Advancements in Evidence-Based Research and Nutraceutical Approaches to Managing Long Haul Syndrome with Dr. David Brady
08/02/23 • 62 min
This episode of Conversations for Health features Designs for Health, Inc. and Diagnostic Solutions Laboratory, LLC Chief Medical Officer, Dr. David Brady. With over 30 years of experience as an integrative practitioner and over 25 years in health sciences academia, Dr. Brady is a licensed naturopathic medical physician & clinical nutritionist, and professor and director emeritus of The Nutrition Institute at the University of Bridgeport.
In our conversation, Dr. Brady explores the rise and implications of long haul syndrome, or PASC, including popular correlation hypotheses, associations and patterns and insights from recent studies. He details the challenges of major gaps in long haul syndrome clinical care, patient stories, and developing nutraceutical and traditional treatment options that have proven effective, as well as his own case-by-case approach to helping patients manage long haul syndrome effectively as answers continue to be uncovered by researchers and medical professionals.
I’m your host Evelyne Lambrecht, thank you for designing a well world with us.
Key Takeaways:
[1:36] Dr. Brady highlights the defining symptoms of long haul syndrome.
[4:25] The prevalence of long haul syndrome in the U.S., according to a Brooking Institute study.
[5:18] Changes in our understanding of long haul syndrome from 2020 to the present.
[8:10] Addressing the major gaps in clinical care regarding long haul syndrome.
[10:33] Hypotheses regarding pathogenesis, mechanisms, and other fundamental long haul syndrome questions.
[13:02] The association between long haul syndrome, immunological cytokine patterns and other metabolomic signatures.
[19:24] Dr. Brady shares the resolution patterns and inconsistencies he has seen in panels.
[21:58] Possible correlations between genetic SNPs and the propensity toward developing long haul syndrome.
[24:43] Insights into the potential correlation between mitochondrial dysfunction and long haul syndrome.
[28:28] Findings from Harvard and Yale long haul molecular and metabolic function studies.
[30:49] Dr. Brady’s recommendations for addressing the vasculature aspect of long haul syndrome.
[33:06] Information gained from the microbiota patterns in long haulers.
[35:55] Dr. Brady details the journey of his wife from healthy, fit dancer to long hauler.
[40:30] Evidence based drugs and nutraceuticals that are being used to manage long haul syndrome.
[52:26] Dr. Brady’s approach to managing long haul symptoms on a case-by-case basis.
[54:51] Nutraceutical recommendations for approaching long haul syndrome and POTS.
[56:35] Dr. Brady shares his top three favorite supplements, his personal health practices, and what he has changed his mind about in recent years.
Episode Resources:
Presentation: (IHS) Long Covid | Exploring the Latest Science and Pathways Forward
Design for Health Resources:
Presentation: (CASI 22) David Brady – Clinical Round | COVID-19 Long Haul Syndrome
Blog: Specialized Pro-resolving Mediators Novel Mechanisms for Supporting a Healthy Inflammatory Response
Blog: Combination of Geranylgeraniol + Ubiquinol to Support Mitochondrial Function
Blog: Fueling Mitochondria for Illness Recovery
Blog: L-Carnitine for Energy Production and Beyond
Blog: Rhamnan Sulfate to Support the Endothelial Glycocalyx
Blog: How Polyphenols Promote a Healthy Gut Microbiome
Visit the Designs for Health Research and Education Library which houses medical journals, protocols, webinars and our blog.
This episode of Conversations for Health features Designs for Health, Inc. and Diagnostic Solutions Laboratory, LLC Chief Medical Officer, Dr. David Brady. With over 30 years of experience as an integrative practitioner and over 25 years in health sciences academia, Dr. Brady is a licensed naturopathic medical physician & clinical nutritionist, and professor and director emeritus of The Nutrition Institute at the University of Bridgeport.
In our conversation, Dr. Brady explores the rise and implications of long haul syndrome, or PASC, including popular correlation hypotheses, associations and patterns and insights from recent studies. He details the challenges of major gaps in long haul syndrome clinical care, patient stories, and developing nutraceutical and traditional treatment options that have proven effective, as well as his own case-by-case approach to helping patients manage long haul syndrome effectively as answers continue to be uncovered by researchers and medical professionals.
I’m your host Evelyne Lambrecht, thank you for designing a well world with us.
Key Takeaways:
[1:36] Dr. Brady highlights the defining symptoms of long haul syndrome.
[4:25] The prevalence of long haul syndrome in the U.S., according to a Brooking Institute study.
[5:18] Changes in our understanding of long haul syndrome from 2020 to the present.
[8:10] Addressing the major gaps in clinical care regarding long haul syndrome.
[10:33] Hypotheses regarding pathogenesis, mechanisms, and other fundamental long haul syndrome questions.
[13:02] The association between long haul syndrome, immunological cytokine patterns and other metabolomic signatures.
[19:24] Dr. Brady shares the resolution patterns and inconsistencies he has seen in panels.
[21:58] Possible correlations between genetic SNPs and the propensity toward developing long haul syndrome.
[24:43] Insights into the potential correlation between mitochondrial dysfunction and long haul syndrome.
[28:28] Findings from Harvard and Yale long haul molecular and metabolic function studies.
[30:49] Dr. Brady’s recommendations for addressing the vasculature aspect of long haul syndrome.
[33:06] Information gained from the microbiota patterns in long haulers.
[35:55] Dr. Brady details the journey of his wife from healthy, fit dancer to long hauler.
[40:30] Evidence based drugs and nutraceuticals that are being used to manage long haul syndrome.
[52:26] Dr. Brady’s approach to managing long haul symptoms on a case-by-case basis.
[54:51] Nutraceutical recommendations for approaching long haul syndrome and POTS.
[56:35] Dr. Brady shares his top three favorite supplements, his personal health practices, and what he has changed his mind about in recent years.
Episode Resources:
Presentation: (IHS) Long Covid | Exploring the Latest Science and Pathways Forward
Design for Health Resources:
Presentation: (CASI 22) David Brady – Clinical Round | COVID-19 Long Haul Syndrome
Blog: Specialized Pro-resolving Mediators Novel Mechanisms for Supporting a Healthy Inflammatory Response
Blog: Combination of Geranylgeraniol + Ubiquinol to Support Mitochondrial Function
Blog: Fueling Mitochondria for Illness Recovery
Blog: L-Carnitine for Energy Production and Beyond
Blog: Rhamnan Sulfate to Support the Endothelial Glycocalyx
Blog: How Polyphenols Promote a Healthy Gut Microbiome
Visit the Designs for Health Research and Education Library which houses medical journals, protocols, webinars and our blog.
Previous Episode
Optimizing Longevity and Health with Vitamin E Tocotrienols with Dr. Barrie Tan
This episode of Conversations for Health features Designs for Health Chief Science Officer Dr. Barrie Tan for a conversation about vitamin E tocotrienols, geranylgeraniol (GG) and research that has been conducted regarding these compounds. As a professor of Chemistry and Food Science and Nutrition at the University of Massachusetts, Dr. Barrie Tan is hailed as a trailblazer and the world’s foremost expert on vitamin E. Dr. Tan is credited with discovering a form of vitamin E called tocotrienol in the three major sources – Palm, Rice and Annatto. Described as a scientific pioneer, Dr. Tan is pursuing the simple mission of improving the everyday health of people’s lives through a tocotrienol product that is extracted from annatto and is the most potent form of vitamin E in existence today.
In our conversation, Dr. Tan highlights key differences between tocotrienols and tocopherols and offers insights into the cancer-prevention work that has shaped two decades of his life. He shares a high level overview of the benefits of tocotrienols, including several human clinical trials; the role of geranylgeraniol (GG); and offers simple ways to both explain and understand the function of these critical compounds in the journey toward longevity and health.
I’m your host Evelyne Lambrecht, thank you for designing a well world with us.
Key Takeaways:
[1:53] Dr. Barrie Tan recounts his serendipitous discovery of tocotrienols in the annatto plant.
[5:44] Key chemical and research-supported differences between tocotrienols and tocopherols.
[9:56] Benefits of tocotrienols including inflammation management and oxidative protection.
[13:43] Tactics for explaining the consistent benefits of tocotrienols to patients.
[14:58] An overview of the chronic condition human clinical trials conducted by Dr. Tan.
[17:40] Conditions and outcomes of non-alcoholic fatty liver disease studies.
[26:15] The science behind specific tocotrienol dosage recommendations.
[28:31] Dr. Tan highlights the impact of tocotrienol on genetic expression and why he rarely discusses it.
[33:09] The effective use of tocotrienols and tocopherols in skin health and hair growth.
[38:50] The ideal combination of supplements to support bone health and density.
[41:28] Dr. Tan’s discovery of GG, its location and functions in the body, and the mevalonic acid pathway.
[45:00] Three simple ways to identify the functions and purpose of GG.
[47:39] Why the body makes menaquinone-4 and the mechanism used to regulate it.
[53:25] Dr. Tan pieces together the relationship between bone health, MK-4, and GG.
[1:00:50] Dr. Tan shares his personal favorite supplements, his favorite health practices, and what he has changed his mind about after years in his field.
Episode Resources:
The Truth About Vitamin E: The Secret to Thriving with Annatto Tocotrienols
Design for Health Resources:
Blog: Vitamin E Tocotrienols, Metabolic Health, and Healthy Aging
Blog: Vitamin K2 and GG Mitigate Insulin Resistance by Improving Mitochondrial Function
Presentation: Dr. Barrie Tan at IHS 2023: Annatto’s Anti-Aging Benefits
Presentation: Dr. Barrie Tan at CASI 2022: Annatto Tocotrienol & Geranylgeraniol
Visit the Designs for Health Research and Education Library which houses medical journals, protocols, webinars and our blog.
Next Episode
A Conversation with Designs for Health Founder and CEO Jonathan Lizotte
This episode of Conversations for Health features Designs for Health Founder and CEO Jonathan Lizotte. With over 30 years of experience in the integrative medicine, medical foods, and nutritional supplement industry, Jonathan is an expert in the business of the therapeutic use of natural products. Under Jonathan’s leadership, DFH has become one of the fastest growing, most respected manufacturers and distributors of nutritional supplements nationwide.
In our conversation, Jonathan highlights the standards that make Designs for Health stand out in the saturated nutritional supplements market. We explore the DFH research standards, unique product features and quality approach to supplement trends that set Designs for Health apart from anything else available to consumers. Jonathan shares his journey with DFH and his inspiring outlook on the core benefits and future of nutritional supplements.
I’m your host Evelyn Lambrecht, thank you for designing a well world with us.
Key Takeaways:
[1:13] The inspiration and drive behind the founding of Designs for Health.
[3:45] Jonathan’s upbringing shaped his passion for whole health and wellbeing.
[4:25] Significant milestones that shaped Designs for Health into the company it is today.
[6:20] An overview of regulatory and product changes in the supplement industry.
[8:11] Key measures that address safety and regulatory concerns.
[11:24] Details about third party testing details and circumstances.
[13:22] Unique features and approaches that set Designs for Health at the top of the market.
[15:30] The Science-First research and development process for creating DFH products.
[19:06] Changing trends in supplement offerings and the industry as a whole.
[21:49] Jonathan’s top three favorite supplements and his personal health and nutrition practices.
[28:22] An overview of GG research and findings and why Jonathan recommends including it in every diet.
[30:35] The core nutrient concept that Jonathan has not changed his mind about in recent years.
Episode Resources:
DSHEA - Dietary Supplement Health and Education Act of 1994
PubMed: Calcium supplement: humanity's double-edged sword
PubMed: Folate, folic acid and 5-methyltetrahydrofolate are not the same thing
The Weston A. Price Foundation (WAPF)
Design for Health Resources:
The Designs For Health Philosophy
Designs For Health Quality and Manufacturing
Blog: Berberine’s Potential to Support Heart Health and Blood Sugar Metabolism
Blog: Intro to Geranylgeraniol
Blog: Vitamin E Tocotrienols, Metabolic Health, and Healthy Aging
Visit the Designs for Health Research and Education Library which houses medical journals, protocols, webinars and our blog.
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