TWiP 179: Verminous visitors

01/11/20 • 103 min

The TWiP DVD solve the case of the Child Who Passed Worms, and discuss a non-human primate model for severe malarial anemia.

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin

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Primate model of severe malarial anemia (Sci Rep)
Ascaris skirt (and more!)
Hero: Harold W. Brown
Letters read on TWiP 179

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Case Study for TWiP 179

From Uganda, eastern up in mountains, rainy season. 6 yo girl brought in by mother on Monday, reporting several days of feeling poorly, headache, fever, muscle aches. Negative malaria smear on Monday. Wednesday returns, feeling worse, fever higher, headache worse. Lungs clear, belly (pain on left side) has large spleen. Living in good conditions, well dressed, dirt floor house, concrete walls. Toilet is hole in back. Same dietary habits, high in carbs. No mosquito netting. Water from stream. No siblings. HIV negative.

Send your case diagnosis, questions and comments to [email protected]

Music by Ronald Jenkees

The TWiP DVD solve the case of the Child Who Passed Worms, and discuss a non-human primate model for severe malarial anemia.

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin

Subscribe (free): iTunes, Google Podcasts, RSS, email

Links for this episode

PWB social media: Facebook, Instagram, Twitter
Primate model of severe malarial anemia (Sci Rep)
Ascaris skirt (and more!)
Hero: Harold W. Brown
Letters read on TWiP 179

Become a patron of TWiP.

Case Study for TWiP 179

Send your case diagnosis, questions and comments to [email protected]

Music by Ronald Jenkees

Previous Episode

TWiP 178: The shadowlands of medicine

The Knights of the TWiP solve the case of the Man Who Lost Weight, and discuss a Plasmodium protein kinase that is a malarial drug target.

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin

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Links for this episode

PWB social media: Facebook, Instagram, Twitter
Protein kinase as malaria drug target (Science)
Hero: Myron Schultz
Letters read on TWiP 178

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Case Study for TWiP 178

Eastern border of Uganda with Kenya, in mountains. Drinking water from nearby stream. Two young boys come to clinic, without parents. Sent in by grandmother because 1 yo brother has been passing worms. Long, white, flat. Shown photos in PD7, pinkish worm, 8 inches long, round. He points to those, what he has been seeing in brother’s stool. 1 year old seems small, protuberant abdomen; brother small for stated age, bit of protuberant belly. Diet: high carbohydrate, flour deep fried; yams; cabbage; some rice; soybeans; pumpkin; bananas.

Send your case diagnosis, questions and comments to [email protected]

Music by Ronald Jenkees

Next Episode

TWiP 180: A spleen palaver

The TWiP professors solve the case of the Ugandan Child with Splenomegaly, and reveal that mutations in the P. falciparum genome that confer artemisinin resistance interfere with endocytic uptake of hemoglobin.

Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin

Subscribe (free): iTunes, Google Podcasts, RSS, email

Links for this episode

PWB social media: Facebook, Instagram, Twitter
Endocytosis pathway mediates artemisinin resistance in malaria parasites (Science)
Letters read on TWiP 180

Become a patron of TWiP.

Case Study for TWiP 180

Uganda with a twist. Meets two people with watery diarrhea, 12 episodes/day, loss of appetite. No fever, no blood in stool. Living for months at staff guest house. One week prior to onset went on weekend trip to area with waterfalls. Were served outdoor meal: meat, salad, fruit. Recommends empiric treatment trimethoprim/sulfamethoxzole for 7 days. Prompt resolution of diarrhea. A few days later, upon drinking coffee with milk gets severe cramps. 20s, long term female volunteers.

Send your case diagnosis, questions and comments to [email protected]

Music by Ronald Jenkees