The Immunology Podcast

Guest:

Dr. Shana Kelley is the President of the Chan Zuckerberg Biohub Chicago and the Neena B. Schwartz Professor of Chemistry and Biomedical Engineering at Northwestern University. The Kelley research group works in a variety of areas spanning bio analytical technology development and has pioneered new methods for tracking molecular and cellular analytes with unprecedented sensitivity. She talks about developing DNA-based reagentless biosensors and commercializing new technologies.

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The Immunology Science Round Up

Tuberculosis Target Structure – Cryogenic electron microscopy structures of Mycobacterium tuberculosis ATP synthase sheds light on drug binding.

Toll-Like Receptor Signaling – Researchers engineered macrophages to delineate TLR pathway activities.

Onco-Fetal Immune Tolerance – Scientists cross-analyzed single-cell RNA sequencing data from human cancer types and the maternal-fetal interface to identify an onco-fetal immune tolerance checkpoint.

Tau Immunotherapy – Scientists loaded tau antibodies into micelles and administered them intranasally in mice.

Image courtesy of Dr. Shana Kelley

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Guest:

Dr. Priya Devarajan is an Assistant Professor at Stony Brook University. Her work focuses on immune memory and respiratory immunology. She talks about how aging affects the immune system and strategies to promote immune responses in the nose and lungs. She also discusses improving influenza vaccine responses and her experience interviewing for faculty positions.

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The Immunology Science Round Up

γδ T Cells Across the Life Span – Antigenic exposures over childhood drive the functional evolution and tissue compartmentalization of γδ T cells.

Glucose Restriction and Viral Response – Glucose restriction is a physiological mechanism to bring the body into a heightened state of responsiveness to viral pathogens.

A Gene Desert Implicated in Autoimmunity – Researchers used functional genomics to identify a central regulator of human inflammatory macrophages.

Stripy T Cells – Some T cells within a population have nuclear envelope invaginations that concentrate cellular organelles.

Image courtesy of Dr. Priya Devarajan

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Guest:

Dr. Erika Moore is an Assistant Professor in the Fischell Department of Bioengineering at the University of Maryland, where her lab is committed to engineering biomaterial models that harness the regenerative potential of the immune system. She talks about building biomaterials, rejuvenating macrophages, and treating lupus. She also discusses using the right cells in research and promoting financial literacy to make science careers more accessible.

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The Immunology Science Round Up

Heart Failure – Bone marrow can carry an innate immune memory of cardiac stress that may exacerbate heart failure.

Epstein Barr and B Cells – Virus-orchestrated NAD biosynthesis is a druggable metabolic vulnerability of Epstein Barr virus-driven B cell transformations.

Microbiome Modulation in Pregnancy – Bacterial conversion of corticoids into progestins may affect host physiology, particularly in the context of pregnancy.

The Circadian Rhythm and Tumor Immunosuppression – Circadian gating of tumor immunosuppression informs the timing and efficacy of immune checkpoint inhibitors.

Image courtesy of Dr. Erika Moore

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Guest:

Dr. Kellen Cavagnero is a Postdoctoral Fellow at the University of California, San Diego. His PhD work focused on how fibroblasts — a cell type thought to be immunologically inert — contribute to chronic inflammatory conditions and defense against pathogens. He talks about staph infections, antimicrobial resistance, and the types and roles of fibroblasts. He also discusses his work in science communication, including his podcast, Inflammatory Content.

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The Immunology Science Round Up

Malaria Immunity – Scientists leveraged a human malaria infection study to investigate functional correlates of immunity.

CAR T Therapy for HIV – Anti-HIV-1 CAR-T cells armed with endogenic broadly neutralizing antibodies resulted in significant suppression of viral rebound in HIV patients.

Immunogenic Cell Death – Researchers generated a small-molecule proteolysis-targeting chimera that selectively degraded human and murine RIPK1.

Origins of Autoimmunity – NUDCD3 is required for healthy T and B cell development in humans.

Image courtesy of Dr. Kellen Cavagnero

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In May 2024, we attended IMMUNOLOGY2024, the annual meeting of the American Association of Immunologists, in Chicago. We spoke with delegates about their research and impressions of the meeting, including their reasons for attending and the most memorable research presented.

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