Dec 2, 2022 This Week in Cardiology Podcast
12/02/22 • 24 min
SGLT2 inhibitors, publishing choices, second and third order effects of interventions, decision support, and patient selection for preventive procedures are the topics John Mandrola, MD, discusses in this week’s podcast.
This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic
I. EMPA Kidney
EMPA-Kidney Seals SGLT2 Inhibitors as 'Foundational' for CKD https://www.medscape.com/viewarticle/984439
EMPA-Kidney Moves the Needle for SGLT2 Inhibitors in Kidney Disease https://www.medscape.com/viewarticle/983521
Empagliflozin in Patients with Chronic Kidney Disease https://www.nejm.org/doi/pdf/10.1056/NEJMoa2204233
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy https://www.nejm.org/doi/10.1056/NEJMoa1811744
Dapagliflozin in Patients with Chronic Kidney Disease https://www.nejm.org/doi/full/10.1056/NEJMoa2024816
Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: collaborative meta-analysis of large placebo-controlled trials https://doi.org/10.1016/S0140-6736(22)02074-8
II. Publishing Choices
Motorcycle Rallies Linked to Spike in Organ Transplants https://www.medscape.com/viewarticle/984623
Organ Donation and Transplants During Major US Motorcycle Rallies https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2798550
III. Second and Third Order Effects
Heart Disease Deaths Spiked During COVID After 10-Year Decline https://www.medscape.com/viewarticle/984605
IV. Decision Support
Patient App Aids Decisions on Anticoagulants: ENHANCE-AF https://www.medscape.com/viewarticle/984253
A Randomized Clinical Trial to Evaluate an Atrial Fibrillation Stroke Prevention Shared Decision‐Making Pathway https://www.ahajournals.org/doi/10.1161/JAHA.122.028562
V. Percutaneous Left Atrial Appendage Closure
Consider Life Expectancy When Referring for LAA Closure? https://www.medscape.com/viewarticle/981117
Transcatheter Left Atrial Appendage Occlusion: A Multi-Center Real Life Experience https://www.mdpi.com/2077-0383/11/23/6944
Incidence and Predictors of Early Death in Patients Undergoing Percutaneous Left Atrial Appendage Closure https://www.jacc.org/doi/full/10.1016/j.jacep.2022.06.012
Indications for Left Atrial Appendage Occlusion in the United States and Associated In-Hospital Outcomes: Results From the NCDR LAAO Registry https://www.ahajournals.org/doi/full/10.1161/CIRCOUTCOMES.121.008418
You may also like:
Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine
The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact [email protected]
SGLT2 inhibitors, publishing choices, second and third order effects of interventions, decision support, and patient selection for preventive procedures are the topics John Mandrola, MD, discusses in this week’s podcast.
This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic
I. EMPA Kidney
EMPA-Kidney Seals SGLT2 Inhibitors as 'Foundational' for CKD https://www.medscape.com/viewarticle/984439
EMPA-Kidney Moves the Needle for SGLT2 Inhibitors in Kidney Disease https://www.medscape.com/viewarticle/983521
Empagliflozin in Patients with Chronic Kidney Disease https://www.nejm.org/doi/pdf/10.1056/NEJMoa2204233
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy https://www.nejm.org/doi/10.1056/NEJMoa1811744
Dapagliflozin in Patients with Chronic Kidney Disease https://www.nejm.org/doi/full/10.1056/NEJMoa2024816
Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: collaborative meta-analysis of large placebo-controlled trials https://doi.org/10.1016/S0140-6736(22)02074-8
II. Publishing Choices
Motorcycle Rallies Linked to Spike in Organ Transplants https://www.medscape.com/viewarticle/984623
Organ Donation and Transplants During Major US Motorcycle Rallies https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2798550
III. Second and Third Order Effects
Heart Disease Deaths Spiked During COVID After 10-Year Decline https://www.medscape.com/viewarticle/984605
IV. Decision Support
Patient App Aids Decisions on Anticoagulants: ENHANCE-AF https://www.medscape.com/viewarticle/984253
A Randomized Clinical Trial to Evaluate an Atrial Fibrillation Stroke Prevention Shared Decision‐Making Pathway https://www.ahajournals.org/doi/10.1161/JAHA.122.028562
V. Percutaneous Left Atrial Appendage Closure
Consider Life Expectancy When Referring for LAA Closure? https://www.medscape.com/viewarticle/981117
Transcatheter Left Atrial Appendage Occlusion: A Multi-Center Real Life Experience https://www.mdpi.com/2077-0383/11/23/6944
Incidence and Predictors of Early Death in Patients Undergoing Percutaneous Left Atrial Appendage Closure https://www.jacc.org/doi/full/10.1016/j.jacep.2022.06.012
Indications for Left Atrial Appendage Occlusion in the United States and Associated In-Hospital Outcomes: Results From the NCDR LAAO Registry https://www.ahajournals.org/doi/full/10.1161/CIRCOUTCOMES.121.008418
You may also like:
Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine https://www.medscape.com/features/public/machine
The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact [email protected]
Previous Episode
Nov 18, 2022, This Week in Cardiology
AHA 2022, Part 2: IRONMAN, ECMO-CS, CTS-AMI, and PROGRESSIVE AF are the trials John Mandrola, MD, reviews in this week’s podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Pushback on PROMINENT
Zimerman Thread: https://twitter.com/AndreZimerman/status/1593019800036708353
II. IRONMAN
IRONMAN Galvanizes Case for IV Iron Repletion in Heart Failure
https://www.medscape.com/viewarticle/984030
Is Iron Replacement in Heart Failure Worth the Trouble?
https://www.medscape.com/viewarticle/983622
Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial https://doi.org/10.1016/S0140-6736(22)02083-9
III. ECMO-CS
Avoid Routine Early ECMO in Severe Cardiogenic Shock: ECMO-CS
https://www.medscape.com/viewarticle/983618
Extracorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock: Results of the ECMO-CS Randomized Clinical Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.062949
Venoarterial Extracorporeal Membrane Oxygenation for Cardiogenic Shock and Cardiac Arrest https://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.118.004905
IV. CTS-AMI
Chinese Herbal Medicine May Offer Benefits in STEMI: CTS-AMI
https://www.medscape.com/viewarticle/983619
V. PROGRESSIVE AF
First-Line AF Ablation Cuts Risk of Progression vs Drug Therapy
https://www.medscape.com/viewarticle/983882
Role of Ablation Type and Risk Factors in Paroxysmal AF: PROGRESSIVE-AF Interview https://www.medscape.com/viewarticle/983474
Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation
https://www.nejm.org/doi/full/10.1056/nejmoa2029980
Progression of Atrial Fibrillation after Cryoablation or Drug Therapy
https://www.nejm.org/doi/10.1056/NEJMoa2212540
Natural History of Subclinical Atrial Fibrillation Detected by Implanted Loop Recorders
https://pubmed.ncbi.nlm.nih.gov/31779791/
You may also like:
Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine
https://www.medscape.com/features/public/machine
The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD.
https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact
Next Episode
Dec 9, 2022 This Week in Cardiology Podcast
Nudges, statins, AI, less-is-more in the ICU, myocarditis, exercise as medicine, and December in the hospital are the topics John Mandrola, MD, covers in this week’s podcast.
This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Nudges and Statin Prescribing
EHR Alerts to Both Doc and Patient May Boost Statin Prescribing
https://www.medscape.com/viewarticle/984944
Effect of Nudges to Clinicians, Patients, or Both to Increase Statin Prescribing
https://jamanetwork.com/journals/jamacardiology/article-abstract/2798971
Association of the Hospital Readmissions Reduction Program With Mortality Among Medicare Beneficiaries Hospitalized for Heart Failure, Acute Myocardial Infarction, and Pneumonia
https://jamanetwork.com/journals/jama/fullarticle/2719307
Lack of Efficacy of a Salience Nudge for Substituting Selection of Lower-Calorie for Higher-Calorie Milk in the Work Place https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488787/
II. AI and Chest X-Ray
Single Chest X-Ray Could Predict 10-Year CVD Risk
https://www.medscape.com/viewarticle/984910
III. BOX Trial
Shorter Fever Prevention Duration Effective After Cardiac Arrest
https://www.medscape.com/viewarticle/984852
Duration of Device-Based Fever Prevention after Cardiac Arrest
https://www.nejm.org/doi/10.1056/NEJMoa2212528
Oxygen Targets in Comatose Survivors of Cardiac Arrest
https://www.nejm.org/doi/full/10.1056/NEJMoa2208686
Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest
https://www.nejm.org/doi/full/10.1056/NEJMoa2208687
Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure
https://www.nejm.org/doi/full/10.1056/NEJMoa2032510
IV. Myocarditis
Mortality Higher in Myocarditis After Virus Than After COVID Vax
https://www.medscape.com/viewarticle/985045
Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination
https://link.springer.com/article/10.1007/s00392-022-02129-5#Tab2
Myopericarditis After COVID-19 mRNA Vaccination Among Adolescents and Young Adults
https://jamanetwork.com/journals/jamapediatrics/fullarticle/2798866
Prognosis of Myocarditis Developing After mRNA COVID-19 Vaccination Compared With Viral Myocarditis
https://www.jacc.org/doi/full/10.1016/j.jacc.2022.09.049
V. Exercise as Medicine
Just 8 Minutes of Exercise a Day Is All You Need
https://www.medscape.com/viewarticle/984684
Vigorous physical activity, incident heart disease, and cancer: how little is enough? https://doi.org/10.1093/eurheartj/ehac572
You may also like:
Medscape editor-in-chief Eric Topol, MD, and master storyteller and clinician Abraham Verghese, MD, on Medicine and the Machine
https://www.medscape.com/features/public/machine
The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD.
https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact [email protected]
John M Mandrola, MD
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