How CAR T cell therapy resulted in a complete remission in two subtypes of lymphoma

Marcus Humphrey, who was diagnosed with two subtypes of lymphoma in 2021, and his wife Mary Humphrey speak with Dr. Deborah Doroshow, an oncologist at the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai. Doroshow, who is also a historian of medicine, is a member of the editorial board of the Cancer History Project and is guest editor during National Cancer Survivor Month this June.

Humphrey sought treatment at Medical University of South Carolina Hollings Cancer Center for a swelling that had grown exponentially on the right side of his neck. Two regimens of chemotherapy failed. Marcus Humphrey’s oncologist later said it was the worst case of lymphoma he had ever seen.

Humphrey was almost out of options—and his heavy tumor burden made doctors wary of CAR T-cell therapy. They weighed the risks and went for it.

After receiving treatment with CAR T cell therapy, and managing the side effects of neurotoxicity, cytokine release syndrome, and mobility issues—Humphrey’s scans are clear. He’s vacationing in Italy now, and was overlooking the Adriatic sea with his wife Mary during this conversation, available on the Cancer History Project.