#086 How Micronutrients & Exercise Ameliorate Aging | Dr. Rhonda Patrick
03/06/24 • 56 min
2 Listeners
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In today's episode, I'm bringing you along to the American Academy of Anti-Aging Medicine's Longevityfest Conference, where I had the honor of presenting a keynote last December. We'll explore some foundational yet effective tactics to enhance longevity and prevent diseases. Additionally, we'll delve into more intensive lifestyle modifications that, despite their demands, offer significant longevity benefits.In this episode, I discuss:
- (00:00) Introduction
- (04:48) The importance of vitamin D
- (09:08) How vitamin D deficiency affects all-cause mortality risk
- (12:34) Optimal vitamin D levels & supplementation
- (14:20) Why magnesium deficiency impairs DNA damage repair
- (18:00) Dangers of inadequate omega-3 intake
- (20:17) The correct omega-3 index level
- (24:42) How to correct vitamin D, omega-3, & magnesium inadequacies
- (26:27) Vigorous exercise is the best longevity drug
- (28:00) How increasing VO2 max affects life expectancy
- (32:46) Protocols for increasing VO2 max
- (35:37) How to measure VO2 max
- (36:44) What it takes to reverse 20 years of heart aging
- (39:41) Blood pressure benefits of vigorous exercise
- (40:58) The BDNF brain benefits of vigorous exercise
- (44:08) How vigorous intensity exercise improves focus & attention
- (45:21) Exercise protocols for maximizing BDNF
- (46:23) Anti-cancer effects of vigorous exercise
- (48:40) The benefits of exercise snacks
Download the 9-Page "Cognitive Enhancement Blueprint"
Discover my premium podcast, The Aliquot
Join over 300,000 people and sign up for my newsletter
In today's episode, I'm bringing you along to the American Academy of Anti-Aging Medicine's Longevityfest Conference, where I had the honor of presenting a keynote last December. We'll explore some foundational yet effective tactics to enhance longevity and prevent diseases. Additionally, we'll delve into more intensive lifestyle modifications that, despite their demands, offer significant longevity benefits.In this episode, I discuss:
- (00:00) Introduction
- (04:48) The importance of vitamin D
- (09:08) How vitamin D deficiency affects all-cause mortality risk
- (12:34) Optimal vitamin D levels & supplementation
- (14:20) Why magnesium deficiency impairs DNA damage repair
- (18:00) Dangers of inadequate omega-3 intake
- (20:17) The correct omega-3 index level
- (24:42) How to correct vitamin D, omega-3, & magnesium inadequacies
- (26:27) Vigorous exercise is the best longevity drug
- (28:00) How increasing VO2 max affects life expectancy
- (32:46) Protocols for increasing VO2 max
- (35:37) How to measure VO2 max
- (36:44) What it takes to reverse 20 years of heart aging
- (39:41) Blood pressure benefits of vigorous exercise
- (40:58) The BDNF brain benefits of vigorous exercise
- (44:08) How vigorous intensity exercise improves focus & attention
- (45:21) Exercise protocols for maximizing BDNF
- (46:23) Anti-cancer effects of vigorous exercise
- (48:40) The benefits of exercise snacks
Previous Episode
#085 Dr. Peter Attia on Mastering Longevity – Insights on Cancer Prevention, Heart Disease, and Aging
Download the 9-Page "Cognitive Enhancement Blueprint"
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Show notes are available by clicking here
Peter Attia, MD is a highly respected expert in preventive medicine, focused on the crucial subject of longevity and cardiovascular health. He's also the author of the NY Times best selling book Outlive - which I highly recommend if you have not read it already. Peter's philosophy transcends the conventional goal of merely extending lifespan; it's about enriching the quality of every year, ensuring that each stage of life is lived with optimal health and vitality.
In this episode, we discuss:
- (00:00) Introduction
- (07:36) Defining cardiovascular disease
- (09:43) Coronary plaque and fatality risk
- (13:34) How ApoB predicts heart disease
- (21:34) Factors elevating ApoB
- (27:23) Does high ApoB cause cardiovascular disease
- (37:01) ApoB thresholds for ASCVD prevention
- (40:27) Dietary factors raising ApoB
- (49:33) Genetics of ApoB and LDL
- (53:24) Does low LDL increase cancer?
- (56:19) Cholesterol-lowering drugs
- (59:59) Statins, uses, and side effects
- (1:03:12) Are statins toxic to mitochondria?
- (1:09:56) Ubiquinol for statin-induced muscle soreness
- (1:11:09) How to train in zone 2
- (1:17:09) Statins and neurodegenerative disease risk
- (1:21:54) Cholesterol synthesis in the brain (desmosterol role)
- (1:25:58) Statin alternatives
- (1:36:49) Berberine for CVD Risk Reduction?
- (1:39:36) Muscle as a glucose sink
- (1:51:38) Hemoglobin A1C Levels and Mortality Data
- (1:55:35) 80/20 Zone 2/VO2 Max Training Protocol
- (2:02:12) Insights from VO2 max testing data
- (2:12:17) How obesity increases cancer risk
- (2:15:03) Cancer screening
- (2:40:32) Menopause – hormonal shifts and health effects
- (2:45:13) Hormone replacement therapy (HRT)
- (2:58:57) Perimenopause diagnosis with hormone levels
- (3:02:04) HRT's impact on dementia, cancer, and heart disease risk
- (3:07:42) Vitamin D
- (3:16:24) Testosterone replacement for women's sexual function
- (3:18:47) HRT safety 10 years post-menopause
- (3:23:05) Testosterone & TRT
- (3:32:33) Blood pressure
- (3:45:30) Peter's longevity optimization routines
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Next Episode
#087 The Science of Magnesium and Its Role in Aging and Disease | Dr. Rhonda Patrick
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In this solo episode, I'm taking an in-depth look at magnesium – a critical yet frequently underestimated mineral in our health. Magnesium stands tall among vital nutrients for its significant role in multiple aspects of human physiology. During this podcast, we'll delve into the widespread negative health effects caused by a lack of magnesium and discuss why increasing your magnesium intake might be key to achieving optimal health.
In this episode, I discuss:
- (00:00) Introduction
- (04:27) Why the effects of magnesium are far-reaching
- (06:47) Why athletes need at least 10-20% more magnesium than the RDA
- (10:54) Why magnesium deficiency & insufficiency are common
- (12:19) How to determine if you're getting enough magnesium
- (15:14) Magnesium supplements
- (18:17) Is magnesium threonate better at crossing the blood-brain barrier?
- (25:08) Why magnesium threonate shouldn't count toward your RDA goal
- (26:04) What magnesium supplement do I take?
- (26:36) The effect of stress on magnesium balance
- (30:15) Why the energy demands of workouts affect magnesium balance
- (32:56) Does magnesium supplementation improve sleep?
- (34:04) Why trials in the field of nutrition are often misleading
- (37:26) Does higher magnesium intake improve cognition?
- (39:07) Does magnesium have a role in preventing Alzheimer's disease?
- (42:09) The effect of creatine on the brain (and its relationship to magnesium)
- (42:42) Why magnesium may prevent excitotoxicity in the brain
- (43:32) Magnesium's potential for managing migraines
- (46:41) The role of magnesium in aging
- (47:39) Why magnesium deficiency impairs DNA repair
- (49:13) Magnesium's role in cancer prevention
- (51:14) Why magnesium is intertwined in genomic stability
- (54:04) Why we shouldn't disregard observational data in nutrition
- (54:52) How magnesium intake affects mortality risk and cancer
- (57:49) Magnesium in osteoporosis prevention
- (59:21) Why magnesium intake in early life affects bone accretion
- (1:01:06) The effect of magnesium on vitamin D metabolism
- (1:06:36) Does magnesium treat high blood pressure?
- (1:10:12) Does magnesium help manage muscle cramps?
- (1:12:41) Is transdermal absorption of magnesium effective?
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