Emerging Therapies for Pruritus in PBC

12/18/24 • 23 min

Clinical gaps in the treatment of pruritus in primary biliary cholangitis (PBC) remain. In this episode, taken from a recent symposium, Marlyn J. Mayo, MD; Stuart C. Gordon, MD; and Pam Rivard, RN, a person living with PBC, discuss emerging therapies currently in clinical trials for the management of this disease that can dramatically affect patients’ quality of life.

Listen as they discuss:

Gaps in current management
Patient perspectives: why we should not dismiss itching as an underlying psychologic problem
PPAR agonists and how they affect pruritus
BEZURSO and FITCH
ELATIVE
ENHANCE and RESPONSE
IBATs (inhibitors of bile acid transport)
GLIMMER
Common questions

Presenters:

Marlyn J. Mayo, MD
Professor of Internal Medicine
Division of Digestive & Liver Diseases
UT Southwestern Medical Center
Dallas, Texas

Stuart C. Gordon, MD
Professor of Medicine
Wayne State University School of Medicine
Director, Division of Hepatology
Henry Ford Health
Detroit, Michigan

Pam Rivard, RN
Person living with PBC

Link to full program:
https://bit.ly/3Dnfb2E

Listen as they discuss:

Gaps in current management
Patient perspectives: why we should not dismiss itching as an underlying psychologic problem
PPAR agonists and how they affect pruritus
BEZURSO and FITCH
ELATIVE
ENHANCE and RESPONSE
IBATs (inhibitors of bile acid transport)
GLIMMER
Common questions

Presenters:

Marlyn J. Mayo, MD
Professor of Internal Medicine
Division of Digestive & Liver Diseases
UT Southwestern Medical Center
Dallas, Texas

Stuart C. Gordon, MD
Professor of Medicine
Wayne State University School of Medicine
Director, Division of Hepatology
Henry Ford Health
Detroit, Michigan

Pam Rivard, RN
Person living with PBC

Link to full program:
https://bit.ly/3Dnfb2E

Previous Episode

Clinical Management of Pruritus in PBC

Although there is currently no FDA-approved treatment for pruritus in primary biliary cholangitis (PBC), symptoms can be mitigated with nonpharmacologic or pharmacologic agents. In this episode, Marlyn J. Mayo, MD; Stuart C. Gordon, MD; and Pam Rivard, RN, a person living with PBC, discuss the clinical management of pruritus in PBC, including:

Pruritus assessment tools
Optimal use of tools, including frequency of assessment
Current management of pruritus
Nonpharmacologic interventions
Pharmacologic agents
Strategies to optimize assessment and management of pruritus
Collaborative care
Development of a treatment plan
Ongoing assessment and adjustment of therapy
Resources and support for patients

Presenters:

Marlyn J. Mayo, MD
Professor of Internal Medicine
Division of Digestive & Liver Diseases
UT Southwestern Medical Center
Dallas, Texas

Stuart C. Gordon, MD
Professor of Medicine
Wayne State University School of Medicine
Director, Division of Hepatology
Henry Ford Health
Detroit, Michigan

Pam Rivard, RN
Person living with PBC

Link to full program:
https://bit.ly/3Dnfb2E

Next Episode

Key PBC Studies From AASLD 2024

In this episode, Sonal Kumar, MD, MPH, discusses key findings from primary biliary cholangitis (PBC) studies presented at AASLD 2024, including:

ELATIVE, a phase III trial of elafibranor for PBC
RESPONSE, a phase III trial of seladelpar for PBC
ASSURE, another phase III trial of seladelpar for PBC

Presenter:
Sonal Kumar, MD, MPH
Director, Clinical Gastroenterology and Hepatology
Assistant Professor of Medicine
Weill Cornell Medical College
New York, New York

Link to full program:
https://bit.ly/41tvSDu

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