🧬 Rabia Khan - Serna Bio: Bridging Science & Tech—PhDs, MBAs, & Biotech Innovation (Part 2/4)

04/17/25 • 45 min

🧬 The Biotech Startups Podcast is powered by Excedr —helping life science startups accelerate R&D and commercialization with founder-friendly equipment leasing. Skip the upfront costs, stay lean, and focus on breakthrough science.As a TBSP listener, you can get exclusive perks through Excedr’s partner network—special savings, promotions, and more. Explore these offers today: https://www.excedr.com/partners.“I wish someone had told me when I was starting my PhD to sit down and say, ‘what do I want out of this?’ and [then] write it down. Because, unlike the UK, where PhDs are three years and time bound, in Canada, they are neither time bound nor three years. And so you can meander."

In this episode of The Biotech Startups Podcast, Rabia Khan, founder and CEO of Serna Bio, joins host Jon Chee to reflect on her unconventional journey through academia, business, and biotech innovation. Rabia shares how her curiosity, resilience, and embracing uncertainty shaped her journey through a PhD in genetics and an MBA. She discusses the emotional challenges of working with animal models, the benefits and limits of business school for scientists, and personal struggles, including her father’s illness.She recounts early setbacks, like rejected consulting jobs, and how a cold email landed her at Meta (now part of Chan Zuckerberg Biohub). Rabia emphasizes “manufacturing serendipity,” differences between founder and employee mindsets, and lessons from her work at BenevolentAI, highlighting the importance of cross-disciplinary communication and challenging industry norms.Key topics covered:

PhD Realities: Tackling emotional and practical research challenges
Dual-Degree Insights: Balancing PhD and MBA, knowing business limits
Personal Adversity: Turning family illness into resilience
Career Breakthroughs: Creating and seizing biotech startup chances
Bridging Disciplines: Fusing biology and ML to expand drug targets

If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening.Subscribe to the Podcast:Apple: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994Spotify: https://open.spotify.com/show/2PSL162R2s0zOwU5913Zv4Youtube: https://www.youtube.com/@thebiotechstartupspodcast Website: https://www.thebiotechstartupspodcast.com/ Find our guest, Rabia Khan, at these links: LinkedIn: https://www.linkedin.com/in/rabiatkhan/ Website: https://www.serna.bio/ Find our host, Jon Chee, at these links: LinkedIn: https://www.linkedin.com/in/joncheeLearn more about Excedr:LinkedIn: https://www.linkedin.com/company/excedr/ Website: https://www.excedr.comIntro & Outro Songs Created by OkKyojin, Owned by Excedr:Website: https://flow.page/kyojin Resources & Articles:Case in Point (book): https://caseinterview.com/case-in-pointSWOT Analysis: https://en.wikipedia.org/wiki/SWOT_analysisCRISPR Technology: https://www.genome.gov/genetics-glossary/CRISPRiPSC (Induced Pluripotent Stem Cells): https://en.wikipedia.org/wiki/Induced_pluripotent_stem_cellGWAS (Genome-Wide Association Studies): https://www.nature.com/articles/s43586-021-00056-9Ensembl: https://www.ensembl.org/index.html The concept of the “druggable genome”: https://www.frontiersin.org/journals/bioinformatics/articles/10.3389/fbinf.2022.958378/fullCompanies, Universities, & People mentioned:Francis Crick Institute: https://www.crick.ac.uk/BenevolentAI: https://www.benevolent.com/Meta (Acquired by Ch...

PhD Realities: Tackling emotional and practical research challenges
Dual-Degree Insights: Balancing PhD and MBA, knowing business limits
Personal Adversity: Turning family illness into resilience
Career Breakthroughs: Creating and seizing biotech startup chances
Bridging Disciplines: Fusing biology and ML to expand drug targets

Previous Episode

🧬 Rabia Khan - Serna Bio: Unraveling the Genetics of AI-Driven Drug Discovery (Part 1/4)

🧬 The Biotech Startups Podcast is powered by Excedr —helping life science startups accelerate R&D and commercialization with founder-friendly equipment leasing. Skip the upfront costs, stay lean, and focus on breakthrough science.As a TBSP listener, you can get exclusive perks through Excedr’s partner network—special savings, promotions, and more. Explore these offers today: https://www.excedr.com/partners."I was born and raised in a developing country. I was born and raised in Pakistan. And it's very interesting when you're born in a developing country. That's your world. Right? That's all you know."In this episode of The Biotech Startups Podcast, we delve into Rabia Khan's remarkable journey from her childhood in Pakistan to founding Serna Bio, an AI-enabled drug discovery company. Rabia shares how her early experiences in a developing country, her aunt's battle with schizophrenia, and the sequencing of the human genome in 2000 sparked her passion for genetics and healthcare. She recounts how her career options were either medicine or engineering, setting her on a path that would eventually lead to pioneering work at the intersection of AI and biotechnology.Rabia describes her transition to McGill University in Montreal, facing the shock of -40°C weather with only a leather jacket while navigating life as an international student with no support system. Despite these challenges, she pursued dual interests in biology and economics, finding her first research opportunity in a schizophrenia lab where she started by pipetting water and washing dishes. Key topics covered:

Formative Influences: Shaped by Pakistan upbringing, aunt's schizophrenia, and genome sequencing
Educational Journey: Balancing biology and economics at McGill
First Research Experiences: From lab basics to discovering a disease-causing gene
Decision-Making Frameworks: Applying economics principles to business decisions
Family Influence: Mother's practicality and father's entrepreneurial drive guided her path

If you enjoy The Biotech Startups Podcast, please consider subscribing, leaving a review, or sharing it with your friends. Thanks for listening.Subscribe to the Podcast:Apple: https://podcasts.apple.com/us/podcast/the-biotech-startups-podcast/id1679591994Spotify: https://open.spotify.com/show/2PSL162R2s0zOwU5913Zv4Youtube: https://www.youtube.com/@thebiotechstartupspodcast Website: https://www.thebiotechstartupspodcast.com/ Find our guest, Rabia Khan, at these links: LinkedIn: https://www.linkedin.com/in/rabiatkhan/ Website: https://www.serna.bio/ Find our host, Jon Chee, at these links: LinkedIn: https://www.linkedin.com/in/joncheeLearn more about Excedr:LinkedIn: https://www.linkedin.com/company/excedr/ Website: https://www.excedr.comIntro & Outro Songs Created by OkKyojin, Owned by Excedr:Website: https://flow.page/kyojin Resources & Articles:The Human Genome Project https://www.genome.gov/human-genome-project Schizophrenia https://en.wikipedia.org/wiki/Schizophrenia Opportunity Cost https://www.investopedia.com/terms/o/opportunitycost.asp Marginal Utility https://www.investopedia.com/terms/m/marginalutility.asp The Prisoner's Dilemma https://en.wikipedia.org/wiki/Prisoner%27s_dilemma Ray Dalio's Decision Making Frameworks https://www.principles.com/principles/7df5502f-46e5-47d5-8fd7-8fc70843b726/ Nassim Taleb's Antifragility https://en.wikipedia.org/wiki/Antifragile_(book) Black Swan by Nassim Taleb https://en.wikipedia.org/wiki/The_Black_Swan:_The_Impact_of_the_Highly_Improbable...

Next Episode

🧬 Sales Skills & Resilience: Hidden Drivers of Biotech Success | Rabia Khan (Part 3/4)

🧬 The Biotech Startups Podcast is powered by Excedr —helping life science startups accelerate R&D and commercialization with founder-friendly equipment leasing. Skip the upfront costs, stay lean, and focus on breakthrough science.As a TBSP listener, you can get exclusive perks through Excedr’s partner network—special savings, promotions, and more. Explore these offers today: https://www.excedr.com/partners."You have to be curious. You have to enjoy the problems as opposed to view them as problems. You can view them as puzzle pieces that you get to put together, which is a lot of fun."

In this episode of The Biotech Startups Podcast, Rabia Khan shares the pivotal experiences that shaped her approach to biotech innovation, from her time at BenevolentAI and Sensyne Health to building and leading high-performance teams at the intersection of biology, machine learning, and clinical data. Rabia discusses the challenges of aligning scientists and engineers around a shared language, the importance of integrating platform and program development, and the cultural shifts needed to drive real innovation in drug discovery. She also reflects on the value of curiosity, risk-taking, and the lessons learned from managing major pharma partnerships and scaling teams under intense pressure.Key topics covered:

Bridging Biology & Machine Learning: Breaking barriers to spark drug discovery innovation.
Platform vs. Program Development: Integrate or stagnate—unite teams to win in biotech.
Building & Leading Teams: Scaling fast and thriving in high-stakes pharma.
The Power of Curiosity & Risk-Taking: Question, risk, and grow—breakthroughs follow.
Sales & Resilience in Biotech: Master selling and stay tough to succeed in science.