Top Cardiology Trials of 2021

Drs Harrington and Gibson provide their annual roundup of what they consider the key cardiovascular trials of 2021. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit

This podcast is intended for US healthcare professionals only.

To read a full transcript of this episode or to comment please visit:

https://www.medscape.com/viewarticle/963475

https://www.medscape.com/author/bob-harrington

Antiplatelet Therapy

Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease

https://doi.org/10.1056/NEJMoa2102137

Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk

https://doi.org/10.1056/NEJMoa2108749

Effect of 1-Month Dual Antiplatelet Therapy Followed by Clopidogrel vs 12-Month Dual Antiplatelet Therapy on Cardiovascular and Bleeding Events in Patients Receiving PCI

https://doi.org/10.1001/jama.2019.8145

Aspirin Versus Clopidogrel for Chronic Maintenance Monotherapy After Percutaneous Coronary Intervention (HOST-EXAM): An Investigator-Initiated, Prospective, Randomised, Open-Label, Multicentre Trial

https://doi.org/10.1016/S0140-6736(21)01063-1

SGLT2 Inhibitors and GLP-1 Agonists

Empagliflozin in Heart Failure with a Preserved Ejection Fraction

https://www.nejm.org/doi/full/10.1056/NEJMoa2107038

Once-Weekly Semaglutide in Adults with Overweight or Obesity

https://www.nejm.org/doi/full/10.1056/NEJMoa2032183

Cardiac Surgery and PCI

Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke

https://doi.org/10.1056/NEJMoa2101897

Concomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation

https://doi.org/10.1056/NEJMoa2115961

Fractional Flow Reserve–Guided PCI as Compared with Coronary Bypass Surgery

https://doi.org/10.1056/NEJMoa2112299

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