Cutting-Edge Developments in Military Vascular Surgery and Regenerative Medicine: Col. (Ret.) W. Darrin Clouse, MD, FACS

Join us for an enlightening discussion with Dr. Darrin Clouse, a retired Air Force Colonel and esteemed vascular surgeon, as we explore the modernization of military medicine. With over two decades of experience, including deployments to Iraq and Afghanistan, Dr. Clouse shares his invaluable insights on the complexity and multiplicity of vascular injuries in combat settings. Hear about his role in developing endovascular platforms, and the challenges he faced treating severe blast injuries with extensive vascular damage. Dr. Clouse also highlights the unmet needs in vascular surgery, emphasizing the necessity for infection-resistant conduits and advancements in temporary shunting techniques.

We also delve into Human Acellular Vessels (HAV) 's exciting potential in medical and military applications. Dr. Clouse discusses the successful implementation of HAVs in Ukraine and the upcoming FDA adjudication that could bring these life-saving technologies to trauma centers across the U.S. The conversation extends to the logistical challenges of deploying HAVs in battlefield settings and the future of regenerative medicine. Additionally, discover the significance of the WarDocs and OpMed TV partnership, which aims to document and preserve the rich history of military medicine. Don't miss Dr. Clouse's valuable advice for young individuals considering a career in military medicine, highlighting the unparalleled learning experiences and opportunities for growth in this field.

Chapters:

(00:04) Optimizing Military Medicine Through Modernization

(11:02) Advances in Military Medicine Technology

Chapter Summaries:

(00:04) Optimizing Military Medicine Through Modernization

This chapter features a conversation with Dr. Darrin Clouse, a retired Air Force Colonel and vascular surgeon currently leading the Vascular and Endovascular Surgery Division at the University of Virginia Health. We explore his military career, which spanned over two decades and included deployments to Iraq and Afghanistan, where he played a crucial role in developing endovascular platforms and addressing complex vascular injuries. Dr. Clouse contrasts the differences between military and civilian vascular injuries, emphasizing the complexity and multiplicity of wounds in a combat setting. He recounts a particularly challenging case involving a severe blast injury with extensive vascular and hollow viscous damage. Additionally, we discuss unmet needs in vascular surgery, such as the necessity for an off-the-shelf, infection-resistant conduit, highlighting the importance of timely revascularization and advancements in temporary shunting techniques.

(11:02) Advances in Military Medicine Technology

This chapter focuses on the current status and future potential of acellular vessels (HAV) in medical and military applications. We explore the promising results from recent uses in Ukraine, where HAVs have been successfully implemented in 18 patients with severe arterial injuries. The discussion touches on the regulatory landscape, highlighting an upcoming FDA adjudication that could make HAVs widely available in trauma centers across the U.S. We also consider the logistical aspects of deploying HAVs in battlefield settings, particularly within different roles of military medical care. The conversation extends to the future of regenerative medicine, envisioning a world where lab-grown vessels can seamlessly replace damaged arteries and veins. Finally, valuable advice is offered for young individuals considering a career in military medicine, emphasizing unparalleled learning experiences and opportunities for growth within the field.

Take Home Messages:

1. Advancements in Battlefield Vascular Surgery: The episode highlights the unique challenges of treating vascular injuries in combat zones, particularly those caused by blasts. Significant progress has been made in developing endovascular platforms and temporary shunting techniques, which are critical for timely revascularization and improving patient outcomes in military settings.
2. Innovative Use of Acellular Vessels: The discussion covers the promising future of human acellular vessels (HAV) in both military and civilian medical applications. These vessels, which are engineered to be infection-resistant and conducive to cell infiltration, have shown positive results in recent uses in Ukraine, with potential for broader application pending FDA approval.
3. Logistical Challenges and Solutions: Deploying advanced medical technologies like HAVs in battlefield scenarios presents logistical hurdles. The episode explores how these technologies could be integrated into different roles of military medical care, emphasizing the need for definitive vascular reconstructions to be performed at more resourced medical facilities.
4. Regenerative Medicine’s Potential: The episode envisions a future where lab-grown vessel...