
TWiP 172: A painless lesion
06/14/19 • 103 min
Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin
The metacyclic TWiPomastigotes solve the case of the Child With a Painless Leg Lesion, and reveal how to kill mosquitoes with a genetically modified fungus.
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- Transgenic Metarhizium kills mosquitoes (Science)
- Hero: Veena Tandon
- Letters read on TWiP 172
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Case Study for TWiP 172Retired US Navy physician, lives aboard his sailboat, just finished doing remote medical volunteer work in C. America. In DR when has sudden onset of dull prog worsening epigastric lower abdominal pain. Over next 12 hr intensifies, near tears, went to local medical center. Admitted, given IV, probiotics. Febrile, elevated WBC 20,000, platelets low, white counts left shift. Initially some constipation, then diarrhea with some blood. Discharged without diagnosis; still fever and chills; rash rose colored spots on torso. Daniel gets involved; 3 day course of azithromycin, symptoms continue; then metronidazole, feels better, fever, pain, symptoms resolve. Wife is ok. Three men working on his boat, one had bloody diarrhea before the patient did. Keeps a bowl of nuts around.
Send your case diagnosis, questions and comments to [email protected]
Music by Ronald Jenkees
Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin
The metacyclic TWiPomastigotes solve the case of the Child With a Painless Leg Lesion, and reveal how to kill mosquitoes with a genetically modified fungus.
Subscribe (free): iTunes, Google Podcasts, RSS, email
- Transgenic Metarhizium kills mosquitoes (Science)
- Hero: Veena Tandon
- Letters read on TWiP 172
Become a patron of TWiP.
Case Study for TWiP 172Retired US Navy physician, lives aboard his sailboat, just finished doing remote medical volunteer work in C. America. In DR when has sudden onset of dull prog worsening epigastric lower abdominal pain. Over next 12 hr intensifies, near tears, went to local medical center. Admitted, given IV, probiotics. Febrile, elevated WBC 20,000, platelets low, white counts left shift. Initially some constipation, then diarrhea with some blood. Discharged without diagnosis; still fever and chills; rash rose colored spots on torso. Daniel gets involved; 3 day course of azithromycin, symptoms continue; then metronidazole, feels better, fever, pain, symptoms resolve. Wife is ok. Three men working on his boat, one had bloody diarrhea before the patient did. Keeps a bowl of nuts around.
Send your case diagnosis, questions and comments to [email protected]
Music by Ronald Jenkees
Previous Episode

TWiP 171: Better than a sharp stick in the eye
The Leishmaniacs solve the case of the Child With Band Keratopathy, and reveal a eukaryotic parasite with functional mitochondria but without mitochondrial genomes.
Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin
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Links for this episode:- Elmer Pfefferkorn, 87
- Eukaryotic parasite without mitochondrial genomes (Sci Adv)
- Hero: Charles Wardell Stiles
- Letters read on TWiP 171
By boat to remote village, young boy (
Next Episode

TWiP 173: Rose colored spots
Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin
The podcastellani hosts solve the case of the Sailor With Dysentery, and reveal the first virus discovered in Plasmodium species.
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Links for this episode:- Matryoshka RNA virus of Plasmodium (bioRxiv)
- Hero: Rose Gana Fomban Leke
- Letters read on TWiP 173
Become a patron of TWiP.
Case Study for TWiP 173Successful individual in NY area with 9 months of epigastric pain. Did upper endoscopy, saw in stomach several small mobile white serpiginous moving objects. 2.8 mm. Seem to be trying to burrow into gastric mucosa. One grabbed and sent to lab. History: curious habit of curing his own protein sources.
Send your case diagnosis, questions and comments to [email protected]
Music by Ronald Jenkees
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