Skin and Joints Podcast

🎙 Amsterdam Stories, Delta Force & A Game-Changing Topical for Chronic Hand Eczema

🎉✨ Melinda Knows Best is BACK! 🚀💥

This time, Dr. Gooderham brings us a heavyweight showdown 🥊 between a new topical superhero 🦸‍♀️ and the reigning oral champ 💊 in the battle against Chronic Hand Eczema! reporting live from the European Academy of Dermatology and Venereology (EADV) Congress in the beautiful city of Amsterdam! 🇳🇱✨

In this special episode, we’re diving into the Delta Force Trial – a bold study comparing topical delgocitinib to oral alitretinoin for chronic hand eczema 💊🧴

👀 Dr. Gooderham spills the beans on impressive results, rapid relief, and how this new treatment is about to change the game for dermatologists and patients alike. 🎉

Oh, and don’t worry, we didn’t forget to ask about her Amsterdam adventures! 🌍 Did she run into some famous faces at dinner? 🍽️👀 Tune in for the scoop!

💡 Melinda Knows Best will keep you at the cutting edge of CHE breakthroughs. 👩‍⚕️✨

🎯 Learning Objectives:

1. Explore the Delta Force Trial Findings: Understand the significance of the Delta Force trial comparing topical delgocitinib to oral alitretinoin for chronic hand eczema. 🧴💊
2. Evaluate the Efficacy of Topicals vs Orals for chronic hand eczema: Learn about the early onset of symptom relief with delgocitinib, including i reductions in HEXI scores and patient quality of life improvements. ⏱️📉
3. Identify Key Real-World Implications: Discuss how this new topical treatment can shift the landscape for clinicians and patients, offering rapid, safe relief without the headaches (literally!) of oral therapies. 💡
4. Dive into secondary endpoints, including itch and pain relief, and how this data compares to other major clinical trials in hand eczema treatment. 📊🔬

ABOUT Dr.Melinda Gooderham, MD, FRCPC ( Dermatology)

Toronto, ON

Melinda Gooderham MD MSc FRCPC Dr. Gooderham is a Dermatologist and Medical Director at the SKiN Centre for Dermatology and an Investigator with Probity Medical Research. She is an Assistant Professor at Queens University and a Consultant Physician at the Peterborough Regional Health Centre. She is a fellow of the Royal College of Physicians and Surgeons of Canada.

Dr. Gooderham has been the principal investigator for over 200 clinical trials and she practices with a focus on inflammatory diseases of the skin. She also contributes to several peer-reviewed dermatology publications as an associate editor, reviewer, and has been an author of 205 articles. She enjoys lecturing to global audiences on new therapies for skin diseases.

📻www.skinandjoints.ca

✉️[email protected]

📻www.skinandjoints.ca

✉️[email protected]

Hold onto your antioxidants—this episode of the podcast is a full-court press on free radicals!

When it comes to the science of antioxidants and topical formulations, we have the right person-dermatologist Dr. Mark Lupin debuts as a faculty expert on the podcast to practically decipher what you NEED to know

Also debuting on the podcast, but as a guest co-host, is dermatologist Dr. Vincent Richer who's ready to fire up the hot seat with pharmacist Aaron Sihota to ask the tough questions.

Don’t miss our RAPID FIRE round where we break down must-know ingredients faster than you can say ‘free radical!’ 🚀🦸

We dust off your old sunscreen routine and show you why slathering on antioxidants might just be your skin’s new secret weapon. Tune in for a fast-paced conversation that hops effortlessly from clinic chairs to concert halls, apples to ferulic acid, and vitamin C to conjugated retinol. Here, myths get busted, fancy science terms get decoded, and you’ll finally learn the ABCs of a top-tier skincare regimen—no sunscreen-shy patients or lost winter gloves required. ☀️🧴🍏

Trust us, this episode is your on-demand playbook reference for practice! 🎧📖

Learning Objectives:

1. Antioxidant Fundamentals: Understand how environmental aggressors cause oxidative stress on the skin and how antioxidants serve as powerful defenders. The latest science on how these mighty molecules supercharge your broad-spectrum sunscreen and reduce UV-induced damage?🌞🔬 ‍🍃
2. Key Ingredients in formulations: Identify evidence-based antioxidant ingredients, learn why they’re paired together, and explore optimal formulation concentrations and pH levels for maximum skin benefits. 🍏🔬
3. Critical Evaluation of Research: Gain tools and strategies to discern credible studies from marketing fluff, ensuring more informed clinical recommendations. 📚🔎
4. Integration into Practice: Discover practical tips for incorporating antioxidants into morning routines, combining them effectively with sunscreens, and managing patient expectations. ⏰✔️
5. Future Directions in Dermatology: Explore the promising frontier of antioxidant research, including their potential to complement medical interventions and the call for standardized validation measures. 🔭🚀

Get ready for an antioxidant masterclass 🤓✨— that’ll have you completely rethinking your recommendations!

ABOUT DR.MARK LUPIN MD FRCPC DABD

VICTORIA, BC

Dr. Lupin is a Board-certified Dermatologist, Founder in 1998 of Cosmedica Laser Centre in Victoria, British Columbia and Chief Clinical Officer of MedSpa Partners Inc.He has degrees in Mathematics, Music and Medicine having studied at the University of Toronto, University of British Columbia, Dalhousie University, Indiana University and the University of Southern California. He has special interests in photodermatology and laser medicine, having studied under Professor John Hawk at St John’s Institute of Dermatology, London, England. He is active with research and education, has additional subspecialty training in Neurology and is past President of the Canadian Laser Aesthetic Surgery Society.

As a concert violinist, Dr Lupin has performed as soloist at Carnegie Hall, New York and with major orchestras around the world. He is Concertmaster of the World Doctors Orchestra (WDO), performing most recently in Australia at the Sydney Opera House, with all proceeds donated to charities. His research interests extend to space medicine and fluid dynamics where he has been active with mathematical modeling for space tools and has developed several patent pending energy efficient devices.

ABOUT Dr. Vincent Richer MD FRCPC

VANCOUVER, BC

Dr Vincent Richer practices cosmetic dermatology at Pacific Derm Atelier in Vancouver and holds a position as Clinical Assistant Professor at the University of British Columbia’s Department of Dermatology and Skin Science. He trained at Université de Montréal in Medicine and Dermatology and completed a fellowship in Photobiology and Cutaneous Laser Surgery at UBC. He is involved as a subinvestigator in cosmetic clinical trials, has published 35+ peer reviewed scientific articles and is active in undergraduate, graduate and continuing medical education.

EPISODE SUPPORTED BY SKINCEUTICALS AND SKINBETTER SCIENCE.

📻www.skinandjoints.ca

✉️[email protected]

📻www.skinandjoints.ca

✉️[email protected]

🎙️🍫 Our Convo with Dr.Jerry TAN on Acne, Sun, Shades of Brown, and Identity 🌞🎨

🎙✈️ From a surprise detour in Toronto to runway rendezvous at the world’s best shopping airport. Join us for Dr. Jerry Tan’s deep dive into what's new in the world of acne

🌍✨Skin and Joints Podcast Dermatologist expert Dr.Jerry Tan untangles the intricate threads of identity. What do we say when someone asks about our ethnicity or race in an ever-mixed global landscape??🎨 Sick of the phototype jargon? Dive into a refreshing conversation where we shift from shades of grey to exploring every shade of brown 🎨

🌞🧴 And yes, don’t forget your sunscreen, no matter your shade!

#SkinAndJointsPodcast #WorldCongressOfDermatology #ShadesOfBrown #BeyondLabels #SunProtectionForAll

P.S. Spoiler Alert: Jet engines might be involved. 📍✈️😉

EPISODE Supported by BAUSCH HEALTH.

About Dr. Jerry Tan

Dermatologist, Windsor, ON

Dr. Tan received his medical degree from Queen’s University in Kingston, Ontario and trained in internal medicine at the University of Toronto and in dermatology at University of British Columbia and University of Michigan. His general dermatology and aesthetic dermatology practices are in Windsor Ontario Canada. He conducts clinical trials research at Windsor Clinical Research, a clinical trials site in dermatology. Aside from industry grants, he has received research funding from the Canadian Dermatology Foundation and the National Institutes of Health Research.

Research focus includes acne, acne scars and rosacea. Additional interests include outcome measurements and informed shared decision making in dermatology.

Dr. Tan chairs the working group on clinical practice guidelines of the Canadian Dermatology Association, the rosacea international consensus group (ROSCO) and the acne core outcomes research network (ACORN). He has been an associate editor of the Journal of the American Academy of Dermatology and the British Journal of Dermatology. Over the past 3 decades, Dr. Tan has authored/co-authored more than 100 peer-reviewed publications.

📻www.skinandjoints.ca

✉️[email protected]

📻www.skinandjoints.ca

✉️[email protected]

🔍Welcome back to Part 2 of our dialogue with Skin and Joint Podcast EADV Ambassador, Dr.Melinda Gooderham, where we delve deep into the groundbreaking advancements in treating chronic hand eczema, featuring the innovative pivotal trials and their implications for care.
Are we entering a new era for care for our patients with chronic hand eczema?

Making her guest hosting debut on the Podcast, Dr. Jessica Asgarpour joins us for PART 2.

🆕Key Highlights we take a look at in PART 2:

Exploring New Agents in Chronic Hand Eczema Treatment (Efficacy Perspectives and Quality of Life Measures):

• Dr. Gooderham offers an in-depth analysis of delgocitinib cream, a new topical for CHE.
• Delta 1 and Delta 2 trials focus on efficacy and safety
  • Outcomes in terms of the Hand Eczema Area and Severity Index (HEXI) and DLQI scores.

Safety Profile of Topical JAK inhibitors:

• Patient Adherence and Formulation Challenges
• The role of delgocitinib as a non-steroidal option in treating hand eczema.
• Discussion on the evolving landscape of dermatological treatments and patient access to new therapies
  

Episode supported by an IME Grant from LEO Pharma

ABOUT Dr.Melinda Gooderham, MD, FRCPC ( Dermatology)

Toronto, ON

Melinda Gooderham MD MSc FRCPC Dr. Gooderham is a Dermatologist and Medical Director at the SKiN Centre for Dermatology and an Investigator with Probity Medical Research. She is an Assistant Professor at Queens University and a Consultant Physician at the Peterborough Regional Health Centre. She is a fellow of the Royal College of Physicians and Surgeons of Canada.

Dr. Gooderham has been the principal investigator for over 200 clinical trials and she practices with a focus on inflammatory diseases of the skin. She also contributes to several peer-reviewed dermatology publications as an associate editor, reviewer, and has been an author of 205 articles. She enjoys lecturing to global audiences on new therapies for skin diseases.

About Dr.Jessica Asgarpour, MD, FRCPCDermatologist | Toronto

Dr. Jessica Asgarpour is a Canadian and American board-certified dermatologist. She completed her medical school at the Cumming School of Medicine, in Calgary, Alberta, where she was born and raised. She went on to the University of Alberta for her residency training in dermatology, where she acted as co-chief resident from 2019-2020, and was awarded the Dr. Andrew Lin Dermatology Scholar award. She has also been awarded multiple scholarships to conferences to keep her up-to-date with the ever changing medical literature.

She has published in many peer-reviewed journals, and practices medicine with this same evidence-based approach. She practices medical, surgical and cosmetic dermatology. When she is not practicing dermatology, she enjoys keeping active and loves to run, spin and hike.

📻www.skinandjoints.ca

✉️[email protected]

📻www.skinandjoints.ca

✉️[email protected]

🎙️ Melinda Knows Best at the AAD! 🌟

We’ve got a special LATEBREAKER episode for you, continuing our coverage from the American Academy of Dermatology in San Diego!

👟💡 Pro Tip: Don't miss Dr. Gooderham’s advice on navigating massive convention centers in style and comfort!

We dive into the highly anticipated Delta 3 study, shedding light on long-term safety and efficacy of Delgocitinib cream for Chronic Hand Eczema.

• Subjects who completed the 16-week treatment period in one of the parent trials DELTA 1 and DELTA 2 were treated with twice daily delgocitinib cream as needed to control their chronic hand eczema for 36 weeks.

Practical Tips for Dermatology Practices 🏥💼

• Adapting treatment plans for chronic hand eczema.
• Benefits of as-needed treatment approaches for better patient outcomes.

Dr. Gooderham’s Conference Adventures 🛫👩‍⚕️👨‍⚕️

• Dr. Gooderham also shares her intriguing encounters from Toronto to San Diego, including a surprise meeting with April Armstrong and an old friend from med school. 🛫

Episode Learning Objectives:

1. Understand the primary and secondary endpoints of the Delta 3 study and its implications for treating chronic hand eczema.
2. Learn about the safety profile of Delgocitinib cream and its significance in long-term treatment plans.
3. Gain insights into real-world application of delgocitinib and patient adherence strategies for topical treatments

Lace up those sneakers, grab a protein bar, and join us for a walk through the latest dermatological advancements! 🥾🍫

🎙️ Melinda Knows Best at the AAD – where expert insights meet real-world application (pun intended)📍📍

Episode supported by an IME Grant from LEO Pharma

ABOUT Dr.Melinda Gooderham, MD, FRCPC ( Dermatology)

Dermatologist | Toronto

Toronto, ON

Melinda Gooderham MD MSc FRCPC Dr. Gooderham is a Dermatologist and Medical Director at the SKiN Centre for Dermatology and an Investigator with Probity Medical Research. She is an Assistant Professor at Queens University and a Consultant Physician at the Peterborough Regional Health Centre. She is a fellow of the Royal College of Physicians and Surgeons of Canada.

Dr. Gooderham has been the principal investigator for over 200 clinical trials and she practices with a focus on inflammatory diseases of the skin. She also contributes to several peer-reviewed dermatology publications as an associate editor, reviewer, and has been an author of 205 articles. She enjoys lecturing to global audiences on new therapies for skin diseases.

References

1. Gooderham M. Long-term safety and efficacy of delgocitinib cream for up to 36 weeks in adults with chronic hand eczema: results of the phase 3 open-label extension DELTA 3 trial. Presented at: 2024 American Academy of Dermatology Annual Meeting; March 8-12, 2024; San Diego, CA.

📻www.skinandjoints.ca

✉️[email protected]