of the scientific literature, to better understand our bodies as we grow old. She focussed on the mechanisms of aging at a cellular level and set out to sort fact from fiction when it comes to the substances or interventions that might help us age more slowly. The result is, The Kaufmann Protocol: Why We Age and How to Stop It, a book in which she sets out seven key tenets to maintaining optimum health. In this LLAMA podcast conversation, with Peter Bowes, Dr Kaufmann explains everything from the importance of mitochondrial health and the maintenance of metabolic pathways, to her live and let live attitude towards eating a donut a day.

In this interview we cover:

• Setting the bar high to "overcome all aging"
• The most ornate out-of-control hobby anybody can have
• A light-bulb moment having off a cliff.
• Is it selfish to focus on the science of 'stopping' aging?
• Becoming a human guinea pig to try to figure out why cells age.
• Nurturing the seven protocols
• Debunking myths - or ideas behind grandma's remedies - about interventions to slow down the aging process
• Junk food, including a donut a day. Really?
• Being an exercise junkie
• Biohacking: striving to improve what we are, but is the term realistic?
• Feeling like a teenager at 52

This episode is brought to you in association with Clinique La Prairie, the award-winning spa-clinic - and pioneering health and wellness destination - nestled on the shores of Lake Geneva in Montreux, Switzerland. Combining preventative medicine with bespoke lifestyle and nutrition plans, Clinique La Prairie offers a holistic approach to living fuller, healthier and longer lives.
The Live Long and Master Aging podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Support the show

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Starting a fitness journey is one of the most challenging things we can do. There are obstacles, excuses and setbacks that many find overwhelming. Shebah Carfagna, a single mother of an autistic child, knew she had to be strong to confront the challenges she faced - not only for the sake of her son, but her own wellbeing. Pre-dawn workouts and a lifetime of learning led to a career in fitness, with movement at its core. The co-founder of Ageless Workout, a Miami-based health and wellness company, Shebah now empowers others to live their best lives.
This episode is brought to you in association with Clinique La Prairie with whom we share a common goal of helping people pursue a long healthspan. The pioneering health and wellness destination, nestled on the shores of Lake Geneva in Montreux, Switzerland, combines preventative medicine with bespoke lifestyle and nutrition plans, and offers a holistic approach to living fuller, healthier, and longer lives.
In this interview we cover:

• Defining an ageless mindset
• A 3:45am gym routine that grew into a career around fitness
• Why movement first, rather than exercise?
• Addressing the barriers and obstacles to a fitness regime
• Maintaining personal strength to care for others
• Teaching the Joy Principle
• The power of walking
• Catering for the 80% of people who're lost and can'th fathom exercise
• Changing the messaging around fitness to be more inclusive
• Applying the Richard Simmons principle towards exercise, to bring people together
• Ecotherapy to nurture mind, body and soul.
• Maintaining power, strength and purpose as we age.
• Defining a vision of the future for aging individuals in 2030

Support the show

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

The search for the Fountain of Youth has intrigued and challenged scientists for centuries. Now, longevity is a buzzword - a multi-billion dollar industry with myriad interventions that could help us live longer and better. But are we any closer to fully understanding what it takes to extend healthy lifespan or healthspan? Nicklas Brendborg is a biotechnology researcher and the author of Jellyfish Age Backwards: Nature's Secrets to Longevity. The Copenhagen-based PhD student explores, with a critical eye, some of the fundamental questions related to aging science and mankind's quest to push the boundaries of healthy living. In this LLAMA podcast, with Peter Bowes, Nicklas explains how some animals have already achieved immortality and why the mechanisms behind aging continue to challenge researchers.
This episode is brought to you in association with Clinique La Prairie with whom we share a common goal of helping people pursue a long healthspan. The pioneering health and wellness destination, nestled on the shores of Lake Geneva in Montreux, Switzerland, combines preventative medicine with bespoke lifestyle and nutrition plans, and offers a holistic approach to living fuller, healthier, and longer lives.
In this interview we cover:

• Defining the Fountain of Youth and what we mean by the aging process.
• A critical analysis of aging research and the science of longevity
• Do jellyfish really age backwards?
• The small animal advantage when it comes to living a long life
• The intriguing of people with Laron syndrome - why they appear able to avoid the killer diseases of old age
• The whole body factor and why mental health also plays a role in living a long life
• Calorie restriction and life extension in mice
• Time-restricted eating
• An appreciation of the pioneering researcher, Dr. Roy Walford
• Self-experimentation and understanding our own bodies

Support the show

The Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.