Banting 100 years later, AI and retinopathy screening and diagnosis, stage 1 type 1 diabetes and islet autoimmunity, and more!

09/29/23 • 53 min

Remembering a critical breakthrough in diabetes research on a fateful night over 100 years ago, Anand E. Rajesh and Aaron Y. Lee on the incredible potential of artificial intelligence in screening for and diagnosing diabetic retinopathy, Brigitte I. Frohnert on stage 1 type 1 diabetes and multiple islet autoimmunity, and more!

Welcome to episode no. 11 (October 2023) of Diabetes Care “On Air”—a new and different way to bring the research published in Diabetes Care to life. Join co-hosts Alice Cheng, MD, FRCPC, and Michael Rickels, MD, MS, as they discuss the latest and greatest content in the October 2023 issue of Diabetes Care.

0:45: Alice kicks off the episode with a fun October fact about a critical breakthrough in diabetes research that occurred in 1920. This breakthrough came in the form of an idea in a dream of Sir Fredrick Banting in the early morning hours of Halloween that year, and this idea contributed greatly to the discovery and successful purification of insulin.

2:20: Alice interviews Anand E. Rajesh and Aaron Y. Lee, authors of “Artificial Intelligence and Diabetic Retinopathy: AI Framework, Prospective Studies, Head-to-head Validation, and Cost-effectiveness” This study is an editor-selected feature article appearing in the October 2023 issue and is openly accessible at https://doi.org/10.2337/dci23-0032.

22:54: Mike interviews Brigitte I. Frohnert, lead author of “Refining the Definition of Stage 1 Type 1 Diabetes: An Ontology-Driven Analysis of the Heterogeneity of Multiple Islet Autoimmunity.” This study is also an editor-selected feature article appearing in the October 2023 issue and is openly accessible at https://doi.org/10.2337/dc22-1960.

43:36: In the “Diabetes Care Rapid Exchange,” Alice and Mike wrap up the episode by reviewing several interesting articles in the October 2023 issue of Diabetes Care. Studies highlighted in this segment include:

Sacks et al. Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus. https://doi.org/10.2337/dci23-0036
Speksnijder et al. Effect of Postmenopausal Hormone Therapy on Glucose Regulation in Women With Type 1 or Type 2 Diabetes: A Systematic Review and Meta-analysis. https://doi.org/10.2337/dc23-0451
Ahmed et al. Genetic Evidence Strongly Supports Managing Weight and Blood Pressure in Addition to Glycemic Control in Preventing Vascular Complications in People With Type 2 Diabetes. https://doi.org/10.2337/dc23-0855
Wei et al. All-Cause Mortality and Cardiovascular and Microvascular Diseases in Latent Autoimmune Diabetes in Adults. https://doi.org/10.2337/dc23-0739
Osafehinti et al. Type 1 Diabetes Genetic Risk Score Differentiates Subgroups of Ketosis-Prone Diabetes. https://doi.org/10.2337/dc23-0622
Berg et al. A Skin Care Program to Prevent Skin Problems due to Diabetes Devices in Children and Adolescents: A Cluster-Controlled Intervention Study. https://doi.org/10.2337/dc23-0462

To learn more about Diabetes Care, please visit diabetesjournals.org/care. Interested in submitting cover art to the journal? Please visit https://diabetesjournals.org/care/pages/submit_a_cover_image.

Sacks et al. Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus. https://doi.org/10.2337/dci23-0036
Speksnijder et al. Effect of Postmenopausal Hormone Therapy on Glucose Regulation in Women With Type 1 or Type 2 Diabetes: A Systematic Review and Meta-analysis. https://doi.org/10.2337/dc23-0451
Ahmed et al. Genetic Evidence Strongly Supports Managing Weight and Blood Pressure in Addition to Glycemic Control in Preventing Vascular Complications in People With Type 2 Diabetes. https://doi.org/10.2337/dc23-0855
Wei et al. All-Cause Mortality and Cardiovascular and Microvascular Diseases in Latent Autoimmune Diabetes in Adults. https://doi.org/10.2337/dc23-0739
Osafehinti et al. Type 1 Diabetes Genetic Risk Score Differentiates Subgroups of Ketosis-Prone Diabetes. https://doi.org/10.2337/dc23-0622
Berg et al. A Skin Care Program to Prevent Skin Problems due to Diabetes Devices in Children and Adolescents: A Cluster-Controlled Intervention Study. https://doi.org/10.2337/dc23-0462

Previous Episode

Slowing diabetes progression, artificial sweeteners and type 2 diabetes risk, and more!

Announcement of an upcoming special episode of Diabetes Care “On Air” on diabetes and social determinants of health, Sandra C. Naamann and George L. Bakris on the pillars of therapy for slowing diabetes progression, Mathilde Touvier on artificial sweeteners and type 2 diabetes risk, and more!

Welcome to episode no. 10 (September 2023) of Diabetes Care “On Air”—a new and different way to bring the research published in Diabetes Care to life. Join co-hosts Alice Cheng, MD, FRCPC, and Michael Rickels, MD, MS, as they discuss the latest and greatest content in the September 2023 issue of Diabetes Care.

0:43: Alice announces a special episode of Diabetes Care “On Air,” to be released later in the month. This special episode will focus on this year’s Diabetes Care Symposium on the impact of social determinants of health for diabetes development and care. The episode will feature a panel discussion with the authors of the articles presented at the symposium.

1:15: Mike interviews Sandra C. Naaman and George L. Bakris, authors of “Diabetic Nephropathy: Update on Pillars of Therapy Slowing Progression.” This study is an editor-selected feature article appearing in the September 2023 issue and is openly accessible at https://doi.org/10.2337/dci23-0030.

30:30: Alice interviews Mathilde Touvier, senior author of “Artificial Sweeteners and Risk of Type 2 Diabetes in the Prospective NutriNet-Santé Cohort.” This study is also an editor-selected feature article appearing in the September 2023 issue and is openly accessible at https://doi.org/10.2337/dc23-0206.

41:30: In the “Diabetes Care Rapid Exchange,” Alice and Mike wrap up the episode by reviewing several interesting articles in the September 2023 issue of Diabetes Care. Studies highlighted in this segment include:

Rafael Simó et al. Rapid Reduction of HbA1c and Early Worsening of Diabetic Retinopathy: A Real-World Population-Based Study in Subjects With Type 2 Diabetes. https://doi.org/10.2337/dc22-2521
Jose Garcia-Tirado et al. Assessment of Meal Anticipation for Improving Fully Automated Insulin Delivery in Adults With Type 1 Diabetes. https://doi.org/10.2337/dc23-0119
Oliver Artz et al. Grading Fractures on Foot and Ankle X-rays and MRI Scans in the Active Charcot Foot in Diabetes: How Strong Is the Agreement Between Modalities? https://doi.org/10.2337/dc23-0220
Yaogan Luo et al. Diet-Related Lipidomic Signatures and Changed Type 2 Diabetes Risk in a Randomized Controlled Feeding Study With Mediterranean Diet and Traditional Chinese or Transitional Diets. https://doi.org/10.2337/dc23-0314
Rodolfo J. Galindo et al. A Randomized Controlled Trial Comparing the Efficacy and Safety of IDegLira Versus Basal-Bolus in Patients With Poorly Controlled Type 2 Diabetes and Very High HbA1c 39–15%: DUAL HIGH Trial. https://doi.org/10.2337/dc22-2426
Andrea Kalus et al. Evaluation of Insulin Pump Infusion Sites in Type 1 Diabetes: The DERMIS Study. https://doi.org/10.2337/dc23-0426

Next Episode

undefined - Happy World Diabetes Day to all, predicting cardiometabolic health in type 2 diabetes, drug effectiveness for individuals with diabetes and frailty, and more!

Happy World Diabetes Day to all, predicting cardiometabolic health in type 2 diabetes, drug effectiveness for individuals with diabetes and frailty, and more!

Welcome to episode no. 12 (November 2023) of Diabetes Care “On Air”—a new and different way to bring the research published in Diabetes Care to life. Join co-hosts Alice Cheng, MD, FRCPC, and Michael Rickels, MD, MS, as they discuss the latest and greatest content in the November 2023 issue of Diabetes Care.

1:43: Mike gets things started with a November fun fact about diabetes: World Diabetes Day is November 14th! The 14th of November was chosen because it is Sir Fredrick Banting’s birthday. More information on World Diabetes Day can be found at worlddiabetesday.org.

2:20: Mike interviews Naveed Sattar, lead author of “Prediction of Cardiometabolic Health Through Changes in Plasma Proteins With Intentional Weight Loss in the DiRECT and DIADEM-I Randomized Clinical Trials of Type 2 Diabetes Remission.” This study is an editor-selected feature article appearing in the November 2023 issue and is openly accessible at https://doi.org/10.2337/dc23-0602.

18:37: Alice interviews Alexander Kutz, lead author of “Comparative Cardiovascular Effectiveness and Safety of SGLT-2 Inhibitors, GLP-1 Receptor Agonists, and DPP-4 Inhibitors According to Frailty in Type 2 Diabetes.” This study is also an editor-selected feature article appearing in the November 2023 issue and is openly accessible at https://doi.org/10.2337/dc23-0671.

30:15: In the “Diabetes Care Rapid Exchange,” Alice and Mike wrap up the episode by reviewing several interesting articles in the November 2023 issue of Diabetes Care. Studies highlighted in this segment include:

Mizrak et al. Declining Incidence Rates of Distal Symmetric Polyneuropathy in People With Type 1 and Type 2 Diabetes in Denmark, With Indications of Distinct Patterns in Type 1 Diabetes. https://doi.org/10.2337/dc23-0312
Sathish et al. Effect of Conventional Lifestyle Interventions on Type 2 Diabetes Incidence by Glucose-Defined Prediabetes Phenotype: An Individual-Participant Data Meta-analysis of Randomized Controlled Trials. https://doi.org/10.2337/dc23-0696
Stougaard et al. Time Trends in the Incidence of Diabetic Ketoacidosis Leading to Hospital Admission Among Adults With Type 1 Diabetes—A Nationwide Danish Register Study. https://doi.org/10.2337/dc23-0475
Song et al. Point-of-Care Capillary Blood Ketone Measurements and the Prediction of Future Ketoacidosis Risk in Type 1 Diabetes. https://doi.org/10.2337/dc23-0840
Hernandez et al. Randomization to a Provided Higher-Complex-Carbohydrate Versus Conventional Diet in Gestational Diabetes Results in Similar Maternal 24-Hour Glycemia and Newborn Adiposity. https://doi.org/10.2337/dc23-0617
Boughton et al. Fully Closed-Loop Glucose Control Compared With Insulin Pump Therapy With Continuous Glucose Monitoring in Adults With Type 1 Diabetes and Suboptimal Glycemic Control: A Single-Center, Randomized, Crossover Study. https://doi.org/10.2337/dc23-0728
Llamosas-Falcón et al. The Relationship Between Alcohol Consumption, Body Mass Index and Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis. https://doi.org/10.2337/dc23-1015