Tiny Matters

In 2021, 80,411 people in the United States died of an overdose involving opioids, making up 75% of all drug overdose deaths that year. That’s also 10 times as many opioid overdose deaths as in 1999. How did we get here?
In this episode, Sam and Deboki trace the origins of opioids, from opium and morphine to fentanyl, and scrutinize the significant role pharmaceutical companies played in kick starting the opioid crisis in the 1990s. Today, the highly potent opioid fentanyl has become the street supply of opioids, which has led to a steep incline in overdose deaths. On top of that, it can be adulterated with dangerous substances like xylazine or "tranq." Now more than ever, facilities focused on harm reduction are crucial. These facilities allow for safe needle exchange, which reduces the risk of transmitting diseases like HIV and hepatitis C, and also provide opioid users with treatment and access to other healthcare testing.
Although the opioid crisis is a tragic reality in this country, harm reduction, increased opioid research funding, and hefty pharmaceutical company payouts are providing glimmers of hope.
In the US, the Substance Abuse and Mental Health Services Administration (SAMHSA) has a National Helpline for individuals and family members facing mental and/or substance use disorders. It can be reached at 1-800-662-HELP (1-800-662-4357). It is confidential, free, in both English and Spanish, and open 24/7, 365 days a year. The helpline provides referrals to local treatment facilities, support groups, and community-based organizations.
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Although we look very different from many of the other creatures on this planet, we’re more connected than you might think. Our evolutionary history means we share many of the same genes and physiology, and that’s not just cool to think about — it’s useful. Because it means that, to learn about the things we lack or wish we could do better, we can study the exceptional abilities of other animals.
In today's episode, Sam and Deboki cover two species with extreme lifestyles— brown bears and Mexican cave fish — and what they are teaching us about avoiding blood clots and fatty liver disease, and how that could unlock the potential for new treatments. In this week’s Tiny Show and Tell, Sam asks "What is a species?" and Deboki ponders how a mushroom could grow out of a living frog.
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A week ago, the Metropolitan Museum of Art held its 2024 Met Gala — a yearly event to raise money for the Costume Institute. The gala also marks the opening of the Costume Institute's annual show, which this year is called "Sleeping Beauties: Reawakening Fashion." The idea behind this exhibit is to showcase pieces from the museum's collection that are too delicate to show on mannequins. Instead, the exhibit will feature recreations of the pieces using AI and 3-D techniques, along with sound and smell. But what about textiles that museums choose to display — how is science used to maintain these incredible, often fragile, pieces of the past?
In this episode of Tiny Matters, Sam and Deboki cover the fascinating textile landscape, from plant-based fibers to the evolution of modern synthetic materials and the investigative approaches used to preserve not just these fabrics but also the stories they tell and the cultural significance they hold.
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Links to the Tiny Show & Tell stories are here and here. Pick up a Tiny Matters mug here! All Tiny Matters transcripts are available here.

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In the early hours of January 7, 2022, David Bennett was out of options. At just 57 years old, he was bedridden, on life support, and in desperate need of a heart transplant for which he was ineligible. Yet Bennett would go on to live for two more months — not with a human heart, but with a heart from a pig. David Bennett was the first case of a pig heart being transplanted into a human, an example of xenotransplantation — when the cells, tissues or organs from one species are transplanted into another. In the United States, over 100,000 kids and adults are currently on the national transplant waiting list, and every day around 17 people on that list die while waiting.

In today's episode, we cover the science and historical research that made Bennett’s transplant possible, and what doctors learned from him that helped the next heart xenotransplant recipient, Lawrence Faucette, live even longer. We also get into some of the ethics conversations surrounding xenotransplantation work — not just questions about the use of animals like pigs and baboons, but experiments with recently deceased, i.e. brain dead, people.
Check out Jyoti Madhusoodanan's Undark story, "The Allure and Dangers of Experimenting With Brain-Dead Bodies" here. Her JAMA story we mention, also on xenotransplantion, is here.
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On April 20, 2010, a drilling rig called Deepwater Horizon exploded, capsizing 36 hours later. Eleven workers were killed and, over the next 87 days, more than 100 million gallons of oil spilled into the Gulf of Mexico in what the EPA has called the largest marine oil spill in history. With public distrust of the companies responsible mounting, scientists had to find a way to study the spill and communicate what they found. So when faced with a crisis of this magnitude, when the stakes are so high, how do you dispel misinformation and effectively communicate what you know? Find links to buy Chris Reddy's book Science Communication in a Crisis: An Insider's Guide here. The Tiny Show & Tell stories are here and here. Pick up a Tiny Matters mug here! All Tiny Matters transcripts are available here.

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