Understanding the Biology of Alzheimer's Disease with Neuroscience

12/09/22 • 29 min

Recorded at the Dementia Research Charity #Chatathon 2022 - Adam Smith interviews Dr Mark Dallas, Associate Professor in Cellular Neuroscience at University of Reading and Dr Richard Lofthouse, Research Fellow at University of Aberdeen & TauRx.

Dr Mark Dallas - Our research looks at non neuronal cells and the role they play in both initiating and progressing dementia. In particular we are looking at the role of microglia in regulating the inflammatory status of the drive and revealing the balance between good and bad inflammation. This is explored in the lab using a range of techniques looking at the changes in cellular function under disease relevant conditions.

Dr Richard Lofthouse - I am working on Biomarkers for Alzheimer's disease. We are researching tau antibodies and their use in different combinations to determine the fragmentation profile of tau in health and disease.

The 2022 Dementia Research Charity Chatathon LIVE was held on Friday 2nd December - A non-stop 12.5 hours livestream hosted by Adam Smith interviewing 68 Dementia Researchers and Special Guests working across all areas of discovery to beat Alzheimer's disease and all forms of dementia. Raising money for research and providing insights into the latest research taking place across the UK and Worldwide.

This year we are raising money for four amazing charities who all fund research - Alzheimer's Research UK, Alzheimer's Society, Race Against Dementia and The Lewy Body Society.

For more information and to donate visit http://www.chatathon.uk

This year we are raising money for four amazing charities who all fund research - Alzheimer's Research UK, Alzheimer's Society, Race Against Dementia and The Lewy Body Society.

For more information and to donate visit http://www.chatathon.uk

Previous Episode

Dealing with Health Inequalities, and Helping after a Dementia Diagnosis

Recorded at the Dementia Research Charity #Chatathon 2022 - Adam Smith interviews Nathan Stephens, PhD Student & Unpaid Care Worker at University of Worcester, Dr Clarissa Giebel, Senior Research Fellow at University of Liverpool and Dr Kat Algar-Skaife, Postdoctoral Research Fellow at the Norwegian University of Science and Technology.

Nathan Stephens - I work on understanding social and economic value of scaling up community based dementia support - in a failed market place. Passionate about health equity and under and unpaid care as a justice/rights issue. I am also an unpaid care worker and working with institutions locally such as CCGs, LAs, Public Health on the Worcestershire Meeting Centres Programme.

Dr Clarissa Giebel - My research focuses on enabling people living with dementia to live well and independently at home for as long as possible, whilst addressing inequalities in accessing the right care. For this, I am working with a number of national and international collaborators, in the Netherlands, Colombia, Chile, Australia, Uganda, Poland, and UAE and have published over 90 papers in the field.

Dr Kat Algar-Skaife - Over the past twelve years, I have led and contributed to research around understanding and improving support; developing and evaluating psychosocial, physical activity, and creative interventions. I collaborate with organisations such as Age Cymru and local authorities to ensure that my research has a real-life impact outside of an academic setting. I currently lead the SENSE-Emotion project which aims to provide a deeper understanding of the experiences and emotional responses of people living with dementia engaging with SENSE-GARDEN, an immersive digital sensory room.

This year we are raising money for four amazing charities who all fund research - Alzheimer's Research UK, Alzheimer's Society, Race Against Dementia and The Lewy Body Society.

For more information and to donate visit http://www.chatathon.uk

Next Episode

Using Data and Omics to predict Dementia Risk & Progression

Recorded at the Dementia Research Charity #Chatathon 2022 - Adam Smith interviews Dr Cristina Legido-Quigley, Head of Systems Medicine, at King's College London, Dr Petra Proitsi, ARUK Senior Post-doctoral Research Fellow also from King's College London and Dr Maryam Shoai, Senior Research Fellow in Statistical Genetics at University College London.

Dr Cristina Legido-Quigley - We work with omics sciences, this is mapping thousands of molecules in the body with our technology and then with data science trying to see which are the most important and change in Alzheimer’s. The next step is replenishing these molecules if they are beneficial or monitoring them if they signal a problem or a inflammatory.

Dr Petra Proitsi - I leverage genetic and multi omics (particularly metabolomics) information to enhance early dementia prediction and to find prevention and intervention targets.

Dr Maryam Shoai - I work in the Faculty of Brain Sciences on genetic data to identify predictive models for both risk of disease and progression of disease! This work has previously included exploring Nanotechnology, Materials Chemistry and Statistical Genetics. I have an interest in Big Data, Genetics, and Statistical methods for identification of risk and progression variables in neurodegenerative disorders.

This year we are raising money for four amazing charities who all fund research - Alzheimer's Research UK, Alzheimer's Society, Race Against Dementia and The Lewy Body Society.

For more information and to donate visit http://www.chatathon.uk