We're doomed we're saved - The Biorevolution Podcast

Louise von Stechow

"We're Doomed, We're Saved" with Andreas Horchler and Louise von Stechow – father and daughter, journalist and biologist, talking about the technologies of the biorevolution. Can genetic engineering, synthetic biology, and artificial intelligence save humanity from disease, climate change, and overpopulation, or are these technologies the first step towards its downfall? Content and Editing: Louise von Stechow and Andreas Horchler Disclaimer: Louise von Stechow, Andreas Horchler and their guests express their personal opinions, which are founded on research on the respective topics but do not claim to give medical, investment, or life advice in the podcast. Learn more about the future of biotech in our podcasts and keynotes. Contact us here: scientific communication: https://science-tales.com/ Podcasts: https://www.podcon.de/ Image: Kelly Sikkema via Unsplash

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Top 10 We're doomed we're saved - The Biorevolution Podcast Episodes

Goodpods has curated a list of the 10 best We're doomed we're saved - The Biorevolution Podcast episodes, ranked by the number of listens and likes each episode have garnered from our listeners. If you are listening to We're doomed we're saved - The Biorevolution Podcast for the first time, there's no better place to start than with one of these standout episodes. If you are a fan of the show, vote for your favorite We're doomed we're saved - The Biorevolution Podcast episode by adding your comments to the episode page.

We're doomed we're saved #19

We're doomed we're saved - The Biorevolution Podcast

02/01/24 • 41 min

mRNA Therapeutics - New applications for an old molecule

RNA, one of the oldest and most versatile biomolecules, has recently entered the therapeutic arena. While for many observers the success of mRNA vaccines seemed to come out of the blue, its build on the fundament of research that has large gone ignored. Now mRNA therapeutics are enjoying the limelight of great economic success for companies like BioNTech / Pfizer and Moderna, and the awarding of the 2023 Nobel Prize to two mRNA researchers. But with the fame also comes a huge public backlash of anti-vaxxers who fear the perceived novelty of mRNAs. In the 19th episode of We're doomed, we're saved Louise von Stechow and Andreas Horchler talk with their guest, mRNA researcher Lucia Lapazio who has known the field before and after the hype.

Content and Editing: Louise von Stechow and Andreas Horchler

Disclaimer: Louise von Stechow & Andreas Horchler and their guests express their personal opinions, which are founded on research on the respective topics, but do not claim to give medical, investment or even life advice in the podcast.

Learn more about the future of biotech in our podcasts and keynotes. Contact us here: scientific communication: https://science-tales.com/ Podcasts: https://www.podcon.de/ Keynotes: https://www.zukunftsinstitut.de/louise-von-stechow

Image: s-ASFul4w-o58- via Unsplash

References: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(22)00372-2/fulltext https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(22)00372-2/fulltext https://www.scientificamerican.com/article/no-covid-mrna-vaccines-wont-damage-your-dna1/ https://www.science.org/content/article/mrna-discovery-paved-way-covid-19-vaccines-wins-nobel-prize-physiology-medicine https://www.nobelprize.org/prizes/medicine/2023/advanced-information):/ https://www.nature.com/articles/s41568-023-00586-2 https://www.nature.com/articles/s41419-022-05075-2 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0251605 https://www.nature.com/articles/s12276-022-00757-5

We're doomed we're saved #17

We're doomed we're saved - The Biorevolution Podcast

12/01/23 • 41 min

CRISPR CAS – Life’s processing tool

Gene editing technology allows humans, for the first time, to change the code of life with a precise editing system offering the potential for curing genetic diseases. The gene editing field is moving with impressive speed: after the seminal paper on the technology was published in 2012, the Nobel Prize awarded for the technology in 2020, and the first therapy approved for treatment of blood diseases in 2023. In this episode of We’re doomed, we’re saved Andreas Horchler and Louise von Stechow, discuss the tremendous potential of the technology, but also its darker side – the high cost of the therapeutic applications and the potential for augmenting, altering, and redesigning human genomes.

Content and Editing: Louise von Stechow and Andreas Horchler

Disclaimer: Louise von Stechow, Andreas Horchler and their guests express their personal opinions, which are founded on research on the respective topics, but do not claim to give medical, investment or even life advice in the podcast.

Image: Vipul Jha- via Unsplash

References: https://www.mckinsey.com/industries/life-sciences/our-insights/the-bio-revolution-innovations-transforming-economies-societies-and-our-lives https://www.mckinsey.com/industries/life-sciences/our-insights/gene-therapy-coming-of-age-opportunities-and-challenges-to-getting-ahead https://endpts.com/vertex-looking-to-right-their-rd-ship-flashes-data-suggesting-their-sickle-cell-crispr-therapy-is-working/ https://www.nature.com/articles/d41586-023-03590-6 https://www.nature.com/articles/d41586-023-01389-z https://www.nytimes.com/2005/07/03/books/chapters/more-than-human.html https://sciencehistory.org/stories/magazine/the-death-of-jesse-gelsinger-20-years-later/ https://innovativegenomics.org/news/crispr-clinical-trials-2023/ https://answers.childrenshospital.org/crispr-gene-editing/ https://www.fda.gov/vaccines-blood-biologics/cellular-gene-therapy-products/approved-cellular-and-gene-therapy-products

We're doomed we're saved #13

We're doomed we're saved - The Biorevolution Podcast

08/02/23 • 25 min

365 days We're doomed we're saved

**** GERMAN EPISODE **** Ein Jahr We're doomed we're saved - seiten einem Jahr sprechen Andreas Horchler und Louise von Stechow über die Themen der Biorevolution. Wir haben über Anitbiotikaresistenzen, Biowaffen, Gentherapien, Neuroprothesen und AI gesprochen. Wir hatten spannende Gäste, wie den Mathematiker und idalab Gründer Paul von Bünau, und den Forschungs- und Entwicklungschef von Sanofi Adventis Deutschland mit denen wir über die Rolle neuer Technologien wie AI für die Medikamentenentwicklung gesprochen haben. In dieser Folge lassen wir die erste Staffel Revue passieren und machen "A big announcment". Dies wird unsere vorerst letzte Deutsche Episode sein - in der neuen Staffel, ab September, werden wir uns auf Englisch unterhalten.

Content and Editing: Louise von Stechow and Andreas Horchler

We're doomed we're saved #5

We're doomed we're saved - The Biorevolution Podcast

12/02/22 • 31 min

Biowaffen - Neue Möglichkeiten und alte Ängste

GERMAN EPISODE Biowaffen haben zum Glück in der Geschichte der Menschheit nur selten Anwendung gefunden – sind sie doch zu unkontrollierbar. Doch mit den Technologien der Biorevolution eröffnen sich neue Möglichkeiten in der Herstellung schädlicher biologischer Agenzien – mit böser Intention von Staaten, Terroristen und sogenannten Biohackern, doch auch wohlmeinenden und unbedachten Wissenschaftlern. In dieser Folge sprechen Andreas Horchler und Louise von Stechow über die Geschichte der Biowaffen, über neue Möglichkeiten und alte Ängste.

Content and Editing: Louise von Stechow and Andreas Horchler

Image: Alex Perz Via Unsplash

References: https://futureoflife.org/2018/10/12/genome-editing-and-the-future-of-biowarfare-a-conversation-with-dr-piers-millett/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515815/ https://cen.acs.org/biological-chemistry/synthetic-biology/Synthetic-biology-enable-bioweapons-development/96/i26 https://phys.org/news/2021-11-gene-weapon.html https://www.ft.com/content/9ac7f1c0-1468-4dc7-88dd-1370ead42371 https://bigthink.com/health/covid-gain-of-function-research/ https://www.science.org/content/article/scientists-brace-media-storm-around-controversial-flu-studies https://www.theguardian.com/science/2010/may/20/craig-venter-synthetic-life-form https://www.newscientist.com/article/2272899-artificial-life-made-in-lab-can-grow-and-divide-like-natural-bacteria/ https://www.fbi.gov/history/famous-cases/amerithrax-or-anthrax-investigation

We're doomed we're saved #4

We're doomed we're saved - The Biorevolution Podcast

11/03/22 • 41 min

Gene drives - Menschengemachte Evolution

GERMAN EPISODE Sogenannte Gene Drives sind spezielle Genveränderungsmethoden, die es Wissenschaftlern zum ersten Mal erlauben die Grenzen der klassischen Evolution nach Darwin zu sprengen und ihr Grundprinzip, die natürliche Selektion zu überwinden, in dem sie die Expression in allen Nachkommen erzwingen. In dieser Episode unterhalten sich Andreas Horchler und Louise von Stechow darüber wie Gene Drives in der Malariaprävention, in der Bewahrung bedrohter Arten und zur Erhöhung von Ernteerträgen eingesetzt werden könnten – und wie gefährlich diese Technologie in der Hand eines einzelnen Wissenschaftlers sein kann.

Content and Editing: Louise von Stechow and Andreas Horchler

Image: Ryan Grybill Via Unsplash

References 1) https://www.nature.com/articles/d41586-019-02087-5 2) https://pubmed.ncbi.nlm.nih.gov/21508956/ 3) https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2021 4) https://www.statnews.com/2017/03/14/malaria-mosquitoes-burkina-faso/ 5) https://www.statnews.com/2016/12/14/gene-drive-students-igem/ 6) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675690/ 7) https://www.statnews.com/2015/12/07/gene-edited-mosquitoes-stop-malaria/ 8) https://psmag.com/ideas/most-controversial-tree-in-the-world-gmo-genetic-engineering 9) https://theconversation.com/genetically-modified-mosquitoes-could-be-released-in-florida-and-texas-beginning-this-summer-silver-bullet-or-jumping-the-gun-139710 10) https://www.editingnature.org/ 11) https://www.statnews.com/2015/11/12/gene-drive-bioterror-risk/#:~:text=The%20possibilities%20for%20%E2%80%9Cweaponizing%E2%80%9D%20gene,who%20briefed%20the%20bioweapons%20office. 12) https://www.ajtmh.org/view/journals/tpmd/96/3/article-p530.xml 13) https://elifesciences.org/articles/03401 14) https://www.pnas.org/doi/10.1073/pnas.1805874115 15) https://www.etcgroup.org/content/reckless-driving-gene-drives-and-end-nature 16) https://www.vice.com/en/article/kz49ge/this-gene-technology-could-change-the-world-its-maker-isnt-sure-it-should-v26n4 17) https://medium.com/mit-media-lab/daisy-drives-will-let-communities-alter-wild-organisms-in-local-ecosystems-cb626c5a9f38#.91i6eyhc0

We're doomed we're saved #2

We're doomed we're saved - The Biorevolution Podcast

09/01/22 • 34 min

Endliche Antibiotika - Die vertane Chance

GERMAN EPISODE Antibiotika wurden einst als Heilbringer der Menschheit gefeiert und haben dazu beigetragen die durchschnittliche Lebenserwartung stark zu erhöhen. Doch schon in den frühen Tagen warnte der Finder des Penicillins, Sir Alexander Fleming, vor dem unbedachten und verschwenderischen Umgang mit diesen Wundermedikamenten. In dieser Folge beleuchten Andreas Horchler und Louise von Stechow die weltweite Gesundheitskrise, die von antibiotikaresistenten Bakterien hervorgerufen wird und besprechen ihre Ursachen und potentielle Gegenmaßnahmen.

Content and Editing: Louise von Stechow and Andreas Horchler

Image: CDC via Unsplash

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378521/ (antibiotic resistance overview)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354621/ (antibiotic resistance overview, altered life expectancy)
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02724-0/fulltext (antibiotic resistance overview, Lancet study)
https://www.bbc.com/news/health-60058120 (antibiotic resistance overview, Lancet study overview)
https://www.who.int/data/stories/the-true-death-toll-of-covid-19-estimating-global-excess-mortality (COVID death statistics WHO)
https://www.cdc.gov/media/releases/2015/p0225-clostridium-difficile.html (C diff)
https://www.cell.com/trends/genetics/fulltext/S0168-9525(20)30206-7 (Horizontal gene transfer)
https://wellcome.org/news/why-is-it-so-hard-develop-new-antibiotics (the difficulties in developing novel antibiotics
https://www.nature.com/articles/d41586-020-02884-3 (Nature, why big pharma abandoned antibiotics)
https://www.nature.com/articles/d41586-018-02475-3 (Nature - 4 stories of antibiotic breakthroughs)
https://www.umu.se/en/news/-new-group-of-antibacterial-molecules-identified_11112855/ (new antibiotics, Karolinska and Uni Bonn)
https://pubmed.ncbi.nlm.nih.gov/26089440/#:~:text=Teixobactin%20is%20a%20recently%20described,(provisionally%20named%20Eleftheria%20terrae). (new antibiotics, Teixobactin)
https://www.nature.com/articles/s41586-021-03899-0 (new antibiotics, rational design)
https://news.mit.edu/2020/artificial-intelligence-identifies-new-antibiotic-0220#:~:text=Using%20a%20machine%2Dlearning%20algorithm,resistant%20to%20all%20known%20antibiotics. (new antibiotics, MIT AI)

We're doomed we're saved #1

We're doomed we're saved - The Biorevolution Podcast

08/04/22 • 40 min

Die Biorevolution - Risiken und Versprechen

GERMAN EPISODE Die Biorevolution bringt viele neue Technologien, mit großen Versprechungen, aber auch unkalkulierbaren Risiken. In dieser Folge geben Andreas Horchler und Louise von Stechow einen Überblick über die Technologien der Biorevolution und sprechen über die Möglichkeit den Menschen selbst, seine Gene und sein Gehirn zu revolutionieren und über die Unmöglichkeit biologische Agenzien zu kontrollieren, die sich nicht um menschengemachte Regeln, Grenzen und ethische Bedenken kümmern. Erscheint montatlich am 1.

Content and Editing: Louise von Stechow and Andreas Horchler

Image: Isis França via Unsplash

References https://www.mckinsey.com/business-functions/mckinsey-digital/our-insights/how-the-bio-revolution-could-transform-the-competitive-landscape https://peh-med.biomedcentral.com/articles/10.1186/s13010-020-00089-0 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193163/ https://theconversation.com/science-fiction-explores-the-interconnectedness-revealed-by-the-coronavirus-pandemic-139021 https://lab.cccb.org/en/terraforming-the-earth-redesigning-the-world/ https://www.nature.com/articles/429591b

We're doomed we're saved #12

We're doomed we're saved - The Biorevolution Podcast

07/03/23 • 33 min

Follow the money - Die Geldquellen der Biowissenschaften

**** GERMAN EPISODE **** Follow the money, folge dem Geld, ist eine alte Weisheit wenn man den Kern einer Angelegenheit verstehen will. In der 12. Folge von We're doomed we're saved folgen wir diesem Weg zu den Geldquellen der Biomedizinischen Forschung, zu Regierungszuschüssen, großen Pharmaunternehmen und privaten Stiftungen, wie der Bill und Melinda Gates Foundation, die ganze Forschungszweige quasi im Alleingang finanziert. Solche privaten Geldgeber haben besonders in den USA einen großen Einfluss auf die Forschungslandschaft, obwohl ihre Auswahlkriterien und Transparenz umstritten sind und die Verbindung von Wissenschaftlern und reichen Technokraten das Vertrauen in die Wissenschaft verringern kann.

Content and Editing: Louise von Stechow and Andreas Horchler

Image: Andre Taissin via Unsplash

References https://www.nature.com/articles/d41586-023-00077-2 https://sciencephilanthropyalliance.org/philanthropy-a-critical-player-in-supporting-scientific-research-alliance-blog/ https://arxiv.org/abs/2206.10661 https://www.technologynetworks.com/tn/news/science-is-becoming-less-disruptive-368887 https://sciencephilanthropyalliance.org/science-philanthropy-engagement-with-minority-serving-institutions-the-why-how-and-what/ https://www.science.org/content/article/what-kind-researcher-did-sex-offender-jeffrey-epstein-fund-he-told-science-he-died https://www.gatesmri.org/ https://www.forbes.com/sites/siladityaray/2023/01/17/gates-foundation-ceo-defends-philanthropys-influence-on-global-health/?sh=6e4af7894be2 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2808%2961485-3/fulltext?version=printerFriendly https://www.nature.com/articles/d41586-020-01452-z https://www.wired.com/story/opinion-the-world-loses-under-bill-gates-vaccine-colonialism/ https://www.wired.com/story/opinion-the-dangers-of-relying-on-philanthropists-during-pandemics/ https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2808%2961485-3/fulltext?version=printerFriendly https://www.scidev.net/global/news/gates-foundation-reviews-funding-focus-after-criticism/ https://www.thelancet.com/journals/lancet/article/PIIS0140673609608850/fulltext?rss=yes https://www.nytimes.com/2019/09/07/business/mit-media-lab-jeffrey-epstein-joichi-ito.html https://www.theguardian.com/us-news/2019/aug/18/private-jets-parties-and-eugenics-jeffrey-epsteins-bizarre-world-of-scientists

We're doomed we're saved #11

We're doomed we're saved - The Biorevolution Podcast

06/01/23 • 39 min

Die Zukunft der Pharmaindustrie - Neue Technologien und Modelle

**** GERMAN EPISODE **** Wie werden neue Technologien, wie die künstliche Intelligenz die Pharmaindustrie beeinflussen? Welche neuen Modelle werden die Blockbuster der Vergangenheit ablösen? In dieser Folge sprechen wir mit unserem Gast Professor Jochen Maas, Geschäftsführer Forschung & Entwicklung Sanofi-Aventis, Deutschland GMBH über die Zukunft der Pharmaindustrie

Content and Editing: Louise von Stechow and Andreas Horchler

Image: Amanda Marie via Unsplash

We're doomed we're saved #30

We're doomed we're saved - The Biorevolution Podcast

01/03/25 • 39 min

New year old me – no biohacks needed

2025: For millions of people, the new year starts with the self-promise to improve, to quit smoking, alcohol, to get in shape, to stay young and attractive, to basically create and become a new me. While traditionally new year vows meant to relinquish, today there seem to be many helpers in the form of biohacking. Beginning with diets and not ending with technical devices. While there are real shortcuts and fake abbreviations to reach some of those goals, there ́s also traditional ways. In "New year old me – no biohacks needed", Louise von Stechow and Andreas Horchler try to distinguish what ́s worth trying and what to avoid.

Image: Lucas Favre, via Unsplash. Further reading:

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How many episodes does We're doomed we're saved - The Biorevolution Podcast have?

We're doomed we're saved - The Biorevolution Podcast currently has 30 episodes available.

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The podcast is about Life Sciences, Pharma, Biotech, Natural Sciences, Podcasts, Science and Artificial Intelligence.

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The episode title 'We're doomed we're saved #21' is the most popular.

What is the average episode length on We're doomed we're saved - The Biorevolution Podcast?

The average episode length on We're doomed we're saved - The Biorevolution Podcast is 37 minutes.

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Episodes of We're doomed we're saved - The Biorevolution Podcast are typically released every 30 days, 1 hour.

When was the first episode of We're doomed we're saved - The Biorevolution Podcast?

The first episode of We're doomed we're saved - The Biorevolution Podcast was released on Aug 4, 2022.

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We're doomed we're saved - The Biorevolution Podcast

Louise von Stechow

Top 10 We're doomed we're saved - The Biorevolution Podcast Episodes

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How many episodes does We're doomed we're saved - The Biorevolution Podcast have?

What topics does We're doomed we're saved - The Biorevolution Podcast cover?

What is the most popular episode on We're doomed we're saved - The Biorevolution Podcast?

What is the average episode length on We're doomed we're saved - The Biorevolution Podcast?

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