
Oprah and Dr. Ania Jastreboff on How People Treat You Differently After Weight Loss
01/21/25 • 59 min
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In this episode of The Oprah Podcast, Oprah continues her conversation with Dr. Ania Jastreboff, an endocrinologist and associate professor at the Yale School of Medicine, about the anti-obesity GLP-1 medications that are changing the world of weight loss. Oprah and Dr. Ania talk about what happens to a person’s mental health, body image and how the world treats them after losing a significant amount of weight. Joined by clinical psychologist Dr. Rachel Goldman, assistant professor at NYU Grossman School of Medicine, Oprah and Dr. Ania speak to people using the GLP-1 medications like long-time Harpo producer, Brian Piotrowicz, who reveals how people treat him differently now that he’s lost a significant amount of weight in a short period of time. Several other guests from across the country also share how their lives have changed after GLP-1 weight loss including a woman who lost over 160 pounds. Finally, we will get an update from several guests that appeared on the ABC Oprah Special: Shame, Blame and the Weight Loss Revolution including high school student Maggie who lost over 100 pounds.
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In this episode of The Oprah Podcast, Oprah continues her conversation with Dr. Ania Jastreboff, an endocrinologist and associate professor at the Yale School of Medicine, about the anti-obesity GLP-1 medications that are changing the world of weight loss. Oprah and Dr. Ania talk about what happens to a person’s mental health, body image and how the world treats them after losing a significant amount of weight. Joined by clinical psychologist Dr. Rachel Goldman, assistant professor at NYU Grossman School of Medicine, Oprah and Dr. Ania speak to people using the GLP-1 medications like long-time Harpo producer, Brian Piotrowicz, who reveals how people treat him differently now that he’s lost a significant amount of weight in a short period of time. Several other guests from across the country also share how their lives have changed after GLP-1 weight loss including a woman who lost over 160 pounds. Finally, we will get an update from several guests that appeared on the ABC Oprah Special: Shame, Blame and the Weight Loss Revolution including high school student Maggie who lost over 100 pounds.
For more information on Dr. Rachel Goldman
Follow Dr. Rachel on Instagram
Follow Michaela on TikTok
Follow Michaela on Instagram
Follow Anna on Instagram
Follow Jewell on TikTok
Follow Jewell on Instagram
Follow Jewell on YouTube
Follow Marissa on Instagram
Follow Marissa on TikTok
Follow Oprah’s Producer Brian on Instagram
Watch Part 1 Here.
SUPPORT THE SHOW
Subscribe: https://www.youtube.com/@Oprah
Follow Oprah Winfrey on Social:
Listen to the full podcast:
#oprahsbookclub
Learn more about your ad choices. Visit megaphone.fm/adchoices
Previous Episode

Dr. Ania Jastreboff
In this episode of The Oprah Podcast, Oprah sits down with Dr. Ania Jastreboff, an endocrinologist and associate professor at the Yale School of Medicine, to talk about the new GLP-1 medications like Ozempic, Wegovy, Mounjaro and Zepbound. Dr. Ania, who has been on the forefront of GLP-1 medication research for the past 20 years, will talk through why it is biologically difficult for some people to lose weight, maintain weight loss and why obesity is a disease. She explains how the new GLP-1 medications work, how they can facilitate weight loss, and if they are safe. Dr. Ania answers questions from people around the country who are taking the GLP-medications and have lost a significant amount of weight. We will also share an update from Amy Kane who told her story of losing 160 pounds on weight loss medications last year on Oprah’s ABC Special: Shame, Blame and the Weight Loss Revolution.
Also referenced in this episode: "The Let Them Theory: A Life-Changing Tool That Millions of People Can’t Stop Talking About" by Mel Robbins, published by Hay House LLC is available wherever books and audio books are sold.
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Oprah and Business Leader Mellody Hobson Share the Money Advice You Need to Know Now
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In this episode of The Oprah Podcast, financial expert and Co-CEO and President of Ariel Investments, Mellody Hobson, offers practical advice to simplify financial conversations for families.
Mellody shares details about struggling with money as a child, lessons she's taught her daughter and fascinating historical facts about money from her New York Times best-selling children's book, "Priceless Facts About Money."
People from around the country join via Zoom to ask Mellody how to address financial questions and situations with their children.
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