TWiP 180: A spleen palaver

02/08/20 • 81 min

The TWiP professors solve the case of the Ugandan Child with Splenomegaly, and reveal that mutations in the P. falciparum genome that confer artemisinin resistance interfere with endocytic uptake of hemoglobin.

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin

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Endocytosis pathway mediates artemisinin resistance in malaria parasites (Science)
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Case Study for TWiP 180

Uganda with a twist. Meets two people with watery diarrhea, 12 episodes/day, loss of appetite. No fever, no blood in stool. Living for months at staff guest house. One week prior to onset went on weekend trip to area with waterfalls. Were served outdoor meal: meat, salad, fruit. Recommends empiric treatment trimethoprim/sulfamethoxzole for 7 days. Prompt resolution of diarrhea. A few days later, upon drinking coffee with milk gets severe cramps. 20s, long term female volunteers.

Send your case diagnosis, questions and comments to [email protected]

Music by Ronald Jenkees

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin

Subscribe (free): iTunes, Google Podcasts, RSS, email

Links for this episode

PWB social media: Facebook, Instagram, Twitter
Endocytosis pathway mediates artemisinin resistance in malaria parasites (Science)
Letters read on TWiP 180

Become a patron of TWiP.

Case Study for TWiP 180

Send your case diagnosis, questions and comments to [email protected]

Music by Ronald Jenkees

Previous Episode

TWiP 179: Verminous visitors

The TWiP DVD solve the case of the Child Who Passed Worms, and discuss a non-human primate model for severe malarial anemia.

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin

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Primate model of severe malarial anemia (Sci Rep)
Ascaris skirt (and more!)
Hero: Harold W. Brown
Letters read on TWiP 179

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Case Study for TWiP 179

From Uganda, eastern up in mountains, rainy season. 6 yo girl brought in by mother on Monday, reporting several days of feeling poorly, headache, fever, muscle aches. Negative malaria smear on Monday. Wednesday returns, feeling worse, fever higher, headache worse. Lungs clear, belly (pain on left side) has large spleen. Living in good conditions, well dressed, dirt floor house, concrete walls. Toilet is hole in back. Same dietary habits, high in carbs. No mosquito netting. Water from stream. No siblings. HIV negative.

Send your case diagnosis, questions and comments to [email protected]

Music by Ronald Jenkees

Next Episode

TWiP 181: Daniel's drive-through

Dickson, Daniel and Vincent solve the case of the Two Volunteers With Watery Diarrhea, discuss diagnosis of SARS-CoV-2 in the New York area, and reveal an approach to preventing honeybee colony collapse by imbuing their gut bacteria with the ability to produce antiviral and antiparasite double-stranded RNAs.

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin

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Links for this episode

PWB social media: Facebook, Instagram, Twitter
Daniel on TWiV Special
Engineered symbionts limit honeybee pathogens (Science)
Letters read on TWiP 181

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Case Study for TWiP 181

Risks of being helpful. Volunteer from previous case. Diarrhea is gone, now has second issue. Since coming to Uganda noticing on waking in AM often has series of 1 cm red raised lesions in a line, 3-4, on torso. Swollen and itchy. New ones in the AM. Manager says welcome to Uganda. They move out of room, leave bedding behind. Lesions stop. What is going on and when can they move back into room?

Send your case diagnosis, questions and comments to [email protected]

Music by Ronald Jenkees