Maximizing Brain Health and Longevity with Dr. Austin Perlmutter
01/29/25 • 82 min
Austin Perlmutter, M.D., is a board-certified internal medicine physician and New York Times bestselling author. He is an expert in brain health, neuroinflammation, immunometabolism, and neuroplasticity. He received his medical degree from the University of Miami and completed his internal medicine residency at Oregon Health and Science University in Portland, Oregon. His focus is in helping others to improve decision-making and quality of life. He is also interested in methods of understanding and reducing burnout in the medical field. He is the co-author of Brain Wash. He is the host of the podcast Get The STUCK Out, where he examines things that keep us stuck through open minded questions and conversations. In our conversation, Dr. Perlmutter and I examine various reasons that a person’s decision making can be biased by their biology in unhealthy ways, and what can be done about it. Practitioners who are facing clients who are noncompliant will benefit from listening to his explanation of the mechanisms of the connection between brain and systemic inflammation and the pathways that are involved in the blood-brain barrier, systemic immunity and the brain. We also explore common triggers and solutions of neuroinflammation, especially sleep deprivation, the effects of polyphenols in the context of immunometabolism, and the effects of smoke and air pollution, sedentary behavior, alcohol and sugar consumption on brain health. Dr. Perlmutter’s insights clearly highlight his passion for educating people about the reasons that lifestyle medicine not only matters, but is critical to brain health and longevity.
I’m your host, Evelyne Lambrecht, thank you for designing a well world with us.
Episode Resources:
Dr. Austin Perlmutter - https://www.austinperlmutter.com/
Design for Health Resources:
Designs for Health - https://www.designsforhealth.com/
Designs for Health Practitioner Exclusive Drug Nutrient Depletion and Interaction Checker - https://www.designsforhealth.com/drug-nutrient-interaction/
Visit the Designs for Health Research and Education Library which houses medical journals, protocols, webinars, and our blog.
https://www.designsforhealth.com/research-and-education/education
The Designs for Health Podcast is produced in partnership with Podfly Productions
Chapters:
00:00 Intro.
01:50 Dr. Perlmutter is passionate about the substantial preventions and improvements breakthroughs in preventive health.
4:34 Austin’s father Dr. David Perlmutter’s career influenced, but didn’t entirely dictate his writing and medical career path.
10:01 Is decision making based on psychology or biology? Dr. Perlmutter explains.
14:30 Sleep is the number one action that can positively or negatively impact brain function.
17:40 The mechanisms of the connection between brain and systemic inflammation.
23:02 Pathways that are involved in the blood-brain barrier, systemic immunity and the brain.
29:51 Common triggers and solutions of neuroinflammation, especially sleep deprivation.
36:06 Dedicated stress relief practices including meditation, movement, decreased screen time seeking professional health, and dietary changes.
42:20 The benefits of utilizing a continuous glucose monitor.
43:20 The effects of polyphenols in the context of immunometabolism.
51:30 Overt signals that alcohol consumption is creating a risk for brain health.
54:24 Sedentary behavior dramatically increases the risk for brain issues, these tactics will counter its effects.
58:10 Smoke and air pollutants as a driver of microglial activation and needed action steps.
1:10:45 Tactics for improving air quality in the home.
1:12:40 Top personal supplements, top health practices, and the muscle health priority that Dr. Perlmutter has changed his mind about.
Austin Perlmutter, M.D., is a board-certified internal medicine physician and New York Times bestselling author. He is an expert in brain health, neuroinflammation, immunometabolism, and neuroplasticity. He received his medical degree from the University of Miami and completed his internal medicine residency at Oregon Health and Science University in Portland, Oregon. His focus is in helping others to improve decision-making and quality of life. He is also interested in methods of understanding and reducing burnout in the medical field. He is the co-author of Brain Wash. He is the host of the podcast Get The STUCK Out, where he examines things that keep us stuck through open minded questions and conversations. In our conversation, Dr. Perlmutter and I examine various reasons that a person’s decision making can be biased by their biology in unhealthy ways, and what can be done about it. Practitioners who are facing clients who are noncompliant will benefit from listening to his explanation of the mechanisms of the connection between brain and systemic inflammation and the pathways that are involved in the blood-brain barrier, systemic immunity and the brain. We also explore common triggers and solutions of neuroinflammation, especially sleep deprivation, the effects of polyphenols in the context of immunometabolism, and the effects of smoke and air pollution, sedentary behavior, alcohol and sugar consumption on brain health. Dr. Perlmutter’s insights clearly highlight his passion for educating people about the reasons that lifestyle medicine not only matters, but is critical to brain health and longevity.
I’m your host, Evelyne Lambrecht, thank you for designing a well world with us.
Episode Resources:
Dr. Austin Perlmutter - https://www.austinperlmutter.com/
Design for Health Resources:
Designs for Health - https://www.designsforhealth.com/
Designs for Health Practitioner Exclusive Drug Nutrient Depletion and Interaction Checker - https://www.designsforhealth.com/drug-nutrient-interaction/
Visit the Designs for Health Research and Education Library which houses medical journals, protocols, webinars, and our blog.
https://www.designsforhealth.com/research-and-education/education
The Designs for Health Podcast is produced in partnership with Podfly Productions
Chapters:
00:00 Intro.
01:50 Dr. Perlmutter is passionate about the substantial preventions and improvements breakthroughs in preventive health.
4:34 Austin’s father Dr. David Perlmutter’s career influenced, but didn’t entirely dictate his writing and medical career path.
10:01 Is decision making based on psychology or biology? Dr. Perlmutter explains.
14:30 Sleep is the number one action that can positively or negatively impact brain function.
17:40 The mechanisms of the connection between brain and systemic inflammation.
23:02 Pathways that are involved in the blood-brain barrier, systemic immunity and the brain.
29:51 Common triggers and solutions of neuroinflammation, especially sleep deprivation.
36:06 Dedicated stress relief practices including meditation, movement, decreased screen time seeking professional health, and dietary changes.
42:20 The benefits of utilizing a continuous glucose monitor.
43:20 The effects of polyphenols in the context of immunometabolism.
51:30 Overt signals that alcohol consumption is creating a risk for brain health.
54:24 Sedentary behavior dramatically increases the risk for brain issues, these tactics will counter its effects.
58:10 Smoke and air pollutants as a driver of microglial activation and needed action steps.
1:10:45 Tactics for improving air quality in the home.
1:12:40 Top personal supplements, top health practices, and the muscle health priority that Dr. Perlmutter has changed his mind about.
Previous Episode
Optimizing Gut Health and Healing with Dr. Vince Pedre
Dr. Vincent Pedre, medical director of Pedre Integrative Health, is a board-certified internist and a Functional Medicine–certified practitioner in private practice in New York City. Dr. Pedre’s integrative medical approach combines both Western and Eastern traditions. He is a clinical instructor at the Mount Sinai School of Medicine, and is also certified in yoga and medical acupuncture. His holistic philosophy is patient-centered and focuses on uncovering the root causes of illness to create long-term wellness. He is also the founder of Dr. Pedre Wellness, which offers health-enhancing programs, content and lifestyle products, dietary supplements, and weight loss programs. In our conversation, Dr. Pedre and I explore the critical role of gut health in overall wellness, the personalized approach outlined in his books, and strategies for optimizing gut health. He underscores the critical intersection of gut health and a productive immune system, highlights the danger of claiming that one health plan will fix all gut problems, and shares the sequence of his personalized patient protocol. He also shares his approach to dosings for prebiotics and gut healing nutrients, and shares his enthusiasm for meeting patients wherever they are in their journey toward optimal gut health.
I’m your host, Evelyne Lambrecht, thank you for designing a well world with us.
Episode Resources:
Dr. Vincent Pedre - https://pedremd.com/
Happy Gut: The Cleansing Program to Help You Lose Weight, Gain Energy, and Eliminate Pain
Design for Health Resources:
Designs for Health - https://www.designsforhealth.com/
Designs for Health Practitioner Exclusive Drug Nutrient Depletion and Interaction Checker - https://www.designsforhealth.com/drug-nutrient-interaction/
Visit the Designs for Health Research and Education Library which houses medical journals, protocols, webinars, and our blog.
https://www.designsforhealth.com/research-and-education/education
Chapters:
00:00 Intro
01:40 Dr. Pedre is finding gratitude amidst the fires in California.
2:35 The power of a practitioner's ability to impact on a patient’s overall life and health.
06:55 Dr. Pedre’s journey with gut healing began in childhood and shaped his career.
10:35 The critical intersection of gut health and a productive immune system.
14:28 Dr. Pedre’s books were inspired by his becoming an accidental gut expert.
19:48 The danger of claiming that one health plan will fix all gut problems.
24:04 Recommended Vagus nerve techniques including breathing and humming to counter depression.
28:16 The sequence of Dr. Pedre’s patient protocol starts with a thorough interview and a personalized diet protocol.
33:54 Dosings for prebiotics, gut healing nutrients and serum bovine immunoglobulin.
37:48 Microplastics and the microhabits that are endangering gut health including K-cups and espresso machines.
45:27 Recommendations for minimizing exposures and increasing detox practices.
48:38 Emerging research and health trends surrounding gut health and the microbiome.
52:03 Top personal supplements, top health practices, and the stress-management priority that Dr. Pedre has changed his mind about.
Next Episode
The Intersection of Cardiovascular Health and Gut Wellness with Dr. Pedi Mirdamadi
Dr. Pedi Mirdamadi is a Licensed Naturopathic Doctor and Holistic Nutritionist specializing in Functional Medicine, practicing at Oasis Health and Medicine in San Diego. After earning his undergraduate degree from the University of Toronto, Dr. Pedi earned his Master of Science in Kinesiology at York University and became a Registered Holistic Nutritionist (RHN) at the Canadian School of Natural Nutrition. He graduated as a Naturopathic Doctor at Bastyr University California and has received training from leaders in functional medicine, the Institute of Functional Medicine and is an Institute of Functional Medicine Certified Practitioner. In our discussion, Dr. Pedi and I explore gut health, cardiometabolic health, and some business talk about his large social media following. He highlights common stress patterns that are negatively impacting digestive health, the connection between cardiovascular health and GI health, and tests, lab markers, and other considerations for Dr. Pedi’s personalized nutrition plans. He answers some of the questions he hears most frequently, including what makes a good diet, why people are sicker than ever, and the biggest overlooked issues in cardiovascular health. He also highlights the power of social media in educating the public and reaching millions of potential patients and clients daily.
I’m your host, Evelyne Lambrecht, thank you for designing a well world with us.
Episode Resources:
Dr. Pedi Mirdamadi - https://drpedinaturalhealth.com/about/
Design for Health Resources:
Designs for Health - https://www.designsforhealth.com/
Designs for Health Practitioner Exclusive Drug Nutrient Depletion and Interaction Checker - https://www.designsforhealth.com/drug-nutrient-interaction/
Visit the Designs for Health Research and Education Library which houses medical journals, protocols, webinars, and our blog.
https://www.designsforhealth.com/research-and-education/education
The Designs for Health Podcast is produced in partnership with Podfly Productions.
Chapters:
00:00 Intro.
01:24 Rebuilding his health has been lighting Dr. Pedi up in the new year.
2:32 Pedi journey toward practicing functional medicine began as a personal trainer.
4:41 Common stress patterns that are negatively impacting digestive health.
5:46 Lab findings regularly show an increasing presence of H. pylori. Dr. Pedi offers natural treatment options.
9:27 People seem to be sicker than ever before. Is it caused by a weakened GI or weakened immune issues?
11:15 Dr. Pedi’s favorite gut health nutrients to target whole health and healing.
13:50 Applications for post biotics including addressing leaky gut.
14:30 The connection between cardiovascular health and GI health, and TMAO considerations.
19:20 What does a good diet include? The answer can be both personalized and generalized.
22:07 Lab markers and other considerations for Dr. Pedi’s personalized nutrition plans.
24:36 Addressing histamine intolerance and stabilizing mast cell response.
26:55 Dr. Pedi’s interactions with Dr. Mimi Guarneri greatly shaped his journey as a doctor.
33:15 Clinical patterns that are found in stool testing for the GI and cardiology connection.
34:05 Sleep apnea is one of the biggest overlooked issues in cardiovascular health.
40:43 The connection between oral health and cardiovascular health.
41:46 Supplement recommendations for increased cardiovascular health.
42:16 Dr. Pedi highlights all that social media has allowed naturopathic doctors to accomplish.
46:00 The power of consistently posting helpful marketing information on social media.
50:08 Key lessons learned in building a business.
52:25 Pedi’s personal favorite supplements, favorite health practices, and the approach to healing that he has changed his mind about in recent years.
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