Your Brain On... Alzheimer’s

03/20/24 • 60 min

1 Listener

How does Alzheimer’s alter the brain, and how do we create a future without the disease?

Alzheimer’s, the most common form of dementia, threatens to single-handedly collapse our healthcare systems. But our knowledge of how to prevent it is stronger than ever.

In this episode of ‘YOUR BRAIN ON’, we discuss:

• The power of stories and the importance of community for finding comfort and confidence following an Alzheimer’s diagnosis

• What we know about preventing cognitive decline through brain-healthy living

• The neurochemistry of how Alzheimer’s physically changes the brain

• Genetic predisposition to neurodegenerative diseases, and why women have a higher risk of developing Alzheimer’s

• Why we should approach brain health in the same way we approach heart health

We’re joined by Dr. Lisa Genova, neuroscientist and writer of ‘Still Alice’, a book which allows the reader to step into the shoes of a woman experiencing the onset of Alzheimer’s. ‘Still Alice’ was adapted into a feature film, for which Julianne Moore won an Academy Award for Best Actress in 2015. Lisa talks to us about how stories can help us find a sense of hope and empathy in the face of ‘scary’ diagnoses.

Dr. Charles DeCarli, Director of the the University of California Davis Alzheimer’s Disease Center, explains a broad range of Alzheimer’s risk factors — from amyloid and tau proteins to cardiovascular diseases — and offers advice on thinking about brain health as part of the body’s wider functionality, not a standalone system.

And Dr. Lisa Mosconi, neuroscientist, educator, and author of ‘The Menopause Brain’, highlights how the hormonal shifts caused by menopause contribute to a higher prevalence of Alzheimer’s in women, and unpacks the controversial history and potential future of hormone replacement therapy.

‘Your Brain On’ is hosted by neuroscientists and public health advocates Ayesha and Dean Sherzai.

‘Your Brain On... ADHD • SEASON 1 • EPISODE 8

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LINKS

Lisa Genova:

Website and books: https://www.lisagenova.com/

Instagram: https://www.instagram.com/authorlisagenova

Lisa Mosconi:

Website: https://www.lisamosconi.com/

Instagram: https://www.instagram.com/dr_mosconi

Book, ‘The Menopause Brain’: https://www.amazon.com/Menopause-Brain-Transition-Knowledge-Confidence/dp/0593541243

Dr. Charles DeCarli at UC Davis Health: https://health.ucdavis.edu/medical-center/team/639/charles-decarli---neurology---dementia---alzheimer-s-disease-sacramento/

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Join the NEURO Academy: NEUROacademy.com

Instagram: @thebraindocs

Website: TheBrainDocs.com

More info and episodes: TheBrainDocs.com/Podcast

How does Alzheimer’s alter the brain, and how do we create a future without the disease?

Alzheimer’s, the most common form of dementia, threatens to single-handedly collapse our healthcare systems. But our knowledge of how to prevent it is stronger than ever.

In this episode of ‘YOUR BRAIN ON’, we discuss:

• The power of stories and the importance of community for finding comfort and confidence following an Alzheimer’s diagnosis

• What we know about preventing cognitive decline through brain-healthy living

• The neurochemistry of how Alzheimer’s physically changes the brain

• Genetic predisposition to neurodegenerative diseases, and why women have a higher risk of developing Alzheimer’s

• Why we should approach brain health in the same way we approach heart health

‘Your Brain On’ is hosted by neuroscientists and public health advocates Ayesha and Dean Sherzai.

‘Your Brain On... ADHD • SEASON 1 • EPISODE 8

———

LINKS

Lisa Genova:

Website and books: https://www.lisagenova.com/

Instagram: https://www.instagram.com/authorlisagenova

Lisa Mosconi:

Website: https://www.lisamosconi.com/

Instagram: https://www.instagram.com/dr_mosconi

Book, ‘The Menopause Brain’: https://www.amazon.com/Menopause-Brain-Transition-Knowledge-Confidence/dp/0593541243

Dr. Charles DeCarli at UC Davis Health: https://health.ucdavis.edu/medical-center/team/639/charles-decarli---neurology---dementia---alzheimer-s-disease-sacramento/

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Join the NEURO Academy: NEUROacademy.com

Instagram: @thebraindocs

Website: TheBrainDocs.com

More info and episodes: TheBrainDocs.com/Podcast

Previous Episode

Your Brain On... Being A Woman

1 Recommendations

Are there differences between the brains of women and men?

In this episode of Your Brain On, we explore the unique aspects of the female brain, and how the male-biased history of medical science has left us with enormous gaps in our knowledge of women’s distinctive neurology.

We discuss:

• The striking uniformity in the structure of the female and male brain

• The possible physiological and sociological reasons why women have a higher risk of developing neurodegenerative diseases like Alzheimer’s

• The recent progress that’s been made in making neuroscientific studies more inclusive

• What current research says about Hormone Replacement Therapy, a common treatment for postmenopausal drops in neuroprotective hormones

We’re joined by Dr. Margaret McCarthy, James & Carolyn Frenkil Endowed Dean's Professor at the University of Maryland School of Medicine, where she is also Professor and Chair of the Department of Pharmacology, renowned for her research into the neuroscience of sex differences, and Dr. Lise Eliot, Professor of Neuroscience at the Chicago Medical School at Rosalind Franklin University of Medicine and Science.

‘Your Brain On’ is hosted by neurologists, scientists and public health advocates, Ayesha and Dean Sherzai.

‘Your Brain On... Being A Woman • SEASON 1 • EPISODE 7

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LINKS

Dr. Margaret McCarthy’s website: https://www.mccarthylab.com/

Dr. Lise Eliot at Rosalind Franklin University: https://www.rosalindfranklin.edu/academics/faculty/lise-eliot/

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Join the NEURO Academy: NEUROacademy.com

Instagram: @thebraindocs

Website: TheBrainDocs.com

More info and episodes: TheBrainDocs.com/Podcast

Next Episode

Your Brain On... Cardio

1 Recommendations

A healthier heart equals a healthier brain — no surprise there — but what’s the neuroscience behind the benefits of a cardio workout?

Cardiovascular exercise, be it a brisk stroll, a light jog, or an intense interval training session, releases neurotransmitters that can improve your mood, reduce stress, enhance your memory, and strengthen immunity.

In this episode of ‘Your Brain On’, we discuss:

• How your brain and your body respond to increasingly challenging aerobic workouts

• The neurochemistry of phenomena like ‘feeling the burn’ and ‘runner’s high’

• How the protein BDNF, triggered by exercise, can reverse the effects of aging and cognitive decline

• Ways to integrate more cardio exercise into your life, no matter which hurdles each day brings

We speak to Dr. John Ratey, author of ‘Spark’, widely celebrated as one of THE go-to books about how exercise benefits the brain. He shares the story that led him to write the book, about a school which favored fitness over sports skills in its PE classes and subsequently ranked amid the smartest schools in the world.

We’re also joined by Dr. Art Kramer, Professor of Psychology and Director of the Center for Cognitive & Brain Health at Northeastern University, who dismisses the idea that you can be ‘too old to exercise’.

And we invite anti-influencer and social media personality Erin Azar, AKA Mrs. Space Cadet, to the show, to talk about how her videos, which show the less glamorous side of running and exercise, went viral and spawned a community of nearly one-million followers.

‘Your Brain On’ is hosted by neuroscientists and public health advocates Ayesha and Dean Sherzai.

‘Your Brain On... Cardio • SEASON 1 • EPISODE 9

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LINKS

Our ‘Mastering Memory’ training webinar: https://thebraindocs.com/memory/

Dr. John Ratey

Website and books: https://www.johnratey.com/

Dr. Art Kramer

At Northeastern University College of Science: https://cos.northeastern.edu/people/art-kramer/

Erin Azar, “Mrs. Space Cadet”

Instagram: https://www.instagram.com/immrsspacecadet

TikTok: https://www.tiktok.com/@mrs.space.cadet