The Human Upgrade with Dave Asprey
Dave Asprey
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For a decade, Dave Asprey, “the father of biohacking,” elevated what you knew about the capabilities of your mind and body across a thousand episodes of Bulletproof Radio. Now, he’s evolving it even further in his plan to upgrade humanity. You’re invited to expand your knowledge, explore your own performance and embrace possibility with The Human UpgradeTM.
You’ll meet bright thinkers and radical doers who push the boundaries of science, technology, personal development, and human performance in every way imaginable. You’ll learn from experts around the world who elevate what it means to be human.
Every guest you listen to, every topic you learn about, every new idea you discover on this podcast moves you forward.
Join The Human UpgradeTM with Dave Asprey on this next evolution to upgrade your mind, body and life.



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Upgrade Spotlight: How to Fight Zombie Cells and Win Aging – Neurohacker Collective : 1009
The Human Upgrade with Dave Asprey
01/07/23 • 32 min
Neurohacker Collective sponsored this episode.
IN THIS "UPGRADE SPOTLIGHT" EPISODE OF THE HUMAN UPGRADETM... you’re going to learn about the zombie cells taking up valuable space in your body and how you can clear them out with senolytics.
When these zombie cells accumulate (formally called senescent cells), they negatively impact how you age. You may experience symptoms like joint discomfort, low mental and physical energy, poor metabolic health, and diminished muscular response when you work out.
Naturopathic physician Greg Kelly joins the show from Neurohacker Collective, where he’s director of Product Development. His expertise includes nootropics, anti-aging and regenerative medicine, weight management, sleep, and the chronobiology of performance and health.
The hallmarks of aging include nine characteristics that organisms all the way up to humans share as we age, Dr. Kelly explains. One of those characteristics is senescent cells.
This discussion gets into the reasons why senescence happens, the science of senolytics, exciting new research, and new product developments that help bodies naturally eliminate senescent cells. This means a better aging process for you!
SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Go to https://neurohacker.com/dave and code ASPREY to get an additional 15% off. You can trial Qualia Senolytic for up to 100 days with a full 100% money-back guarantee.
Watch this episode on YouTube!
9th Annual Biohacking Conference: Come join like-minded people June 22-24 in Orlando, Florida, for three days of awesome! You’ll learn from dozens of experts at an amazing event that’s designed to upgrade every area of your life. https://biohackingconference.com
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01/07/23 • 32 min


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How to Eat Smarter and Trigger Your Metabolic Switches – Shawn Stevenson : 983
The Human Upgrade with Dave Asprey
10/04/22 • 54 min
IN THIS EPISODE OF THE HUMAN UPGRADETM... you’ll learn how you can make smarter food choices to support your metabolic energy and upgrade your brain. You’ll also find out some new things about body fat. For example, did you know that it’s a complex organ that communicates throughout your entire body system? You’ll get tips on fat loss essentials and how to use them to your advantage.
Today’s guest, Shawn Stevenson, hosts a popular podcast called The Model Health Show. He’s a nutritionist, researcher and bestselling author with education and experience in business, biology, and nutritional science.
Shawn’s been in the health and wellness space and doing clinical work as a nutritionist for nearly two decades. He’s known for his ability to keep learning and evolving his approach with deep research into the science of human health.
He’s all about improving human performance and energy with science-backed basics like food in his “Eat Smarter” book and sleep in his “Sleep Smarter“ book.
This episode gets right into food choices you can make—and why they work—to stoke your metabolic energy. Topics like:
- How people can better understand the process of fat loss.
- How the misconstrued science of calories contributes to how much people struggle with their diets.
- What metabolic switches are, what do they do, and why it’s important for you to know how to turn them on and off.
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10/04/22 • 54 min

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You’re Actually Not a Badass and Here’s Why – Scott Barry Kaufman, Ph.D., with Dave Asprey : 775
The Human Upgrade with Dave Asprey
12/22/20 • 61 min
In this episode of Bulletproof Radio, my guest, Scott Barry Kaufman, Ph.D., is a humanistic psychologist exploring the depths of human potential. We go way beyond basic needs and discuss how to get close to transcendence. Hint: you get to change (or even drop) the story you tell about yourself. It’s one of the hard parts of self-actualization, but worth it to move your life forward.
When Scott discovered Abraham Maslow's unfinished theory of transcendence through unpublished journals, lectures and essays, he felt a deep connection to his own work. Maslow is most famous for his theory on the hierarchy of needs
“We can harness [Maslow’s theory of] transcendence in our lives and we can be motivated by what he called the B values, the values of pure being, the values in life that you don't engage with and you're not one with because you want something else,” Scott says.
Scott’s curiosity led him to finish Maslow’s theory and update it with seven decades of new science that’s been discovered since. The result is Scott’s new book, “Transcend: The New Science of Self-Actualization.”
I took Scott’s free self-actualization test, and we explore my results in today’s discussion. Scott has great insights about how to approach vulnerability with yourself and others, self-awareness, attachment and other critical pieces of human growth and personal development.
“A lot of people don't realize that they can actually divorce their mind and have a lot more psychological free will,” he says. “Sometimes I think it's an act of craziness to exert it.”
Scott unravels the mysteries of Maslow’s unfinished theory and integrates these ideas with the latest research on connection, creativity, love, purpose and other building blocks of a life well lived, and gives science-backed suggestions, including:
- Fight familiarization and seek fresh experiences.
- Periodically get away from time-and-space concerns.
- Get out of the “deficiency realm” by deliberately going to the “being realm.”
“These aren't necessarily things that are going to make you happy,” Scott says. “Again, we're going through the difference between happiness and growth, but they're things that will help you grow. They really will. They'll help you get outside your comfort zone.”
Scott has been named one of "50 Groundbreaking Scientists who are changing the way we see the world" by Business Insider. He’s hosted “The Psychology Podcast” since 2014 and wrote the popular “Beautiful Minds” blog for Scientific American for close to a decade.
Enjoy! And get more resources at https://blog.daveasprey.com/category/podcasts/
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12/22/20 • 61 min

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Mini-Episode: Cool Facts Friday #19
The Human Upgrade with Dave Asprey
01/28/22 • 16 min
Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.
- 3 things indicate whether you’ll look for information or remain ignorant
- Deadly anthrax toxin could be a new pain reliever
- Multiple break-ups and solitary living linked to inflammation in men
- Insects may be the next big thing in animal protein alternatives
- Nerve cells in the brain suppress reproductive hormones when cortisol is too high
- Stress before and during pregnancy alters infants' cellular aging
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01/28/22 • 16 min

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How to Double Your Energy – Ari Whitten : 934
The Human Upgrade with Dave Asprey
05/06/22 • 61 min
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IN THIS EPISODE OF THE HUMAN UPGRADETM...
...you’ll find out why you’re tired, how to fix it and ways to increase your energy. Fatigue is a hidden epidemic, with chronic fatigue syndrome being the most severe end, but most people (in the U.S.) are experiencing some level of being flat-out tired as hell.
Guest Ari Whitten, Ph.D. (Cand.), CES, PES, says that as a culture, we have normalized fatigue. In his newest book, “EAT FOR ENERGY: How to Beat Fatigue, Supercharge Your Mitochondria, and Unlock All-Day Energy,” he explains that 5.4 million adults in the U.S. have been diagnosed with chronic fatigue syndrome (the most severe case of fatigue). However, the true fatigue epidemic affects 50 to 100 times more people.
This episode’s discussion gets right into the role of mitochondria in human energy. Ari’s research (420 citations in “Eat for Energy”!] is clear. The cause of fatigue is mitochondrial dysfunction, he says. And the biggest factors that affect your mitochondria include:
- Circadian rhythm dysregulation and poor sleep
- Carrying too much body fat and too little muscle mass
- Poor gut and microbiome health
- Blood sugar dysregulation
- Nutritional toxicities and deficiencies
- Neurotransmitter and hormone imbalances
So what can you do to increase your energy currency? A lot, as it turns out. When you understand factors like resilience, cell defense, nutrition and supplementation, you’re on your way to better energy. In this conversation, you’ll learn:
- what’s causing the dysfunction in your mitochondria and how you can repair these critical energy cells.
- strategies that will double your energy levels.
- 7 top supplements (and more) that help get your mitochondria back on the energy track.
Ari has been studying and teaching natural health science for more than 25 years. He went through his own battle with chronic fatigue that inspired his obsession with energy. For the past seven years, he's focused specifically on improving human energy. His education and work in this area touches on critical aspects of human health from nutrition to physical training, to light science, to psychology, and more.
He created The Energy Blueprint science-based lifestyle programs that target brain energy and mitochondria. He also hosts The Energy Blueprint podcast that features world-wide experts on the subject of understanding fatigue and how to get more energy.
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05/06/22 • 61 min

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Nillion Gives Crypto & Data Security a Human Upgrade – Conrad Whelan : 971
The Human Upgrade with Dave Asprey
08/25/22 • 47 min
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Dave Asprey partners with Nillion as an advisor and investor.
IN THIS EPISODE OF THE HUMAN UPGRADETM...
... you’ll learn about the frontier of web3 and privacy and what happens to your private data (both on blockchains and in general). You’ll also find out how and why the future moves away from transactions (blockchain) and into computations (multi-party computation).
Think about where you store your identity and your deepest digital secrets. The current solutions aren’t great — in web2, the Big Tech 'old guard' has been quietly storing and monetizing your data for over a decade, and in web3, blockchains aren't designed to handle private data. A new algorithm, Nillion, inspired Conrad Whelan (the Founding Engineer of Uber) to come out of early retirement and do something about this.
This conversation looks at the data you unassumingly give away freely, and how it’s captured, held and used/computed on without your consent by large companies and other parties. Conrad believes in a future where your sensitive data and digital secrets can be fully controlled by you (and you alone) using web3 technology. This means you’d be the final gatekeeper of your data with the power to authenticate, authorize and use it as you see fit.
Conrad’s building that future as Nillion’s Founding Chief Technology Officer. His background includes electrical and computer engineering. He worked in the fields of computational electromagnetics before joining Uber as Founding Engineer. He’s developed, tested, deployed and architected software projects at all levels of the software stack as both an engineer and an engineering manager.
In 2016, he retired to focus his efforts on philanthropy and personal passion projects while keeping an eye on the tech world. The promise and potential global impact of Nillion enticed him out of retirement and into the company’s CTO role. What Conrad is building at Nillion aims to:
- render both computational encryption and centralized storage of private data obsolete;
- fundamentally change the way private data is stored and processed;
- offer alternative non-blockchain ways of using decentralized nodes;
- serve as a ‘Meta Layer’ that provides new and additional functionality to existing blockchains; and
- enable a host of new real-world applications on its native public network (the Nillion Network).
Whatever your level of tech understanding, this discussion offers critical insights about the next big move in decentralized computing and data privacy.
Find more info in the show notes on this episode's webpage: https://daveasprey.com/conrad-whelan-971/
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08/25/22 • 47 min

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How to Build Strength Faster – John Jaquish, Ph.D., with Dave Asprey, Part 2 : 863
The Human Upgrade with Dave Asprey
10/01/21 • 44 min
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In Part 1 of our two-part episode with John Jaquish, Ph.D., I talked with him about building bone density—an important factor in your strength and longevity. Don’t miss! Building Strength Isn’t About Weight Lifting Anymore – John Jaquish, Ph.D., with Dave Asprey, Part 1 – #862.
This inventor, author, and scientist created OsteoStrong and the X3 System, a series of devices that combine rehabilitation and advancements in human physiology to build bone density. His extensive research into bone density and strength found that you can approach weight lifting much differently than you may think.
“It appears that the most biological adaptation comes from not the area under the curve, the total volume of work you did, but has to do with how quickly did you go from zero to 100 and back to zero,” John says. “So, a very brief spike of almost anything causes way more adaptation than spiking up to 70% and holding it.”
Now in Part 2, our conversation dives into John’s other findings and lifestyle choices, both as a public figure, a mentor for professional athletes and a fasting enthusiast. We go off the beaten path on a few things:
- Anabolic rebound after fasting (what fasting does to build muscle mass)
- Tendon mutations (and how they make people outrageously strong)
- Taking Viagra (or other non-pharmaceuticals) and carbs to trigger a muscle cell splitting
- The difference between fructose, glucose and sucrose (is there any real difference in the body?)
We also talk about ways to eat for strength and the quest for longevity that guides him. He knows about the tempting danger of eating to only look good (but you feel like crap). He offers tips to make sure you don’t go there.
Check out John’s book to learn more: Weight Lifting Is a Waste of Time: So Is Cardio, and There’s a Better Way to Have the Body You Want
Enjoy! And get more resources at Dave.Asprey/podcasts. Got a comment, idea or question for the podcast? Submit via this form.
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10/01/21 • 44 min

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Mathematics of Consciousness -Your Life as a Video Game. Dr. Ted Achacoso : 495
The Human Upgrade with Dave Asprey
05/24/18 • 71 min
Dr. Ted Achacoso ... Possibly one of the smartest guys around ... on Health Optimization Medicine.
What's that you say? He ties together clinical Metabolomics, epigenetics, bioenergetics, your gut immune systems, artificial intelligence, chronobiology, evolutionary medicine, basically stuff you might have heard about if you listen to this show, and puts it all together.
In this episode of Bulletproof Radio, Dave Asprey and Dr. Achacoso go from the outer reaches of space, to the inner workings of your cells, and wonder if it is all just a video game.
Enjoy the show!
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05/24/18 • 71 min

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Why Lying to Yourself Could be a Good Thing – Marisa Peer : 892
The Human Upgrade with Dave Asprey
01/14/22 • 61 min
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IN THIS EPISODE OF THE HUMAN UPGRADETM...
...you’ll learn about a therapy method that gets to the root of your problem and solves it within one to three sessions.
“The main reason it works, I believe, is that it overcomes the high level of resistance that most people have to changing fundamental beliefs about themselves by getting to the deepest core of their belief very quickly,” says Marisa Peer.
Marisa is a clinical psychologist and expert in human behavior who developed a new way to approach your mental health — Rapid Transformational Therapy® (RTT®). RTT offers the same benefits of traditional therapy, but on a much quicker timeline.
“I didn't understand why therapy, which is also dealing with pain, had to be so long. I never got that ‘turn up with your pain every week,’” she says. “We'll keep reopening the wound. And one day, you might get better.”
She’s also an international best-selling author of multiple books, motivational speaker, personal development expert and leading celebrity therapist. She’s worked with people around the world and most of them have a story they tell themselves about not being “enough.” Her newest book puts the focus squarely on the personal narrative you’re clinging to: “Tell Yourself A Better Lie: Use The Power Of Rapid Transformational Therapy To Edit Your Story And Rewrite Your Life.”
“After 30 years of private practice, I created Rapid Transformational Therapy (RTT) because it was clear to me that so much of the pain and suffering we see in the world comes down to the fundamental stories we tell ourselves and how often those stories are untrue or outright lies,” she explains. RTT has roots in hypnosis.
Marisa helps people pinpoint the reasons behind why people want what they want, so they can actualize a meaningful life for themselves. She uses a solution-oriented technique that can make you mentally stronger, more confident and even more loving towards yourself.
“He who hesitates is lost,” she says. “While you're waiting to write your book or start your company, someone else is going to come along and write that book and start that company. So, time is the one thing we don't have access of. And so, I think they'll always be people who like that long method [of traditional talk therapy] and a lot of people who don't like it. And I think we can definitely accommodate both.”
It’s time to start telling yourself the truth about who you are. “Our greatest pain is caused by the lies we tell ourselves,” Marisa says. She offers candid advice on how to help you recognize the harmful story you tell yourself and how to change it to a better one.
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01/14/22 • 61 min

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Longevity Strategies To Use Right Now – Tony Robbins & Peter Diamandis, M.D. : 905
The Human Upgrade with Dave Asprey
02/15/22 • 67 min
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IN THIS EPISODE OF THE HUMAN UPGRADETM...
...Tony Robbins and Peter Diamandis, M.D., distill the knowledge, expertise and life’s work of more than 100 doctors, scientists, and Nobel Laureates. The world’s top experts in medicine, technology, and science show you what’s available right now. This means you can gain access to the tools that turn back your biological clock.
Tony is an entrepreneur, best-selling author, philanthropist, and the nation’s No. 1 life and business strategist.
Peter accelerates breakthroughs in products, companies, and industries to solve some of the world's greatest challenges. He’s a Harvard Medical School-trained doctor; founder and executive chairman of the XPRIZE Foundation; and executive founder of Singularity University.
I wanted to have them on the show together to talk about what’s new and next level in biohacking and the incredible advances happening in health technology. They teamed up to write the new book: “Life Force: How New Breakthroughs in Precision Medicine Can Transform the Quality of Your Life & Those You Love.”
The book lays out advancements in precision and regenerative medicine so you can increase your energy, improve your immune system, and extend the length and quality of your life.
Tony’s own personal health issues and use of stem cells led him into the topics in this book. In less than a year using many of the advances he writes about, Tony reduced his biological age from 62 to 51.
Coming in at nearly 700 pages, “Life Force” guides you through sections of easy-to-digest information and practical tips.
- The Life Force Revolution (how to make yourself the CEO of your own health)
- Heroes of the Regenerative Medicine Revolution (technologies changing every concept we think we understand about medicine)
- What You Can Do Now (ways to expand your physical and emotional energy)
- Tackling The Top 6 Killers (heart disease, stroke, cancer, inflammation and autoimmune disease, diabetes and obesity, Alzheimer’s disease)
- Longevity, Mindset & Fulfillment (exponential technologies driving longevity like genome sequencing, storage, computation and communications)
Through this compilation by Tony, Peter and Robert Hariri, M.D., Ph.D., you’ll find out about powerful resources for healing, transformation and regeneration of the human body. You’ll accelerate your learning, dial up your performance and put into motion innovative ways you can live a longer life.
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02/15/22 • 67 min

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FAQ
How many episodes does The Human Upgrade with Dave Asprey have?
The Human Upgrade with Dave Asprey currently has 1169 episodes available.
What topics does The Human Upgrade with Dave Asprey cover?
The podcast is about Biohacking, Meditation, Health & Fitness, Nutrition, Lifestyle, Wellness, Hacking, Fitness, Podcasts, Self-Improvement, Education, Brain, Fat and Diet.
What is the most popular episode on The Human Upgrade with Dave Asprey?
The episode title 'Upgrade Spotlight: How to Fight Zombie Cells and Win Aging – Neurohacker Collective : 1009' is the most popular.
What is the average episode length on The Human Upgrade with Dave Asprey?
The average episode length on The Human Upgrade with Dave Asprey is 56 minutes.
How often are episodes of The Human Upgrade with Dave Asprey released?
Episodes of The Human Upgrade with Dave Asprey are typically released every 3 days, 1 hour.
When was the first episode of The Human Upgrade with Dave Asprey?
The first episode of The Human Upgrade with Dave Asprey was released on Aug 29, 2011.
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