The Health Edge: translating the science of self-care
Mark Pettus MD and John Bagnulo PhD, MPH
“It’s not what we don’t know that gets us into trouble. It’s what we know that ain’t so”.
Will Rogers
We believe the explosion of life science research from many disciplines had catapulted ahead of our capacity to process, integrate, understand, and apply. We are interested in translating all that is out there as news to use. A fundamentally different understanding of human biology has emerged. The implications from the perspective of self-care are profound. We are rapidly moving away from the debate of nature versus nurture toward an understanding that life emerges from a dynamic landscape of nature via nurture.
We are passionate about the science. We are passionate about the implications. We believe in the capacity and possibility made possible by being alive here and now! We are beautifully designed to be on the African Savannah, living fully integrated with our planet, and in the context of social relationship. Our modern environment is not well designed to promote human health and the capacity to thrive. Many are struggling to maintain balance and traction in lives that often feel overwhelming and frightening.The challenge is to better leverage our superb ancestral adaptation for a different and radically challenging modern environment. Everything that touches us today has the potential be be very familiar or totally foreign. The less aware one is of the day to day distance between what we are biologically , as a species, “familiar with” and what we actually encounter, the fewer the possibilities for more effective alignment.
Leaving one’s health trajectory to chance in our modern environment is a very risky proposition. We are interested in holding the science to the light with an open and humbled mindset. Like you, We are intrepid explorers interested in how we emerge in the midst of our relationship with the environmental inputs of our lives...how we eat, how we move, how we sleep, how we navigate the mind fields of conflict in our lives, how socially connected we are, how we manage the burden of environmental toxins in our lives, how much meaning we cultivate in our work, love, play and how we interpret and respond to stress in our lives. We will drill deep, share all that my experiences has taught and do all that we can to create value for you as you seek to find your health edge. We always welcome your feedback.
Mark and John
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Top 10 The Health Edge: translating the science of self-care Episodes
Goodpods has curated a list of the 10 best The Health Edge: translating the science of self-care episodes, ranked by the number of listens and likes each episode have garnered from our listeners. If you are listening to The Health Edge: translating the science of self-care for the first time, there's no better place to start than with one of these standout episodes. If you are a fan of the show, vote for your favorite The Health Edge: translating the science of self-care episode by adding your comments to the episode page.
Playing with Fire: How Modern Lifestyle Fuels Inflammation
The Health Edge: translating the science of self-care
04/03/25 • 39 min
Chronic inflammation has emerged as one of the most significant drivers behind virtually all modern health challenges. In this thought-provoking exploration, Dr. Mark Pettus reveals why researchers now refer to inflammation as "the cause of everything" and introduces the concept of "inflammaging" – how chronic inflammation accelerates biological aging and compromises quality of life.
Dr. Pettus takes us beyond conventional medical thinking to understand that while inflammation is an essential protective mechanism, it becomes destructive when chronically activated. Our modern environment, filled with processed foods, chronic stress, environmental toxins, and disrupted sleep patterns, keeps this system perpetually triggered, setting the stage for everything from diabetes to autoimmune conditions.
The most eye-opening revelations come when Dr. Pettis challenges popular nutritional dogma. He explains why fat has been unfairly vilified while highlighting how the standard American diet—dominated by processed carbohydrates and industrial seed oils—creates the perfect inflammatory storm. You'll discover why quality animal proteins and fats may be critical anti-inflammatory allies while learning how to identify truly nutritious foods that align with your biology.
Beyond nutrition, you'll gain practical insights into creating a comprehensive anti-inflammatory lifestyle through improved sleep, stress management, movement, and perhaps most surprisingly, through cultivating self-love and meaningful connections. Dr. Pettus shares specific testing recommendations to objectively measure your inflammation levels and track your progress.
Whether you're dealing with chronic health challenges, carrying extra weight, struggling with energy levels, or simply want to optimize your health span, this presentation offers a refreshing perspective that empowers you to address root causes rather than merely managing symptoms. Take the first step toward creating an anti-inflammatory lifestyle by implementing these evidence-based strategies today.
For video recording and slide deck go to www.thehealthedgepodcast.com
For Essential Provisions Nutritional Meals Ready to Eat (MREs) go to www.essentialprovisions.com
Insulin Resistance: The Primary Driver of Modern Disease
The Health Edge: translating the science of self-care
01/04/24 • 53 min
In this Health Edge recording, Mark describes a model of integrative health-lifestyle medicine that is distinctly different from current allopathic disease-based models. He examines the metabolic perfect storm of insulin resistance and inflammation as passports to accelerated aging, chronic complex disease risk and poor quality of life or healthspan. His slides can be downloaded at www.thehealthedgepodcast.com
Statin Use, LDL Reduction and the Magnitude of Cardiovascular Benefit
The Health Edge: translating the science of self-care
12/27/23 • 30 min
In this episode of the Health Edge I review a recent meta-analysis examining the magnitude of cardiovascular benefit from taking statins for elevated LDL in both primary and secondary prevention.
JAMA Intern Med. 2022;182(5):474-481. doi:10.1001/jamainternmed.2022.0134 Published online March 14, 2022.
https://pubmed.ncbi.nlm.nih.gov/35285...
Exploring the Health Benefits of Saturated Fats and Full-Fat Dairy
The Health Edge: translating the science of self-care
12/05/23 • 41 min
Do you ever feel like everything you've been told about healthy eating seems to be teetering on the edge of being overturned? Welcome to a mind-bending exploration where we question the status quo, particularly the demonization of full fat dairy and saturated fats. I'm diving deep into a groundbreaking study suggesting that pentadecanoic acid, a saturated fat found in full-fat dairy could actually promote health and contribute to our longevity. We challenge the shortcomings in the traditional medical model and its ability to promote health, and ponder the rapid expansion of knowledge in the information age.
Our journey continues as we venture into another exciting discussion on the potential essential role that pentadecanoic acid plays in our bodies. A compelling study indicates that a deficiency of this saturated fat could contribute to chronic diseases. We're not trying to persuade you to change your dietary habits overnight, but rather, we invite you to question, learn, and make informed decisions about your health. As we wrap up, we highlight the importance of natural, whole foods in our diet and delve into how our modern lifestyle could be impacting our health. So, are you ready to embark on this journey into the world of saturated fats, dairy, and optimal health?
Red Meat and Diabetes: More than Meets the Eye
The Health Edge: translating the science of self-care
11/17/23 • 14 min
In a world where health advice is abundant, it can be challenging to sift through conflicting data and headlines. One such contentious issue is the connection between red meat and type 2 diabetes. On this episode of The Health Edge, we take a critical look at this connection and aim to provide a balanced perspective on this often polarizing topic.
The episode focuses on a recent study from the Harvard School of Public Health that has purportedly found a connection between red meat consumption and type 2 diabetes. This study suggests that red meat consumption increases the risk of diabetes by 62%. However, upon further scrutiny, we find that the absolute risk difference between meat-eaters and non-meat eaters is a mere 0.52% versus 0.37%. Furthermore, the study relies heavily on food frequency questionnaires, a method known to have numerous inherent flaws, thus raising questions about the study's overall impact.
The world of nutritional epidemiology is complex and fraught with potential pitfalls. One of the most significant issues is the use of confounding variables, factors that can interfere with the results of a study. For instance, when considering red meat consumption, how do we separate the impact of the meat itself from the other components often associated with it, such as high-fat sauces or refined grains? Additionally, inaccuracies in data collection methods, such as the use of food frequency questionnaires, can further muddy the waters.
These epidemiological studies are not without their merits, as they often provide hypotheses that merit further exploration. However, it's important to remember that quality nutritional research can be elusive. Therefore, the focus should not just be on what food one consumes, but also the overall nutrition and lifestyle factors.
To truly understand the implications of such studies, it is vital to consider the overall nutrition and lifestyle of an individual. A person's health is not just determined by their food choices but also their overall lifestyle. Factors such as physical activity levels, sleep patterns, stress levels, and even social determinants of health play a significant role in determining health outcomes. A hamburger consumed by a physically active person who maintains a balanced diet may not have the same health implications as the same hamburger consumed by a sedentary individual with a diet rich in processed foods.
In conclusion, while it is essential to remain informed about the latest nutritional research, it's equally important to approach these studies with a critical eye. While the connection between red meat and type 2 diabetes is a topic that continues to garner attention, it's clear that more comprehensive research is needed. The key takeaway is that your health is not solely determined by individual food choices but by a complex interplay of lifestyle factors. As always, the best approach is to maintain a balanced diet, stay active, and make informed decisions about your health.
For a thoughtful and more detailed review of this study and studies like this I highly recommend Zoe Harcombe's PhD terrific work. https://www.zoeharcombe.com/
Body Mass Index (BMI): Is it time to abandon this surrogate marker of metabolic health and mortality risk?
The Health Edge: translating the science of self-care
10/30/23 • 14 min
Ready to have your understanding of BMI flipped on its head? We're diving into an intriguing study that suggests a BMI lower than 25 might be linked with decreased mortality. That's right, what you've been told about the ideal BMI could be all wrong. We also tackle the waist to hip ratio, showing you how to measure it and why it might be a better health marker than BMI. So, grab a tape measure and prepare for a health knowledge overhaul.
Understanding the Complex World of Proteins, Essential Amino Acids, and the Role of IGF-1 in Brain Health
The Health Edge: translating the science of self-care
09/04/23 • 43 min
Are you ready to unlock the mysteries of protein and its pivotal role in our dietary intake? Strap in as we guide you through the complex world of essential amino acids, and the significant part they play in our bodies. We discuss the importance of achieving a balance in your protein consumption, focusing on the dietary reference intakes, and the potential risks of under-consuming protein. Discover why 25 grams of protein per meal can be beneficial for you, and the distinctions between plant and animal-based protein sources.
Unravel the potential of different essential amino acids and the exceptional benefits of branch chain amino acids found in dairy and egg products. Did you know they are crucial for muscle sparing? We explore this and more, including the importance of sulfur-containing amino acids, typically found in animal proteins, for detoxification and various physiological processes. Discover the vital collateral nutrients, like B12, Vitamin D, DHA, heme-iron, and zinc, found in animal food sources that are easily absorbed and more bioavailable in our systems.
Dive deeper into the world of IGF-1 and its significant role in brain health. We examine its importance for neurogenesis, cognitive preservation, anti-oxidant, and anti-inflammatory processes. Learn about the potential risks and benefits of controlling IGF-1 levels, including an increased risk of breast and prostate cancer, and its balancing act with insulin resistance. We also delve into the unique role branched chain amino acids play in stem cell development and brain health. Lastly, find out how strength training and exercise can influence IGF-1 binding proteins, and why this could be a game-changer for managing IGF-1. Join us in this enlightening conversation as we enhance your understanding of protein intake and sources.
Research Getting Our Attention
The Health Edge: translating the science of self-care
05/11/23 • 30 min
In this episode of the Health Edge Mark and John discuss areas of research they are closely following. John shares some interesting fatty acid research and introduces heptadecanoic acid as an emerging 17-carbon fat, important to healthy brain aging. Mark reviews some aging and longevity research he is following. Topics include epigenetic aging, biologic age regression using Yamanaka factors, gene and cell therapies, and senolytics.
Does excessive sodium restriction lead to insulin resistance?
The Health Edge: translating the science of self-care
04/21/23 • 35 min
In this episode of The Health Edge Mark and John review a recent paper drawing connections between excessive sodium restriction and insulin resistance. This adds to a growing body of research suggesting the restriction of sodium below 3-4 gms/day may in fact add to cardiometabolic risk. Current guidelines of 2300 mg/day or less fall well below these levels.
Creatine: The Underrated Powerhouse for Muscle and Brain Health
The Health Edge: translating the science of self-care
03/14/25 • 31 min
Creatine might be the most underappreciated nutritional powerhouse in our health toolkit. While many associate it exclusively with weightlifters and athletes, the science reveals a molecule with profound benefits reaching far beyond the gym.
Mark Pettus MD and John Bagnulo PhD,MPH dive into creatine's fundamental role in human physiology as part of our body's most immediate energy production system – the ATP-PCR pathway. They unpack how this simple compound supports not just muscle strength and lean body mass, but potentially shields against age-related decline in both physical and cognitive function.
The conversation dismantles persistent myths around creatine safety, clarifying why concerns about kidney damage and steroid-like effects are scientifically unfounded. Both hosts share their personal experiences and professional insights about optimal dosing (3-5 grams daily), sourcing (creatine monohydrate remains the gold standard), and why dietary sources alone (mostly red meat and small fish) often fall short of providing optimal levels – especially as we age and our natural creatine synthesis declines.
Perhaps most fascinating is the emerging research around creatine's role in brain health. Lower brain creatine levels correlate with neurodegenerative conditions like Alzheimer's, Parkinson's and ALS, suggesting that maintaining adequate creatine stores might help protect against cognitive decline through multiple mechanisms – from basic energy provision to antioxidant effects and enhanced dopamine recovery.
Whether you're an athlete seeking performance gains, someone focused on healthy aging, or simply exploring evidence-based supplements with remarkable safety profiles, this episode offers valuable insights into why creatine deserves consideration as part of your daily health regimen. Listen now to understand how this simple molecule might be working silently to protect your most metabolically active tissues – muscle and brain – throughout your lifetime.
Research studies referenced can be found at https://www,thehealthedgepodcast.com
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FAQ
How many episodes does The Health Edge: translating the science of self-care have?
The Health Edge: translating the science of self-care currently has 41 episodes available.
What topics does The Health Edge: translating the science of self-care cover?
The podcast is about Health & Fitness, Nutrition, Stress, Alternative Health, Medicine, Podcasts, Health and Microbiome.
What is the most popular episode on The Health Edge: translating the science of self-care?
The episode title 'Statin Use, LDL Reduction and the Magnitude of Cardiovascular Benefit' is the most popular.
What is the average episode length on The Health Edge: translating the science of self-care?
The average episode length on The Health Edge: translating the science of self-care is 41 minutes.
How often are episodes of The Health Edge: translating the science of self-care released?
Episodes of The Health Edge: translating the science of self-care are typically released every 13 days, 23 hours.
When was the first episode of The Health Edge: translating the science of self-care?
The first episode of The Health Edge: translating the science of self-care was released on Feb 11, 2021.
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