#249 ‒ How the brain works, Andrew’s fascinating backstory, improving scientific literacy, and more | Andrew Huberman, Ph.D.

04/03/23 • 170 min

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Andrew Huberman is a Professor of Neurobiology at Stanford University and host of the Huberman Lab podcast. In this episode, Andrew begins with a fascinating discussion about the brain, including the role of the prefrontal cortex in adjusting your ruleset to match your setting, the neural circuitry underlying the ability of stress to limit creativity and problem-solving, the effect of belief on physiology and performance, and more. He speaks about vision being our “superpower” and compares this to animals that rely more on other senses. Next, he opens up about his personal journey, the struggles and losses he has overcome, the value of therapy, and the many great people who helped him along the way. He speaks to his love of biology and discovery and the importance of staying true to your passion rather than being driven purely by ambition. Lastly, the conversation includes a look to the future of Andrew's scientific work and podcast as well as his unique approach to communicating science and tackling the issue of scientific illiteracy.

We discuss:

Exercise under blood flow restriction, lactate utilization, and transient changes in the brain function in response to adrenaline and stress [3:30];
The role of the prefrontal cortex in governing rulesets [9:15];
New discoveries about the circuitry between the prefrontal cortex, insula, and amygdala, and the insights gleaned about brain function in different emotional states [15:30];
Comparing human vision and other senses to animals [26:00];
A deep dive into vision: evolutionary adaptations, facial recognition, color, and more [39:45];
Sense of smell, pheromones, and why evolution developed better vision over smell [46:30];
The relationship between visual input and time perception [55:30];
Mindset effects: the effect of belief on physiology and performance [1:00:45];
Accessing higher levels of creativity with broadening rulesets and the limiting nature of stress and fear on creativity [1:05:30];
Stress and fear increase autonomic arousal, limit access to rulesets, and inhibit performance [1:12:15];
Andrew’s upbringing, early childhood, and tough adolescent years [1:15:00];
Andrew’s time in a residential treatment program and how he benefited from therapy [1:20:15];
The beginning of positive changes in Andrew’s young life [1:28:30];
Andrew’s decision to turn his life around [1:37:00];
A new passion for science and exercise helps Andrew [1:42:00];
The difference between a postdoc and a PhD [1:54:15];
Staying in touch with the love of biology and not getting pulled into ambition [1:59:15];
Andrew starts his own lab, and continues work to overcome his demons [2:07:00];
The loss of three mentors leads to deep soul searching [2:12:00];
What motivated Andrew to begin his podcast [2:18:00];
Looking to the future of Andrew’s scientific work, podcast, and more [2:22:45];
Andrew’s unique approach to communicating science and the issue of scientific illiteracy [2:30:00]; and
More.

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View the Show Notes Page for This Episode

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We discuss:

Exercise under blood flow restriction, lactate utilization, and transient changes in the brain function in response to adrenaline and stress [3:30];
The role of the prefrontal cortex in governing rulesets [9:15];
New discoveries about the circuitry between the prefrontal cortex, insula, and amygdala, and the insights gleaned about brain function in different emotional states [15:30];
Comparing human vision and other senses to animals [26:00];
A deep dive into vision: evolutionary adaptations, facial recognition, color, and more [39:45];
Sense of smell, pheromones, and why evolution developed better vision over smell [46:30];
The relationship between visual input and time perception [55:30];
Mindset effects: the effect of belief on physiology and performance [1:00:45];
Accessing higher levels of creativity with broadening rulesets and the limiting nature of stress and fear on creativity [1:05:30];
Stress and fear increase autonomic arousal, limit access to rulesets, and inhibit performance [1:12:15];
Andrew’s upbringing, early childhood, and tough adolescent years [1:15:00];
Andrew’s time in a residential treatment program and how he benefited from therapy [1:20:15];
The beginning of positive changes in Andrew’s young life [1:28:30];
Andrew’s decision to turn his life around [1:37:00];
A new passion for science and exercise helps Andrew [1:42:00];
The difference between a postdoc and a PhD [1:54:15];
Staying in touch with the love of biology and not getting pulled into ambition [1:59:15];
Andrew starts his own lab, and continues work to overcome his demons [2:07:00];
The loss of three mentors leads to deep soul searching [2:12:00];
What motivated Andrew to begin his podcast [2:18:00];
Looking to the future of Andrew’s scientific work, podcast, and more [2:22:45];
Andrew’s unique approach to communicating science and the issue of scientific illiteracy [2:30:00]; and
More.

Connect With Peter on Twitter, Instagram, Facebook and YouTube

Previous Episode

#248 ‒ OUTLIVE book: A behind-the-scenes look into the writing of this book, motivation, main themes, and more

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After more than six years of research, planning, and writing, Peter’s book, Outlive: The Science and Art of Longevity, is officially available as of March 28th. In this episode, Peter sits down with co-author Bill Gifford to provide a behind-the-scenes look into the writing process, including the motivation for making it happen, how the book evolved over the course of the writing process, and why certain topics were chosen (and omitted). Additionally, they discuss how the book is structured and touch on a few of the book’s main themes to give potential readers an idea of what they can expect.

We discuss:

The meaning of the book’s title and subtitle [3:00];
Finding the right art for the book cover [9:00];
Who is Bill Gifford, and how did he get involved in the book? [16:15];
How Peter’s writing evolved over the six years it took to write this book [25:00];
The structure of the book and what people can expect to learn [29:00];
How the writing of the book and the podcast interviews have shaped Peter’s thinking and approach to translating science [32:45];
Making the book stand the test of time despite the constant evolution of science and medicine [36:00];
Objective, strategy, and tactics [39:30];
Exciting possible progressions in science and medicine over the next decade [42:15];
What is holding back “medicine 3.0” from being the norm? [46:00];
How the book compares to the podcast in terms of technicality and readability for the layman [49:00];
Motivation to write the book and insights into challenges around the writing process [57:15];
Peter’s decision to be the reader for the audiobook [1:10:30];
The many painstaking last-minute changes and edits that brought the book together and made it better [1:19:00];
Peter and Bill’s favorite parts of the book [1:27:30];
The incredible team of people supporting the book [1:31:30]; and
More.

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Next Episode

#250 ‒ Training principles for longevity | Andy Galpin, Ph.D. (PART II)

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Andy Galpin is a Professor of Kinesiology at California State University at Fullerton, where he studies muscle adaptation and applies his research to work with professional athletes. In this episode, Andy returns to the podcast and continues the conversation about training for longevity. He examines the training practices of powerlifters, Olympic weightlifters, Strongmen/women, CrossFit athletes, and sprinters in order to extract insights that can be applied to the individual wanting to optimize for longevity. Andy goes into detail about exercise load and repetition, training volume, the importance of learning proper movement patterns, the advantage of working to technical failure instead of the number of reps, and much more. Andy ties the discussion together by providing a hypothetical training plan for an individual wanting to optimize for longevity and offers advice for avoiding injury.

We discuss:

Review of the function and organization of skeletal muscle [3:15];
Review of muscle fiber types [9:30];
Hypertrophy: changes in muscle fibers and the underlying mechanisms that make a muscle grow [19:30];
Defining sarcoplasmic hypertrophy and how it relates to the number of reps in a set [30:15];
Training for maximum strength: what we can learn from powerlifters and a hypothetical training plan [32:45];
Ideal reps, volume, and load for the powerlifter [44:45];
What should powerlifters do on their off days? [56:45];
Are there consequences of powerlifting on long-term health? [1:02:00];
Defining Olympic weightlifting: a test of power [1:04:30];
Training principles of Olympic weightlifting [1:07:45];
Tracking power output when training [1:17:15];
Frequency of training for Olympic weightlifting [1:22:15];
How post-activation potentiation (and the opposite) can improve power training and speed training [1:24:30];
The Strongman competition: more breadth of movement, strength, and stamina [1:32:00];
Training principles of Strongmen and advice for someone new to the Strongman competition [1:36:45];
CrossFit: a combination of weightlifting movements, endurance, and circuit training [1:50:15];
Learning from elite athletes, heart rate recovery, V02 max, and other metrics [1:58:45];
Optimizing towards being a well-rounded athlete as opposed to a specialist [2:09:45];
What we can learn from the sprinters about speed, acceleration, peak velocity, and technique [2:17:45];
A training plan for the “centenarian athlete” [2:24:30];
Debunking some training and exercise myths [2:33:00];
The “do nots” of training and tips for avoiding injury [2:34:15]; and
More.