Episode 40 - On The Wards: The Antibodies of Wrath | IVIG and Rituximab Reactions

04/01/25 • 54 min

IVIG & Rituximab – both involve Antibodies – and both can lead to infusion reactions that you may be called to as a junior doctor. But where do these antibodies even come from? Why are we even giving these treatments? What are you meant to do when called to review the patient? Head back to the wards, get your cheese ready and welcome back consultant haematologist Dr Alison Chandler to the pod to teach us about infusion reactions

Timestamps:

0:53 - Yes, Nick is having a stroke
3:58 - Intro to IVIg and Rituximab
5:22 - What is IVIg?
6:46 - Where does IVIg come from
9:54 - Types of IVIg
13:58 - Indications for IVIg
19:17 - Administering IVIg
21:28 - Acute IVIg reactions
29:47 - Delayed IVIg reactions
32:31 - IVIg summary
33:36 - Intro to Rituximab
35:39 - Indications for Rituximab
40:45 - Rituximab Reactions
50:29 - Rituximab Summary

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Timestamps:

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Previous Episode

Episode 39 - Tweaks and Tune-Ups | A Guide to Blood Product Modifications

Keen to augment your blood transfusion game but confused as to when, where and why? Join the Bloody Minded boffins as we cover all the major modifications to blood products you can order. More importantly, why you should and sometimes shouldn't bother ordering them. Have a sensible conversation with your blood bank after you listen to this episode.

Timestamps:

00:58 - How the blood bank actually works

04:03 - Aged Products

07:30 - Frozen Cells

10:32 - Transfusing the Bombay phenotype

12:10 - Leukodepletion

13:57 - CMV negative

19:17 - Irradiated units

19:52 - TA-GVHD

27:58 - HLA Matching

32:46 - Take home messages

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Next Episode

Episode 41 - Transfusion for Two | HDFN and Anti-D

What’s scarier than picking blood for one patient? Picking blood for TWO patients where one of them is inside the other (or only very recently outside). Obstetrics isn’t immune to the acronym train so join Nick, Cale and Bashar as we talk about HDFN, RhD prophylaxis and that OMG sensation that comes when looking after some of our smallest patients.

Timestamps:

0:58 - Trust me this is worth it
2:30 - Episode overview
4:22 - Transfusion in pregnancy
5:52 - Kell in pregnancy
6:47 - Transfusion in neonates
9:58 - Intrauterine transfusion
11:00 - HDFN: Haemolytic Disease of the Fetus and Newborn
13:17 - Anti-D antibodies in HDFN
17:35 - Estimating FMH
20:23 - Anti-D prophylaxis
24:52 - Managing maternal alloantibodies
26:38 - Other important antibodies
31:20 - NIPT
33:00 - Episode Summary

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au