The Human Upgrade with Dave Asprey
Dave Asprey
For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human UpgradeTM.
You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.
Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.
Join The Human UpgradeTM with Dave Asprey on this next evolution to upgrade your mind, body and life.
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Top 10 The Human Upgrade with Dave Asprey Episodes
Goodpods has curated a list of the 10 best The Human Upgrade with Dave Asprey episodes, ranked by the number of listens and likes each episode have garnered from our listeners. If you are listening to The Human Upgrade with Dave Asprey for the first time, there's no better place to start than with one of these standout episodes. If you are a fan of the show, vote for your favorite The Human Upgrade with Dave Asprey episode by adding your comments to the episode page.
How to Build Strength Faster – John Jaquish, Ph.D., with Dave Asprey, Part 2 : 863
The Human Upgrade with Dave Asprey
10/01/21 • 44 min
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In Part 1 of our two-part episode with John Jaquish, Ph.D., I talked with him about building bone density—an important factor in your strength and longevity. Don’t miss! Building Strength Isn’t About Weight Lifting Anymore – John Jaquish, Ph.D., with Dave Asprey, Part 1 – #862.
This inventor, author, and scientist created OsteoStrong and the X3 System, a series of devices that combine rehabilitation and advancements in human physiology to build bone density. His extensive research into bone density and strength found that you can approach weight lifting much differently than you may think.
“It appears that the most biological adaptation comes from not the area under the curve, the total volume of work you did, but has to do with how quickly did you go from zero to 100 and back to zero,” John says. “So, a very brief spike of almost anything causes way more adaptation than spiking up to 70% and holding it.”
Now in Part 2, our conversation dives into John’s other findings and lifestyle choices, both as a public figure, a mentor for professional athletes and a fasting enthusiast. We go off the beaten path on a few things:
- Anabolic rebound after fasting (what fasting does to build muscle mass)
- Tendon mutations (and how they make people outrageously strong)
- Taking Viagra (or other non-pharmaceuticals) and carbs to trigger a muscle cell splitting
- The difference between fructose, glucose and sucrose (is there any real difference in the body?)
We also talk about ways to eat for strength and the quest for longevity that guides him. He knows about the tempting danger of eating to only look good (but you feel like crap). He offers tips to make sure you don’t go there.
Check out John’s book to learn more: Weight Lifting Is a Waste of Time: So Is Cardio, and There’s a Better Way to Have the Body You Want
Enjoy! And get more resources at Dave.Asprey/podcasts. Got a comment, idea or question for the podcast? Submit via this form.
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The Bacteria That Lets You Drink Alcohol Again – Zack Abbott, Ph.D. : 1000
The Human Upgrade with Dave Asprey
11/29/22 • 55 min
(ZBiotics sponsored this episode.)
IN THIS EPISODE OF THE HUMAN UPGRADETM... you'll find out how to counter the sometimes rough morning after you have alcohol. The key is a new genetically engineered pre-alcohol probiotic drink. Great timing as you head into the holiday season of celebrations.
Zack Abbott, CEO & co-founder of ZBiotics, joins this 1,000th episode of the podcast to talk about new discoveries in alcohol metabolism, genetic engineering and GMOs (used in a good way!), and the power of microbes.
Ever wondered why you feel like crap the morning after drinking alcohol? The cause is a byproduct called acetaldehyde that forms in your gut when you drink alcohol. The ZBiotics Pre-Alcohol Probiotic Drink breaks down acetaldehyde while you drink so you can feel better the morning after.
Prior to starting ZBiotics, Zack, who has a Ph.D. in microbiology and immunology, worked in clinical trial design, researched HIV vaccines, and pursued novel antibiotics in both academia and industry.
He invented the ZBiotics proprietary technology using genetic engineering to develop new probiotics—ones with specific, unique abilities to improve your daily life. He’s proving through science that incredible things can be done with GMOs and genetically engineered microbes.
SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://zbiotics.com/dave and use code "dave" to save 15%.
Watch this episode on YouTube!
Biostack for High Performance: https://vatellia.com, use code DAVE2022 to save 10% or subscribe and save 15% + receive a free bottle of Kale Buster
Harness Cold to Improve Health & Performance: https://www.cryobuilt.com
Business Growth With SEO: https://www.stephanspencer.com, get a FREE consultation
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Improve your Vision Forever with These Three FREE Exercises | Dr. Bryce Appelbaum : 1240
The Human Upgrade with Dave Asprey
01/09/25 • 57 min
What if you could ditch your glasses forever by simply doing a 10-minute exercise each day?
In this episode, Dave sits down with Dr. Bryce Appelbaum, a visionary in vision biohacking, to uncover how simple techniques can transform your eyesight. From near-far focusing to eye stretches, these exercises don’t just improve your vision—they enhance your brain’s performance, energy, and overall health.
Dr. Bryce shares his own journey of overcoming severe vision challenges, the science behind vision training, and how anyone can rewire their brain for sharper sight. If you’re dealing with nearsightedness, eye strain, or just want to keep your eyes sharp as you age, this episode shares simple ways to improve how you see the world—literally!
What You’ll Learn:
• Why vision training is the next frontier in biohacking
• Three free techniques to improve your vision naturally
• How your eyesight affects brain performance and energy levels
• Why kids and adults need to get outside for better eye health
• How to train your eyes to stop relying on glasses
Go to www.screenfit.com/enroll and use code DAVE ($200 OFF with the code)
Or
Visit myvisionfirst.com/dave/ for 5000$ off the premium concierge program!
Sponsors
Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.
Resources:
• 2025 Biohacking Conference – https://biohackingconference.com/2025
• Screenfit- Visit https://www.screenfit.com/enroll and use code DAVE ($200 OFF with the code, from $497 to $297)
• MyVisionFirst – Visit https://myvisionfirst.com/dave/ and apply now to get $5000 off
• Danger Coffee – https://dangercoffee.com
• Dave Asprey’s Website – https://daveasprey.com
• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books
• Dave Asprey’s Linktree – https://linktr.ee/daveasprey
• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com
• Own an Upgrade Labs – https://ownanupgradelabs.com
• Upgrade Labs – https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com
Timestamps:
• 00:00 Intro
• 00:29 Dave Asprey’s Vision Journey
• 04:33 Understanding Vision Beyond 20/20
• 08:01 Impact of Environment on Vision
• 22:47 Exercises to Improve Vision
• 27:29 Effective Eye Exercises for Better Vision
• 27:46 Daily Routine for Eye Health
• 29:12 Peripheral Vision Training
• 31:15 Vision and Body Connection
• 33:38 Handling Visual Overload
• 35:04 Vision Training Benefits
• 39:25 Neuroplasticity and Vision
• 45:22 Vision Training for All Ages
• 46:38 Practical Vision Improvement Tips
• 54:24 Final Thoughts on Vision Training
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Upgrade Spotlight: How to Fight Zombie Cells and Win Aging – Neurohacker Collective : 1009
The Human Upgrade with Dave Asprey
01/07/23 • 32 min
Neurohacker Collective sponsored this episode.
IN THIS "UPGRADE SPOTLIGHT" EPISODE OF THE HUMAN UPGRADETM... you’re going to learn about the zombie cells taking up valuable space in your body and how you can clear them out with senolytics.
When these zombie cells accumulate (formally called senescent cells), they negatively impact how you age. You may experience symptoms like joint discomfort, low mental and physical energy, poor metabolic health, and diminished muscular response when you work out.
Naturopathic physician Greg Kelly joins the show from Neurohacker Collective, where he’s director of Product Development. His expertise includes nootropics, anti-aging and regenerative medicine, weight management, sleep, and the chronobiology of performance and health.
The hallmarks of aging include nine characteristics that organisms all the way up to humans share as we age, Dr. Kelly explains. One of those characteristics is senescent cells.
This discussion gets into the reasons why senescence happens, the science of senolytics, exciting new research, and new product developments that help bodies naturally eliminate senescent cells. This means a better aging process for you!
SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://neurohacker.com/dave and code ASPREY to get an additional 15% off. You can trial Qualia Senolytic for up to 100 days with a full 100% money-back guarantee.
Watch this episode on YouTube!
9th Annual Biohacking Conference: Come join like-minded people June 22-24 in Orlando, Florida, for three days of awesome! You’ll learn from dozens of experts at an amazing event that’s designed to upgrade every area of your life. https://biohackingconference.com
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Finding Your True North Through Yoga – Baron Baptiste : 991
The Human Upgrade with Dave Asprey
10/27/22 • 66 min
IN THIS EPISODE OF THE HUMAN UPGRADETM... you’ll learn how a yoga practice can be a vehicle for inner transformation. This conversation looks past the popularity of yoga as a fitness trend and into its deeper potential for human development. You’ll also learn how yoga can be a way for you to explore your whole being—from physicality to emotions to thinking.
“A yoga practice often can be the missing ingredient for people,” says renowned yoga master Baron Baptiste. “Often I hear, ‘I added yoga practice to my routine and regimen, and it just shifted everything for me.’ It's a very different way of working your body, mind and breath integration.”
Baron devotes his own life to the study and practices of human development. For more than 30 years, he’s facilitated education through yoga principles and teachings.
His power vinyasa yoga— The Baptiste Methodology—includes the physical (asana), meditation (dhyana) and inquiry (niyama).
“Iyengar was one of my primary teachers,” Baron says. “One thing I borrowed from him is the rigor to a body alignment—a True North Alignment.”
Baptiste Yoga is a systematic approach made up of 53 poses, or asanas, that are linked together by connective momentum and consist of five classical pillars: Drishti (gaze), ujjayi (breath), bandhas (foundation), tapas (heat) and vinyasa (flow).
More about Baron Baptiste: Baron began to seriously study yoga at age 12. As the son of two of America's yoga pioneers, he’s got a great life story that highlights the transformative power of yoga. He trained extensively in all the major traditions before beginning to teach yoga in Los Angeles in the late 80s and creating Baptiste Power Vinyasa Yoga in the mid-90s. He’s worked with celebrities, Olympians and professional athletes. He founded the Baptiste Power Yoga Institute that reaches people around the world. Baron’s also a New York Times bestselling author of multiple books, Emmy-award film maker and public speaker.
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Do You Have Cancer? A New Whole-Body MRI Scan Sees Everything – Dr. Raj Attariwala : 989
The Human Upgrade with Dave Asprey
10/21/22 • 62 min
Prenuvo sponsored this episode.
IN THIS EPISODE OF THE HUMAN UPGRADETM... you’ll find out about a new healthcare model that’s putting you fully in control of your health with whole-body MRI scans.
Dr. Raj Attariwala, Prenuvo’s founding radiologist, joins the show to explain how Prenuvo gives you early insight into what’s going on under your skin. His Ph.D. in Biomedical Engineering and medical degree in Nuclear Medicine and Radiology informed how he created Prenuvo’s whole-body MRI device software. Here’s what Prenuvo’s scans can do:
- detect nine of the 10 top cancers in stage one
- detect nearly 500 other medical conditions
- look at degeneration of the spine and body composition
- look at the blood in the brain and the blood vessels in the center of the brain
Dave visited Prenuvo’s new Los Angeles facility right before the start of the 8th Annual Biohacking Conference in Beverly Hills to talk with Dr. Raj about Prenuvo’s innovative take on the MRI scan. With AI, Prenuvo’s bringing in quantitative reproducibility, which means you can start to see subtle changes throughout your body over time.
In this conversation, you’ll learn
- Why it’s so important to know your health baseline instead of waiting for symptoms to present and disease to progress. The reactive medical system in the U.S. focuses on disease management after it occurs.
- What types of medical issues show up that may be overlooked or dismissed by your primary care doctor or other medical professionals. Existing annual checkups are relatively useless.
- How Prenuvo’s whole-body MRI scans can give you an “age score” for your physiology that you can track over time. This means you can make proactive, informed decisions about your own health.
SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Get a $300 discount off Prenuvo’s Whole Body Scan ($2,199 instead of $2,499). You’ll get your scan images and radiologic analysis via your smartphone app or the web. Book online: https://prenuvo.com/DAVE or book via phone: 1-833-PRE-NUVO (1-833-773-6886); mention code “DAVE." This discount is valid through March 10, 2023, in all Prenuvo clinics throughout the U.S. and Canada.
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Sleep Breakthroughs, Stacks & Solutions – Matt Gallant : 996
The Human Upgrade with Dave Asprey
11/11/22 • 68 min
BiOptimizers sponsored this podcast.
IN THIS EPISODE OF THE HUMAN UPGRADETM... you're going to get into bed with the topic of sleep. Pretty much everyone’s favorite.
In this conversation, veteran biohacker and BiOptimers co-founder Matt Gallant returns to the show with some straight talk about how to get more and better sleep. He’s spent the big bucks—about $50K he estimates—exploring, experimenting and upgrading his own sleep. He's sharing what he now knows so you can create a sleep stack that supercharges your own energy.
You’ll learn about the most common sleep disruptors and what to do about them. You’ll also learn to recognize sleep stages and how to improve your sleep pathways.
This fun show uncovers the practical sleep devices, wearables, supplements and lifestyle hacks that will lull you to sleep. So many times, you’re tired and you know you want to go to sleep—and yet—your body and mind just don’t connect. The new Sleep Breakthrough makes that connection for you. And when cortisol runs amok and falsely perks you up with a second wind, you’ll know what to do.
More and better sleep means you’ll be a higher-performing human. So, get some tonight!
SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://sleepbreakthrough.com/dave and use code DAVE10 to get an extra 10% off.
Watch this episode on YouTube!
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Cooler Temps for Deeper Sleep: https://www.chilisleep.com/, use code HUMANUPGRADE20 to save 20% on the Dock Pro Sleep System
Must-Have Magnesium: https://magbreakthrough.com/dave, use code DAVE10 to get a 10% discount
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Wired to Lead the Neobiological Revolution – Jane Metcalfe : 1025
The Human Upgrade with Dave Asprey
02/24/23 • 91 min
IN THIS EPISODE OF THE HUMAN UPGRADETM... the guest is one of the founders of Wired Magazine and someone who has been a continuous source of interest, news and data for decades, Jane Metcalfe. Having basically dissected nerds for her entire life, Jane now runs a fantastic newsletter and news site called NEO.LIFE where she writes about biohacking and the future. If you were to combine someone who really understands society and understands tech (and has read as much science fiction as possible) you would have Jane.
Jane’s, focus throughout her, career has been on how technology is transforming our world. But now she is fascinated with how deeply we can see inside the body and how processing the data we collect allows us to discover new cells, understand complex biological systems, and engineer bacteria, viruses, DNA, and ultimately ourselves.
Her new platform, NEO.LIFE is for exploring how we Homo sapiens will use these technologies and new understandings to power our own evolution.
Watch this episode on YouTube!
Get all the links and resources in the show notes.
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Get the week’s news and fresh ideas from the neobiological frontier. https://neo.life
Join us at the 9th Annual Biohacking Conference: https://biohackingconference.com
Dave Asprey’s NEW Book! “Smarter Not Harder: The Biohacker’s Guide to Getting the Body and Mind You Want” launches Feb. 28, 2023. Pre-order yours today: IndieBound / Barnes & Noble / Apple Books / Amazon
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How to STOP Living in Fear and Find Your Purpose in Life | Ryan Holiday : 1236
The Human Upgrade with Dave Asprey
12/26/24 • 75 min
Fear is quietly running your life—and it’s holding you back from the purpose and success you deserve. In this episode, we revisit Dave chatting with one of the keynote speakers for the Biohacking Conference 2025, Ryan Holiday, the bestselling author of Courage Is Calling, to tackle the one thing standing between you and your potential: fear.
Why should you listen? Because fear is the root cause of procrastination, self-doubt, and the endless excuses that keep you stuck. Ryan reveals why courage isn’t just about bravery—it’s about making the hard choices that align with your purpose, even when the stakes are high.
Drawing on powerful examples from history and modern life, Ryan explains how fear can be transformed into a catalyst for action and why embracing discomfort is the key to unlocking true freedom. If you’ve ever felt paralyzed by uncertainty, this episode will give you the tools and perspective to take control, face your fears, and create the life you’re meant to live.
Why This Episode Matters:
• You’ll discover how fear sneaks into your decisions—and how to stop it
• Learn why courage is the ultimate skill for success and fulfillment
• Get actionable advice to break through self-imposed limits
• Understand the psychology of fear and how to use it as fuel
• Hear real-life stories of people who overcame fear to achieve greatness
Resources:
2025 Biohacking Conference – https://biohackingconference.com/2025
Ryan Holiday’s Website – https://ryanholiday.net
Daily Stoic Website – https://dailystoic.com/
Ryan Holiday’s Book: Courage Is Calling – https://a.co/d/czEfCXC
Ryan Holiday’s Instagram – https://www.instagram.com/ryanholiday
Danger Coffee – https://dangercoffee.com
Dave Asprey’s Website – https://daveasprey.com
Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books
Dave Asprey’s Linktree – https://linktr.ee/daveasprey
Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com
Own an Upgrade Labs – https://ownanupgradelabs.com
Upgrade Labs – https://upgradelabs.com
40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com
Sponsors
-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.
-Pendulum | Go to https://pendulumlife.com/ and use code Asprey20 for your first month of GLP-1 or any Pendulum formula.
Timestamps:
• 00:00 – Intro
• 00:44 – Discussing Ryan Holiday’s Work
• 02:37 – The Concept of Courage
• 08:09 – Fear and Courage in History
• 12:41 – Stoic Philosophy and Modern Applications
• 21:50 – The Four Virtues and Their Interrelation
• 28:39 – Challenges in Admitting Mistakes
• 35:21 – Navigating Business Risks During a Pandemic
• 36:44 – The Essence of Courage in Business and Life
• 37:03 – Reed Hastings and the Duality of Courage
• 40:06 – Moral Courage: Lessons from History
• 43:35 – The Debate on Mandates and Personal Freedom
• 45:22 – Balancing Public Health and Individual Rights
• 58:29 ...
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The TRUTH About Vaccines for Kids (A Pediatrician Speaks Out on the Risks) | Joel "Gator" Warsh : 1238
The Human Upgrade with Dave Asprey
01/02/25 • 86 min
Are we protecting our kids—or unknowingly putting their health at risk?
Dr. Joel “Gator” Warsh isn’t just another pediatrician; he’s a bold voice speaking out on the vaccine debate that’s dividing parents, doctors, and society. In this episode, we pull back the curtain on one of the most censored and controversial topics of our time.
With his integrative and functional approach, Dr. Warsh unpacks the startling rise in chronic illnesses among children and questions if we’re truly asking the hard questions about vaccine safety and efficacy. This isn’t about taking sides—it’s about uncovering the truths every parent needs to know.
Dave and Dr. Warsh dive deep into the science, the myths, and the hidden risks Big Pharma doesn’t want you to hear about. Whether you’re a parent, a skeptic, or just someone seeking the truth, this episode will give you the tools and insights to navigate this complex issue with confidence.
What You’ll Learn:
• The alarming rise in chronic illnesses and what might be driving it
• Why vaccine safety studies may not tell the whole story
• The critical questions every parent should ask before vaccinating
• How toxins in our environment are impacting our kids’ health
• Practical steps to protect your children in today’s world
Resources:
• 2025 Biohacking Conference – https://biohackingconference.com/2025
• Dr. Joel “Gator” Warsh’s Book: Parenting at Your Child’s Pace – https://www.amazon.com/Parenting-Your-Childs-Pace-Pediatricians/dp/1454952490
• Dr. Joel “Gator” Warsh’s Website – https://www.integrativepediatrics.com
• Dr. Joel “Gator” Warsh on Instagram – https://www.instagram.com/drjoelgator
• Danger Coffee – https://dangercoffee.com
• Dave Asprey’s Website – https://daveasprey.com
• Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books
• Dave Asprey’s Linktree – https://linktr.ee/daveasprey
• Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com
• Own an Upgrade Labs – https://ownanupgradelabs.com
• Upgrade Labs – https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com
Sponsors:
-STEMREGEN | Head to https://www.stemregen.co/dave for 20% off your first order.
-BON CHARGE | Go to https://boncharge.com/ and use coupon code DAVE to save 15%.
Timestamps:
• 00:00 Intro
• 00:40 Personal Health Journey and Pediatric Concerns
• 01:41 Interview with Dr. Joel Gator Warsh
• 02:49 Rising Chronic Diseases in Children
• 04:03 Factors Contributing to Health Issues
• 10:13 Debating Vaccine Safety and Efficacy
• 30:32 Historical Context and Vaccine Research
• 44:18 Introduction to Dr. Joe Dispenza and Meditation
• 45:13 Genetics and Vaccine Controversies
• 46:16 The Importance of Individualized Medicine
• 49:02 Western Medicine’s Flaws and Alternatives
• 50:07 Childhood Health Crisis and Solutions
• 50:52 Pharmaceutical Industry Critique
•
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FAQ
How many episodes does The Human Upgrade with Dave Asprey have?
The Human Upgrade with Dave Asprey currently has 1328 episodes available.
What topics does The Human Upgrade with Dave Asprey cover?
The podcast is about Biohacking, Meditation, Health & Fitness, Nutrition, Lifestyle, Wellness, Hacking, Fitness, Podcasts, Self-Improvement, Education, Brain, Fat, Fasting and Diet.
What is the most popular episode on The Human Upgrade with Dave Asprey?
The episode title 'The Bacteria That Lets You Drink Alcohol Again – Zack Abbott, Ph.D. : 1000' is the most popular.
What is the average episode length on The Human Upgrade with Dave Asprey?
The average episode length on The Human Upgrade with Dave Asprey is 57 minutes.
How often are episodes of The Human Upgrade with Dave Asprey released?
Episodes of The Human Upgrade with Dave Asprey are typically released every 3 days.
When was the first episode of The Human Upgrade with Dave Asprey?
The first episode of The Human Upgrade with Dave Asprey was released on Aug 29, 2011.
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