
“The Painful Truth about Hunger in America” with Professor Mariana Chilton
11/17/24 • 59 min
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“The Network of Life: A New View of Evolution” with Professor David Mindell
For a long time, the prevailing perspective on evolution has been that it follows a vertical pathway, where genetic information is passed down from one generation to the next in a linear fashion, resembling a "tree of life." This classical view suggests that species evolve through a process of divergence from common ancestors, resulting in a branching tree structure that traces the lineage of life over time. In his new book “The Network of Life” Professor David Mindell emphasises the need to update this understanding, and explains that evolution functions more like a distributed, decentralised network. In this framework, there are possibilities for horizontal evolution, where genetic material is shared across species in a more fluid and interconnected manner. The book looks at the forces behind horizontal evolution, such as interbreeding, genetic recombination, merging of species, horizontal gene transfer, and coevolution. The network view of evolution leads to a new symbiotic theory of health. It suggests that the future well-being of humans, other species, and our environment relies on how life evolves and adapts within this interconnected web. In this episode of Bridging the Gaps I speak with Professor David Mindell. Professor David Mindel is a senior researcher of Zoology at the University of California, Berkeley. He is a former professor of ecology and evolutionary biology at the University of Michigan, director of the University of Michigan Museum of Zoology, and Dean of Science at the California Academy of Sciences. We begin our discussion by revisiting the traditional concept of vertical evolution, where life is represented as a branching tree. We explore how this classical framework explains the development of species over time and then shift to discussing two core ideas in evolutionary theory: natural selection and genetic mutation. For much of history, evolution has been viewed primarily through the lens of vertical inheritance. One reason for this focus on vertical evolution is that early evolutionary studies, including Darwin's, were centred around natural selection, with limited knowledge about genetic mutations. Today, we know they are essential drivers of evolution. We examine how this early gap in understanding may have shaped the preference for the vertical model of evolution. Next, we delve into the concept of horizontal evolution, and discuss the point made in the book that “horizontal evolution has been happening since life began on Earth”. To set the stage, I ask him to outline what we currently know about the origins of life. We also discuss the intriguing role of viruses. We then dive into the key discoveries and discuss processes such as hybridization, species merging, and horizontal gene transfer that provide strong evidence for this interconnected view of life. We discuss various contributions of prominent scientists and pivotal studies that have reshaped our understanding of evolution. Finally, we explore the exciting possibilities that arise from this new understanding. By embracing the network view of evolution, we can enhance research on synthetic life, support assisted evolution to help species adapt to climate change, and revolutionise our approaches to biotechnology, medicine, and environmental sustainability. This has been an insightful and enriching conversation, shedding light on the profound impact of horizontal evolution on our world. Complement this discussion with ““Zero to Birth: How the Human Brain Is Built” with Professor William Harris” available at: https://www.bridgingthegaps.ie/2022/10/zero-to-birth-how-the-human-brain-is-built-with-professor-william-harris/ And then listen to ““The Exquisite Machine: The New Science of the Heart” with Professor Sian Harding” available at: https://www.bridgingthegaps.ie/2022/12/the-exquisite-machine-the-new-science-of-the-heart-with-sian-harding/
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“The Evolution of Biological Information” with Professor Christoph Adami
Consider this thought-provoking statement: “Life is information that maintains itself.” This argument, proposed by Professor Christoph Adami in his book “The Evolution of Biological Information: How Evolution Creates Complexity, from Viruses to Brains” places information at the heart of biological systems. Adami's innovative perspective offers fresh insights into phenomena such as the evolution of drug resistance in viruses, the development of cellular communication, and the emergence of intelligence. By framing information as the unifying principle of biology, this approach provides a systematic way to explore the origin of life—both on Earth and beyond. In this episode of Bridging the Gaps I speak with Professor Christoph Adami. Christoph Adami is professor of microbiology and molecular genetics & physics as well as astronomy at Michigan State University. A pioneer in the application of methods from information theory to the study of evolution, he designed the Avida system that launched the use of digital life as a tool for investigating basic questions in evolutionary biology. He has received several awards, including the NASA Exceptional Achievement Medal and the Lifetime Achievement Award from the International Society for Artificial Life. We begin with an in-depth exploration of Shannon’s information theory, focusing particularly on the concept of entropy. This foundation sets the stage for a discussion on how biological systems store and preserve information. We delve into the information content of genes and proteins, highlighting a key idea from the book: “Living organisms know some very important facts about the world they inhabit and thrive in.” Next, we examine the concept of genetic information and its storage within DNA molecules and genomes. This includes a detailed look at the nature of this information and the latest understanding of the data encoded within the genome. We then turn to the core mechanisms—or laws—of evolution: inheritance, variation, and selection, framing these processes as the measurement, processing, and transmission of information. To describe evolution through the lens of information theory, Adami incorporates the concept of Maxwell’s demon, a thought experiment that challenges the second law of thermodynamics. We discuss this thought experiment in detail and its application to understanding the evolution of biological information. Finally, we explore the profound question of the origin of life, accompanied by an engaging discussion on viruses. Before finishing this discussion, we also touch upon the nature and challenges of multidisciplinary research. Overall, this has been an enlightening and highly informative journey into the intersection of biology and information theory. Complement this discussion with ““The Network of Life: A New View of Evolution” with Professor David Mindell” available at: https://www.bridgingthegaps.ie/2024/10/the-network-of-life-a-new-view-of-evolution-with-professor-david-mindell/ And then listen to ““Zero to Birth: How the Human Brain Is Built” with Professor William Harris” available at: https://www.bridgingthegaps.ie/2022/10/zero-to-birth-how-the-human-brain-is-built-with-professor-william-harris/
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