TWiP 185: Latrinalia

07/03/20 • 63 min

Dickson, Daniel and Vincent solve the case of the Wife of a Guy with Cyclospora Diarrhea, and discuss the discovery of an intrinsic oscillator that drives the bloodstream stage cycle of the malaria parasite.

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin

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Links for this episode

Intrinsic oscillator in malaria parasite (Science)
Malaria parasite has intrinsic clock (Science)
Letters read on TWiP 185

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Case Study for TWiP 185

Seeing this type of case 1/week for last several weeks. 75 yo female, admitted with fever, body aches, cough, loose stool for 2 week, sodium 118. Sheltering in place in Long Island, some gardening, no travel. Blood testing detected low sodium. COVID-19 negative, no other symptoms. Blood work: wbc 2000; hematocrit 24; platelets 40; sodium 120s. Unremarkable physical exam. Lyme test negative; other tick borne diseases negative.

Send your case diagnosis, questions and comments to [email protected]

Music by Ronald Jenkees

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin

Subscribe (free): iTunes, Google Podcasts, RSS, email

Links for this episode

Intrinsic oscillator in malaria parasite (Science)
Malaria parasite has intrinsic clock (Science)
Letters read on TWiP 185

Become a patron of TWiP

Case Study for TWiP 185

Send your case diagnosis, questions and comments to [email protected]

Music by Ronald Jenkees

Previous Episode

TWiP 184: The hunter gets captured by the game

Dickson, Daniel and Vincent solve the case of the Safari Goer With Watery Diarrhea, and explain how a microsporidian endosymbiont of Anopheles mosquitoes might impair the transmission of malaria.

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin

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Contribute to Parasites Without Borders
Microsporidian impairs Plasmodium transmission (Nat Comm)
Hero: Eugene T. Lyons (obituary)
Image credit: Josh
Letters read on TWiP 184

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Case Study for TWiP 184

69 yo female with several months of abdominal symptoms started in S. Africa, water shortage as described for her husband in the previous TWiP. Husband had C. cayetanensis. Her symptoms improved; her stool was positive for B. hominis and E. nana. Given many different treatments. Then comes to see Daniel. Some abdominal discomfort, mucosy stools. All past med/surg unremarkable, nothing in family, sent for repeat labs, stool O&P all normal including GI PCR

Send your case diagnosis, questions and comments to [email protected]

Music by Ronald Jenkees

Next Episode

TWiP 186: Not rationing rationality

Dickson, Daniel and Vincent solve the case of the Elder Gardener Feeling Poorly, and discuss the three-dimensional ultrastructure of Plasmodium falciparum during cytokinesis.

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin

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Links for this episode

Three-dimensional structure of malaria parasite (PLoS Path)
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Letters read on TWiP 186

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Case Study for TWiP 186

Middle aged woman quite upset, referred to Daniel. Sheltering at home, one day looking at her children, noticed problem with vision. When covers right eye, notices area of loss of vision in left eye. No other associated symptoms. Admitted to hospital, blood tests, eye exam (lesion in back of eye had developed). Blood: WNV serology, another was done but he’s not saying. Comes back positive. No cat or dog exposure. Healthy, no prior medical problems, no surgeries, no toxic habits, HIV unknown, married.

Send your case diagnosis, questions and comments to [email protected]

Music by Ronald Jenkees