Immune System in the Gastrointestinal tract

09/12/12 • 5 min

Dr Holm Uhlig talks about the role of the immune system in our gastrointestinal tract. The gastrointestinal tract is home to more bacteria than there are cells in our body. In order to stay healthy, our immune system must maintain a strong and effective response towards these bacteria. Dr Holm Uhlig is based at the Translational Gastroenterology Unit and studies defects in the immune response and regulation leading to immunopathology. Dr Uhlig is predominately interested in children with inflammatory bowel disease, and aims to understand the complex puzzle of molecular mechanisms involved.

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Autoimmunity

Professor Richard Cornall tells us about his research on autoimmunity. Autoimmunity occurs when the immune system, which is normally designed to attack pathogens, ends up attacking the body. This can lead to a number of diseases such as diabetes and rheumatoid arthritis. Professor Richard Cornall aims to understand the causes of autoimmune disease, and also how people differ in their inherited susceptibility, and why these differences are sustained in human populations by natural selection.

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Multiple Sclerosis

Professor Lars Fugger talks about his research on multiple sclerosis. Multiple Sclerosis (MS) is a disease that affects the brain and the central nervous system. While there were no therapies for MS 20 years ago, there are now 8 registered drugs for the disease. Professor Lars Fugger focuses on translational studies in multiple sclerosis and uses a multidisciplinary approach; his group consists of both basic scientists and clinicians. Professor Fugger is seeking to understand the molecular basis for the MHC association in MS and how MHC genes interact with environmental factors such as viruses.