TWiP 177: A scabrous education
11/06/19 • 89 min
The TWiPsters solve the case of the Rashy Schoolteacher, and reveal a drug from rotifers that live on the snail intermediate host which paralyzes schistosome cercariae and prevents infection of mice.
Hosts: Vincent Racaniello, Dand Daniel Griffin
Subscribe (free): iTunes, Google Podcasts, RSS, email
Links for this episode- Progress towards global eradication of dracunculiasis (MMWR)
- Rotifer compound that paralyzes schistosome cercariae (PLoS Biol)
- Image credit
- Letters read on TWiP 177
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Case Study for TWiP 17749 yo man sent to Daniel for ID consultation. Reports in August visited Hawaii with family, then flies to CA. Family event there. Take him to Pakistani restaurant. One day later has gastrointestinal issues, nausea, diarrhea. Goes to urgent care, send stool for O&P. Look at stool, shows chilomastix mesnili. No medicines, will be ok. Over this period of 1 week he loses 15 pounds. Gains 5 back. End of October feels fine, no bloating or diarrhea. No symptoms but goes to gastroenterologist. Stool test returns with D. fragilis; and chilomastix mesnili. Now sees Daniel. Not on any meds. No allergies, no toxic habits, athletic. No illness in family. Normal exam. He ate salads in Hawaii.
Send your case diagnosis, questions and comments to [email protected]
Music by Ronald Jenkees
The TWiPsters solve the case of the Rashy Schoolteacher, and reveal a drug from rotifers that live on the snail intermediate host which paralyzes schistosome cercariae and prevents infection of mice.
Hosts: Vincent Racaniello, Dand Daniel Griffin
Subscribe (free): iTunes, Google Podcasts, RSS, email
Links for this episode- Progress towards global eradication of dracunculiasis (MMWR)
- Rotifer compound that paralyzes schistosome cercariae (PLoS Biol)
- Image credit
- Letters read on TWiP 177
Become a patron of TWiP.
Case Study for TWiP 17749 yo man sent to Daniel for ID consultation. Reports in August visited Hawaii with family, then flies to CA. Family event there. Take him to Pakistani restaurant. One day later has gastrointestinal issues, nausea, diarrhea. Goes to urgent care, send stool for O&P. Look at stool, shows chilomastix mesnili. No medicines, will be ok. Over this period of 1 week he loses 15 pounds. Gains 5 back. End of October feels fine, no bloating or diarrhea. No symptoms but goes to gastroenterologist. Stool test returns with D. fragilis; and chilomastix mesnili. Now sees Daniel. Not on any meds. No allergies, no toxic habits, athletic. No illness in family. Normal exam. He ate salads in Hawaii.
Send your case diagnosis, questions and comments to [email protected]
Music by Ronald Jenkees
Previous Episode
TWiP 176: Blood schmear
The TWiPpers of the bite fantastic solve the case of the Indian Man Who Hiked, and discuss the effects of schistosome soluble egg antigen on infection of lymphocytes with HIV-1.
Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin
Subscribe (free): iTunes, Google Podcasts, RSS, email
Links for this episode- Effect of schistosome soluble egg antigen on HIV-1 infection (PLoS P)
- Hero: Lawson Soulsby
- Letters read on TWiP 176
Become a patron of TWiP.
Case Study for TWiP 176Recent case, woman in late 20s, schoolteacher. Outer boroughs of NYC. Wakes up on Saturday, completely rash-y, head to toe. Goes to urgent care center, say is allergic, give anti histamines and steroids. Persists after a few days, goes to allergist. Only allergen positive, dust mites. Few days later goes to GP, still itchy and rash-y. He does more thorough exam, notices she has small red lesions on fingers and between fingers. Several children in classes she is teaching has similar malady. Given therapeutic, rash goes away. Otherwise healthy, HIV negative. Partner not around at the time this develops.
Send your case diagnosis, questions and comments to [email protected]
Music by Ronald Jenkees
Next Episode
TWiP 178: The shadowlands of medicine
The Knights of the TWiP solve the case of the Man Who Lost Weight, and discuss a Plasmodium protein kinase that is a malarial drug target.
Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin
Subscribe (free): iTunes, Google Podcasts, RSS, email
Links for this episode- PWB social media: Facebook, Instagram, Twitter
- Protein kinase as malaria drug target (Science)
- Hero: Myron Schultz
- Letters read on TWiP 178
Become a patron of TWiP.
Case Study for TWiP 178Eastern border of Uganda with Kenya, in mountains. Drinking water from nearby stream. Two young boys come to clinic, without parents. Sent in by grandmother because 1 yo brother has been passing worms. Long, white, flat. Shown photos in PD7, pinkish worm, 8 inches long, round. He points to those, what he has been seeing in brother’s stool. 1 year old seems small, protuberant abdomen; brother small for stated age, bit of protuberant belly. Diet: high carbohydrate, flour deep fried; yams; cabbage; some rice; soybeans; pumpkin; bananas.
Send your case diagnosis, questions and comments to [email protected]
Music by Ronald Jenkees
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